Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Aurélie Le Lay"'
Autor:
Aurélie Le Lay, Erwann Philippe, Fanny Roth, Ana Rodriguez Sanchez-Archidona, Florence Mehl, Jessica Denom, Rashmi Prasad, Olof Asplund, Ola Hansson, Mark Ibberson, Fabrizio Andreelli, Lyse Santoro, Paul Amouyal, Gilles Amouyal, Christian Brechot, Laure Jamot, Céline Cruciani-Guglielmacci, Christophe Magnan
Publikováno v:
Heliyon, Vol 8, Iss 7, Pp e09944- (2022)
The aim of our study was to test the hypothesis that administration of Regenerating islet-derived protein 3α (Reg3α), a protein described as having protective effects against oxidative stress and anti-inflammatory activity, could participate in the
Externí odkaz:
https://doaj.org/article/39cc50e19eae451892b45ead46bd57b6
Autor:
Francois Brial, Fawaz Alzaid, Kazuhiro Sonomura, Yoichiro Kamatani, Kelly Meneyrol, Aurélie Le Lay, Noémie Péan, Lyamine Hedjazi, Taka-Aki Sato, Nicolas Venteclef, Christophe Magnan, Mark Lathrop, Marc-Emmanuel Dumas, Fumihiko Matsuda, Pierre Zalloua, Dominique Gauguier
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2306-2320.e5 (2020)
Summary: Exposure to natural metabolites contributes to the risk of cardiometabolic diseases (CMDs). Through metabolome profiling, we identify the inverse correlation between serum concentrations of 4-cresol and type 2 diabetes. The chronic administr
Externí odkaz:
https://doaj.org/article/32e9beb218a54a328a3b0c228d5df1d6
Autor:
Georg W. Otto, Pamela J. Kaisaki, Francois Brial, Aurélie Le Lay, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
To define renal molecular mechanisms that are affected by permanent hyperglycaemia and might promote phenotypes relevant to diabetic nephropathy, we carried out linkage analysis of genome-wide gene transcription in the kidneys of F2 offspring from th
Externí odkaz:
https://doaj.org/article/d979937a0bc24797ae8857c1bcbbda14
Autor:
Petros Andrikopoulos, Fatima Djouadi, Lesley Hoyles, Trine Nielsen, Matej Orešič, Karine Clément, Nicolas Pons, Andrea Rodriguez-Martinez, Sofia K. Forslund, Gwen Falony, Francois Brial, Stanislav Dusko Ehrlich, Tuulia Hyötyläinen, Dominique Gauguier, Peer Bork, Marc-Emmanuel Dumas, Michael Olanipekun, Ana Luisa Neves, Jeroen Raes, Julien Chilloux, Jeremy K. Nicholson, Sara Vieira-Silva, Torben Hansen, Emmanuelle Le-chatelier, Aurélie Le Lay, Oluf Pedersen, Ghiwa Ishac Mouawad
Publikováno v:
Gut
Gut, 2021, 70 (11), pp.2105-2114. ⟨10.1136/gutjnl-2020-323314⟩
Gut, BMJ Publishing Group, 2021, 70 (11), pp.2105-2114. ⟨10.1136/gutjnl-2020-323314⟩
Brial, F, Chilloux, J, Nielsen, T, Vieira-Silva, S, Falony, G, Andrikopoulos, P, Olanipekun, M, Hoyles, L, Djouadi, F, Neves, A L, Rodriguez-Martinez, A, Mouawad, G I, Pons, N, Forslund, S, Le-chatelier, E, Le Lay, A, Nicholson, J, Hansen, T, Hyotylainen, T, Clement, K, Oresic, M, Bork, P, Ehrlich, S D, Raes, J, Pedersen, O B, Gauguier, D & Dumas, M-E 2021, ' Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health ', Gut, vol. 70, no. 11, pp. 2105-2114 . https://doi.org/10.1136/gutjnl-2020-323314
Gut, 2021, 70 (11), pp.2105-2114. ⟨10.1136/gutjnl-2020-323314⟩
Gut, BMJ Publishing Group, 2021, 70 (11), pp.2105-2114. ⟨10.1136/gutjnl-2020-323314⟩
Brial, F, Chilloux, J, Nielsen, T, Vieira-Silva, S, Falony, G, Andrikopoulos, P, Olanipekun, M, Hoyles, L, Djouadi, F, Neves, A L, Rodriguez-Martinez, A, Mouawad, G I, Pons, N, Forslund, S, Le-chatelier, E, Le Lay, A, Nicholson, J, Hansen, T, Hyotylainen, T, Clement, K, Oresic, M, Bork, P, Ehrlich, S D, Raes, J, Pedersen, O B, Gauguier, D & Dumas, M-E 2021, ' Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health ', Gut, vol. 70, no. 11, pp. 2105-2114 . https://doi.org/10.1136/gutjnl-2020-323314
