Výsledky vyhledávání - "Aurélie Rondon"

Radioimmunotherapy in Oncology: Overview of the Last Decade Clinical Trials

Autor: Aurélie Rondon, Françoise Degoul, Jacques Rouanet

Publikováno v: Cancers
Cancers, Vol 13, Iss 5570, p 5570 (2021)

Simple Summary Monoclonal antibody-bearing radionuclides have been under clinical investigation over the last two decades for their use in theranostic (diagnostic and therapeutic) applications in cancer. However, despite the numerous trials that have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45880ae643710987c7ac3f46ac7c04b6
https://pubmed.ncbi.nlm.nih.gov/34771732

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Biodistribution and elimination pathways of PEGylated recombinant human deoxyribonuclease I after pulmonary delivery in mice

Autor: Aurélie Rondon, Sohaib Mahri, Rita Vanbever, Cynthia Bosquillon, Tobias Wilms

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society, Vol. 329, p. 1054-1065 (2021)

Conjugation of recombinant human deoxyribonuclease I (rhDNase) to polyethylene glycol (PEG) of 20 to 40 kDa was previously shown to prolong the residence time of rhDNase in the lungs of mice after pulmonary delivery while preserving its full enzymati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b3a8553b10dbfdd30af28b73dd582f
https://hdl.handle.net/2078.1/239507

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Protein Engineering Strategies for Improved Pharmacokinetics

Autor: Mireille Dumoulin, Aurélie Rondon, Sohaib Mahri, Rita Vanbever, Francisco Morales-Yanez

Publikováno v: Advanced Functional Materials, p. 2101633 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e521d595ea230c562bf2edf5532ae9
https://hdl.handle.net/2078.1/248311

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Optimization of IEDDA bioorthogonal system: Efficient process to improve trans-cyclooctene/tetrazine interaction

Autor: Jean-Michel Chezal, Ludivine Taiariol, Jean-Baptiste Béquignat, Elisabeth Miot-Noirault, Mercedes Quintana, Isabelle Navarro-Teulon, Claude Boucheix, Françoise Degoul, Damien Canitrot, Aurélie Rondon, Nancy Ty, Emmanuel Moreau

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, 203, pp.112574. ⟨10.1016/j.ejmech.2020.112574⟩
European Journal of Medicinal Chemistry, 2020, 203, pp.112574. ⟨10.1016/j.ejmech.2020.112574⟩

International audience; The antibody pretargeting approach for radioimmunotherapy (RIT) using inverse electron demand Diels-Alder cycloaddition (IEDDA) constitutes an emerging theranostic approach for solid cancers. However, IEDDA pretargeting has no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f203859313cbef54fc2fc0f6e8bbae83
https://pubmed.ncbi.nlm.nih.gov/32683167

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Antibody Pretargeting Based on Bioorthogonal Click Chemistry for Cancer Imaging and Targeted Radionuclide Therapy

Autor: Aurélie Rondon, Françoise Degoul

Publikováno v: Bioconjugate Chemistry
Bioconjugate Chemistry, American Chemical Society, 2019, 31 (2), pp.159-173. ⟨10.1021/acs.bioconjchem.9b00761⟩

International audience; Bioorthogonal click chemistry-employing antibody-conjugated trans-cyclooctenes (TCO) and tetrazine (Tz)-based radioligands able to covalently bind in vivo-appeared recently as a potential alternative to circumvent the hematoto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5703ac6c6202d79607734d85227e82
https://hal.archives-ouvertes.fr/hal-02887982

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Pretargeted radioimmunotherapy and SPECT imaging of peritoneal carcinomatosis using bioorthogonal click chemistry: probe selection and first proof-of-concept

Autor: Emmanuel Moreau, Jean-Pierre Pouget, Lydia Maigne, Sébastien Schmitt, Elisabeth Miot-Noirault, Mercedes Quintana, Jean-Michel Chezal, Isabelle Navarro-Teulon, Aurélie Rondon, Arnaud Briat, Françoise Degoul, Brian M. Zeglis, Nancy Ty, Rosemery Membreno

Publikováno v: Theranostics
Theranostics, Ivyspring International Publisher, 2019, 9 (22), pp.6706-6718. ⟨10.7150/thno.35461⟩
Theranostics, 2019, 9 (22), pp.6706-6718. ⟨10.7150/thno.35461⟩

International audience; Rationale: Pretargeted radioimmunotherapy (PRIT) based upon bioorthogonal click chemistry has been investigated for the first time in the context of peritoneal carcinomatosis using a CEA-targeting 35A7 mAb bearing trans-cycloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f83622f10f79e0d9402d0bb27b4ddf
https://hal.archives-ouvertes.fr/hal-02305887/file/v09p6706.pdf

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Antibody PEGylation in bioorthogonal pretargeting with trans-cyclooctene/tetrazine cycloaddition: in vitro and in vivo evaluation in colorectal cancer models

Autor: Tiffany Witkowski, Jean-Baptiste Béquignat, Emmanuel Moreau, Jean-Pierre Pouget, Mercedes Quintana, Aurélie Rondon, Claude Boucheix, Françoise Degoul, Nancy Ty, Arnaud Briat, Bernadette Bouchon, Isabelle Navarro-Teulon, Jean-Michel Chezal, Elisabeth Miot-Noirault

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-15051-y⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Nature Publishing Group, 2017, 7 (1), 〈10.1038/s41598-017-15051-y〉
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-15051-y⟩

Bioorthogonal chemistry represents a challenging approach in pretargeted radioimmunotherapy (PRIT). We focus here on mAb modifications by grafting an increase amount of trans-cyclooctene (TCO) derivatives (0 to 30 equivalents with respect to mAb) bea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d31f2a734f6aee369c50c6a56b748a
https://hal.archives-ouvertes.fr/hal-01646770

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