The CD47/TSP-1 axis: a promising avenue for ovarian cancer treatment and biomarker research

Autor: Aurélie Moniot, Christophe Schneider, Laure Chardin, Elisa Yaniz-Galende, Catherine Genestie, Marion Etiennot, Aubéri Henry, Coralie Drelon, Audrey Le Formal, Benoit Langlois, Laurence Venat, Christophe Louvet, Laure Favier, Alain Lortholary, Dominique Berton-Rigaud, Nadine Dohollou, Christophe Desauw, Michel Fabbro, Emmanuelle Malaurie, Coraline Dubot, Jean Emmanuel Kurtz, Nathalie Bonichon Lamichhane, Éric Pujade-Lauraine, Albin Jeanne, Alexandra Leary, Stéphane Dedieu

Publikováno v: Molecular Cancer, Vol 23, Iss 1, Pp 1-17 (2024)

Abstract Background Ovarian cancer (OC) remains one of the most challenging and deadly malignancies facing women today. While PARP inhibitors (PARPis) have transformed the treatment landscape for women with advanced OC, many patients will relapse and

Externí odkaz: https://doaj.org/article/dd3b485e8ca3415e9aedea04cb9e8214

Osteoinductive Material to Fine-Tune Paracrine Crosstalk of Mesenchymal Stem Cells With Endothelial Cells and Osteoblasts

Autor: Hassan Rammal, Laura Entz, Marie Dubus, Aurélie Moniot, Nicolae B. Bercu, Johan Sergheraert, Sophie C. Gangloff, Cédric Mauprivez, Halima Kerdjoudj

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)

While stem cell/biomaterial studies provide solid evidences that biomaterial intrinsic cues deeply affect cell fate, current strategies tend to neglect their effects on mesenchymal stem cells (MSCs) secretory activities and resulting cell-crosstalks.

Externí odkaz: https://doaj.org/article/df4f48d6f73345d591c94f40945adb27

Inhibition of Recruitment and Activation of Neutrophils by Pyridazinone-Scaffold-Based Compounds

Autor: Aurélie, Moniot, Julien, Braux, Renaud, Siboni, Christine, Guillaume, Sandra, Audonnet, Ingrid, Allart-Simon, Janos, Sapi, Rabindra, Tirouvanziam, Stéphane, Gérard, Sophie C, Gangloff, Frédéric, Velard

Publikováno v: International journal of molecular sciences. 23(13)

In inflammatory diseases, polymorphonuclear neutrophils (PMNs) are known to produce elevated levels of pro-inflammatory cytokines and proteases. To limit ensuing exacerbated cell responses and tissue damage, novel therapeutic agents are sought. 4aa a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7bc825e6a9b950d012d7fdb1627ea4b2
https://pubmed.ncbi.nlm.nih.gov/35806233

Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors

Autor: Frédéric Velard, Nicolo Bisi, Janos Sapi, Sandra Audonnet, Aurélie Moniot, Stéphane Gérard, Marie Laronze-Cochard, Eric Hénon, Ingrid Allart-Simon, Miguel Ponce-Vargas

Publikováno v: RSC Medicinal Chemistry
RSC Medicinal Chemistry, Royal Society of Chemistry, 2021, 12, pp.584-592. ⟨10.1039/d0md00423e⟩
RSC Med Chem

International audience; Cyclic nucleotide phosphodiesterase type 4 (PDE4), which controls the intracellular level of cyclic adenosine monophosphate (cAMP), has aroused scientific attention as a suitable target for antiinflammatory therapy of respirat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713631ad5f71ac378605bffc82252434
https://hal.archives-ouvertes.fr/hal-03352041

Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents

Autor: Laurette Malleret, Janos Sapi, Chantal Barberot, Ingrid Allart-Simon, Jean-Philippe Bouillon, Aurélie Moniot, Frédéric Velard, Marie Laronze-Cochard, Eric Hénon, Maurice Médebielle, Stéphane Gérard, Abderrazzaq Bentaher, Tatiana Yegorova

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 146, pp.139-146. ⟨10.1016/j.ejmech.2018.01.035⟩
European Journal of Medicinal Chemistry, 2018, 146, pp.139-146. ⟨10.1016/j.ejmech.2018.01.035⟩

International audience; Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63c04fdaba7f3c4e667ea748cea6720
https://hal-normandie-univ.archives-ouvertes.fr/hal-02024470