Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Aurélie Mallinger"'
Autor:
Paul A Clarke, Maria-Jesus Ortiz-Ruiz, Robert TePoele, Olajumoke Adeniji-Popoola, Gary Box, Will Court, Stephanie Czasch, Samer El Bawab, Christina Esdar, Ken Ewan, Sharon Gowan, Alexis De Haven Brandon, Phillip Hewitt, Stephen M Hobbs, Wolfgang Kaufmann, Aurélie Mallinger, Florence Raynaud, Toby Roe, Felix Rohdich, Kai Schiemann, Stephanie Simon, Richard Schneider, Melanie Valenti, Stefan Weigt, Julian Blagg, Andree Blaukat, Trevor C Dale, Suzanne A Eccles, Stefan Hecht, Klaus Urbahns, Paul Workman, Dirk Wienke
Publikováno v:
eLife, Vol 5 (2016)
Mediator-associated kinases CDK8/19 are context-dependent drivers or suppressors of tumorigenesis. Their inhibition is predicted to have pleiotropic effects, but it is unclear whether this will impact on the clinical utility of CDK8/19 inhibitors. We
Externí odkaz:
https://doaj.org/article/a201fbf6b4ca430996a70dd003f4f498
Autor:
Christoph Steeneck, Olaf Kinzel, Simon Anderhub, Aurélie Mallinger, Marta Czekańska, Sheena Pinto, Barbara Morschhaeuser, Christina Sonnek, Martin Hornberger, Thomas J. Hoffmann, Michael Albers, Yansong Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 33:127738
Through structural modification of an oxalamide derived chemotype, a novel class of highly potent, orally bioavailable IDO1-specific inhibitors was identified. Representative compound 18 inhibited human IDO1 with IC50 values of 3.9 nM and 52 nM in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373dcfd00c06df0df2fd5d34994a7c3e
https://doi.org/10.1016/j.bmcl.2020.127738
https://doi.org/10.1016/j.bmcl.2020.127738
Autor:
Djordje Musil, Suzanne A. Eccles, Daniel Schwarz, Klaus Urbahns, Trevor Clive Dale, Paul A. Clarke, Christina Esdar, Paul Czodrowski, Maria-Jesus Ortiz-Ruiz, Oliver Pöschke, Florence I. Raynaud, Aurélie Mallinger, Dirk Wienke, Kai Schiemann, Richard Schneider, Felix Rohdich, Michael Busch, Julian Blagg
Publikováno v:
Journal of Medicinal Chemistry. 59:9337-9349
The mediator complex-associated cyclin dependent kinase CDK8 regulates β-catenin-dependent transcription following activation of WNT signaling. Multiple lines of evidence suggest CDK8 may act as an oncogene in the development of colorectal cancer. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ecdf42911d63ceaf78c9765d5396808
https://doi.org/10.1021/acs.jmedchem.6b00597
https://doi.org/10.1021/acs.jmedchem.6b00597
Autor:
Kai Schiemann, Djordje Musil, Oliver Poeschke, Klaus Urbahns, Suzanne A. Eccles, Florence I. Raynaud, Felix Rohdich, Daniel Schwarz, Christina Esdar, Aurélie Mallinger, Julian Blagg, Michael Busch, Dirk Wienke, Paul Czodrowski, Richard Schneider
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1443-1451
Here we describe the discovery and optimization of 3-benzylindazoles as potent and selective inhibitors of CDK8, also modulating CDK19, discovered from a high-throughput screening (HTS) campaign sampling the Merck compound collection. The primary hit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2d87e947ec772d87d3085bfec8d968
https://doi.org/10.1016/j.bmcl.2016.01.062
https://doi.org/10.1016/j.bmcl.2016.01.062
Autor:
Alexis De Haven Brandon, Paul Workman, Aurélie Mallinger, Elizabeth Fraser, Mark Stubbs, Paul Czodrowski, Andree Blaukat, Richard Schneider, Julian Blagg, Djordje Musil, Melanie Valenti, Daniel Schwarz, Rahul S. Samant, Klaus Schneider, Kai Schiemann, Sharon Gowan, Christina Esdar, Florence I. Raynaud, Suzanne A. Eccles, Robert TePoele, Dennis Waalboer, Gary Box, Dirk Wienke, Oliver Poeschke, Paul A. Clarke, Maria-Jesus Ortiz-Ruiz, Kenneth Burnside Ramsay Ewan, Trevor Clive Dale, Felix Rohdich, Olajumoke Adeniji-Popoola, Will Court
Publikováno v:
Nature chemical biology
