Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aurélien Péru"'
Autor:
Christine Lambert-van der Brempt, Jean-Jacques Marcel Lohmann, Twana Saleh, Sébastien L. Degorce, Stephen Green, Rémy Morgentin, Lara Ward, Urs Hancox, Mickaël Maudet, Martina Fitzek, Barlaam Bernard Christophe, Sabina Cosulich, Patrick Ple, Nicolas Warin, Aurélien Péru
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2318-2323
We report the discovery and optimisation of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides, leading to compound 16 as a potent and selective PI3Kβ/δ inhibitor: PI3Kβ cell IC50 0.012 μM (in PTEN nu
Autor:
Sébastien L. Degorce, Patrick Ple, Mickaël Maudet, Jennifer H. Pink, Rowena Callis, Andrew Bailey, Bryan Roberts, Chris De Savi, Richard A. Norman, Rémy Morgentin, Aurélien Péru, Richard Ducray, Scott W. Martin, James S. Scott, Gillian M. Lamont, Philip A. MacFaul
Publikováno v:
Journal of Medicinal Chemistry. 58:3522-3533
A novel estrogen receptor down-regulator, 7-hydroxycoumarin (5, SS5020), has been reported with antitumor effects against chemically induced mammary tumors. Here, we report on our own investigation of 7-hydroxycoumarins as potential selective estroge
Autor:
Stephen Green, Sébastien L. Degorce, Sabina Cosulich, Martina Fitzek, Michel Vautier, Christine Lambert-van der Brempt, Lara Ward, Jean-Jacques Marcel Lohmann, Patrick Ple, Barlaam Bernard Christophe, Marie-Jeanne Pasquet, Rémy Morgentin, Michael A. Walker, Twana Saleh, Nicolas Warin, Aurélien Péru, Urs Hancox, Mickaël Maudet
Publikováno v:
Journal of Medicinal Chemistry. 58:943-962
Several studies have highlighted the dependency of PTEN deficient tumors to PI3Kβ activity and specific inhibition of PI3Kδ has been shown activity against human B-cell cancers. We describe the discovery and optimization of a series of 8-(1-anilino
Autor:
Patrick Ple, Antoine Le Griffon, Janet Hawkins, Barlaam Bernard Christophe, Rémy Morgentin, Lorraine A. Hassall, Kevin Michael Foote, Clifford David Jones, Aurélien Péru
Publikováno v:
Synthetic Communications. 42:8-24
We have developed two different approaches in parallel to rapidly access 2,4-bis aminoaryl pyridine compounds from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then
Autor:
Franck Lach, Aurélien Péru
Publikováno v:
Tetrahedron Letters. 53:691-693
Herein, we report two synthetically useful and high yielding routes to so far unknown branched γ,γ′- and δ,δ′-difluoroalkylamines that can be of interest as building-blocks for medicinal chemistry programs.
Autor:
Lara Ward, Sébastien L. Degorce, Michel Vautier, Nicolas Warin, Michael A. Walker, Stephen Green, Twana Saleh, Martina Fitzek, C. Lambert-van der Brempt, Aurélien Péru, Mickaël Maudet, J.-J. M. Lohmann, Barlaam Bernard Christophe, Patrick Ple, Urs Hancox, Rémy Morgentin, Sabina Cosulich, M.J. Pasquest
Publikováno v:
European Journal of Cancer. 50:90-91
Autor:
Aurélien Péru, Patrick Ple, Jennifer H. Pink, Bryan Roberts, Richard A. Norman, Rowena Callis, Andrew Bailey, James S. Scott, Richard Ducray, Mickaël Maudet, Rémy Morgentin, Chris De Savi, Philip A. MacFaul, Sébastien L. Degorce, Scott W. Martin, Gillian M. Lamont
Publikováno v:
Journal of Medicinal Chemistry. 59:3576-3576
Autor:
Rémy Morgentin, Clifford David Jones, Aurélien Péru, Lorraine A. Hassall, Janet Hawkins, Barlaam Bernard Christophe, Patrick Ple, Kevin Michael Foote, Antoine Le Griffon
Publikováno v:
ChemInform. 43
Two different approaches to synthesize 2,4-bis-aminoaryl pyridine derivatives are introduced.