There is unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545, a small-molecule inhibitor of the WNT pathway discovered through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5843c8e5265bc355469118273fb45d0b
https://doi.org/10.1038/nchembio.1952
https://doi.org/10.1038/nchembio.1952
Over the past two decades there has been a great deal of interest in the development of inhibitors of the Cyclin-dependent kinases (CDKs). This attention initially stemmed from observations that different CDK isoforms have key roles in cancer cell pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a01ee9f56d5c3bbe332e0cbdd29643
https://europepmc.org/articles/PMC6141011/
https://europepmc.org/articles/PMC6141011/
Autor:
Toby Roe, Will Court, Felix Rohdich, Julian Blagg, Wolfgang Kaufmann, Stefan Hecht, Richard Schneider, Stephen M. Hobbs, Christina Esdar, Alexis De Haven Brandon, Samer El Bawab, Phllip Hewitt, Suzanne A. Eccles, Kai Schiemann, Trevor Clive Dale, Paul Workman, Aurélie Mallinger, Stefan Weigt, Klaus Urbahns, Olajumoke Adeniji-Popoola, Andree Blaukat, Stephanie Simon, Robert TePoele, Melanie Valenti, Sharon Gowan, Stefanie Czasch, Paul A. Clarke, Gary Box, Dirk Wienke, Kenneth Burnside Ramsay Ewan, Maria-Jesus Ortiz-Ruiz, Florence I. Raynaud
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Mediator-associated kinases CDK8/19 are context-dependent drivers or suppressors of tumorigenesis. Their inhibition is predicted to have pleiotropic effects, but it is unclear whether this will impact on the clinical utility of CDK8/19 inhibitors. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320a3dd4067dcc727c7a6157a8004c42
http://europepmc.org/articles/PMC5224920
http://europepmc.org/articles/PMC5224920
Autor:
Aurélie Mallinger, Anette Funk, Nina Hambruch, Yansong Wang, Michael Albers, Olaf Kinzel, Christian Gege, Annika Bittman-Waetzig, Johannes Fabian, Barbara Herkert, Floriane Braun, Tilly Fleckenstein, Gero Fink, Claus Kremoser
Publikováno v:
Cancer Research. 79:3588-3588
A key metabolic alteration in tumor cells is an elevated glycolysis rate, resulting in the production of increased amounts of protons and lactate leading to lactic acidosis within the tumor microenvironment. The tumor-promoting effects of lactic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90641642e336b17a41fd2450b09e119f
https://doi.org/10.1158/1538-7445.am2019-3588
https://doi.org/10.1158/1538-7445.am2019-3588
Autor:
Andree Blaukat, Sharon Gowan, Richard Schneider, Suzanne A. Eccles, Gary Box, Dirk Wienke, Paul Workman, Robert TePoele, Stefan Hecht, Kai Schiemann, Trevor Clive Dale, Paul A. Clarke, Melanie Valenti, Toby Roe, Felix Rohdich, Wolfgang Kaufmann, Stephanie Czasch, Maria-Jesus Ortiz-Ruiz, Christina Esdar, Stefan Weigt, Kenneth Burnside Ramsay Ewan, Aurélie Mallinger, Alexis De Haven Brandon, Phillip Hewitt, Olajumoke Adeniji-Popoola, Will Court, Florence I. Raynaud, Stephen M. Hobbs, Stephanie Simon, Julian Blagg, Samer El Bawab, Klaus Urbahns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fdc132145578e222df38589324159b5
https://doi.org/10.7554/elife.20722.047
https://doi.org/10.7554/elife.20722.047
Autor:
Alexandre Korovitch, Thierry Le Gall, Vincent Souchon, Jean-Baptiste Mulon, Brice Nadal, Claude Lion, Jean-Michel El Hage Chahine, Isabelle Leray, Bernard Valeur, Aurélie Mallinger, Nguyêt-Thanh Ha-Duong
Publikováno v:
The Journal of Physical Chemistry B. 114:12655-12665
Norbadione A (NbA) is a mushroom pigment, which is assumed to be involved in (137)Cs accumulation all over Europe during the Chernobyl nuclear accident. NbA bears seven acid-base functional groups, among which are two enolic and two carboxylic acid m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b7e2c803a88c170d644b36f90d5497
https://doi.org/10.1021/jp1060232
https://doi.org/10.1021/jp1060232