ObjectiveGut microbial products are involved in regulation of host metabolism. In human and experimental studies, we explored the potential role of hippurate, a hepatic phase 2 conjugation product of microbial benzoate, as a marker and mediator of me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d9d81ce9f99ebb92c836853b611c64
https://cnrs.hal.science/hal-03451210
https://cnrs.hal.science/hal-03451210
Autor:
Jessica Wasserscheid, Marc-Emmanuel Dumas, Antonis Myridakis, Lyamine Hedjazi, Francois Brial, Noémie Péan, Dominique Gauguier, Ken Dewar, Mylène Vincent, Christophe Magnan, Aurélie Le Lay, Mark Lathrop, Elin Grundberg, Claude Rouch
Publikováno v:
Diabetologia
Diabetologia, Springer Verlag, 2020, 63 (6), pp.1223-1235. ⟨10.1007/s00125-020-05122-7⟩
Diabetologia, Springer Verlag, 2020, 63 (6), pp.1223-1235. ⟨10.1007/s00125-020-05122-7⟩
Aims/hypothesis Drug and surgical-based therapies in type 2 diabetes are associated with altered gut microbiota architecture. Here we investigated the role of the gut microbiome in improved glucose homeostasis following bariatric surgery. Methods We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e593ba8c29f8acd0b9732cab5870f0
https://hal-cnrs.archives-ouvertes.fr/hal-03089346
https://hal-cnrs.archives-ouvertes.fr/hal-03089346
Autor:
Ivo Gut, Nicolas Venteclef, Georg W. Otto, Fawaz Alzaid, Tsz M. Tsang, Christopher P. Day, Mark Lathrop, Marc-Emmanuel Dumas, Jeremy K. Nicholson, Aurélie Le Lay, Jean-Baptiste Cazier, Lyamine Hedjazi, Jane F. Fearnside, Francois Brial, Dominique Gauguier, Alastair D. Burt, Steven P. Wilder
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9, pp.3656. ⟨10.1038/s41598-019-40153-0⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9, pp.3656. ⟨10.1038/s41598-019-40153-0⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Non-alcoholic fatty liver disease (NAFLD) is often associated with obesity and type 2 diabetes. To disentangle etiological relationships between these conditions and identify genetically-determined metabolites involved in NAFLD processes, we mapped 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae1a745d29524ba1e96ca10fbaa0f6b
Autor:
Richard Mott, Georg W. Otto, Aurélie Le Lay, Dominique Gauguier, Francois Brial, Jean-Baptiste Cazier, Pamela J. Kaisaki
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
To define renal molecular mechanisms that are affected by permanent hyperglycaemia and might promote phenotypes relevant to diabetic nephropathy, we carried out linkage analysis of genome-wide gene transcription in the kidneys of F2 offspring from th
Autor:
Alexandre Colleu, Essa Hariri, David Touboul, Pierre Zalloua, Jeremy K. Nicholson, Lyamine Hedjazi, Dominique Gauguier, Francois Brial, Hanane Kadar, Aurélie Le Lay, Mark Lathrop, Marc-Emmanuel Dumas, Justine Dubus, Layal Abi Farraj, Fumihiko Matsuda
Publikováno v:
Lipids in Health and Disease
Lipids in Health and Disease, 2019, 18 (1), pp.38. ⟨10.1186/s12944-018-0948-5⟩
Lipids in Health and Disease, BioMed Central, 2019, 18 (1), pp.38. ⟨10.1186/s12944-018-0948-5⟩
Lipids in Health and Disease, BioMed Central, 2019, 18 (1), ⟨10.1186/s12944-018-0948-5⟩
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-10 (2019)
Lipids in Health and Disease, 2019, 18 (1), pp.38. ⟨10.1186/s12944-018-0948-5⟩
Lipids in Health and Disease, BioMed Central, 2019, 18 (1), pp.38. ⟨10.1186/s12944-018-0948-5⟩
Lipids in Health and Disease, BioMed Central, 2019, 18 (1), ⟨10.1186/s12944-018-0948-5⟩
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-10 (2019)
Background Lipoproteins are major players in the development and progression of atherosclerotic plaques leading to coronary stenosis and myocardial infarction. Epidemiological, genetic and experimental observations have implicated the association of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c9f09da414c52e790fd104c1005fbd
http://hdl.handle.net/10044/1/68186
http://hdl.handle.net/10044/1/68186
Autor:
Pierre Zalloua, Jeremy K. Nicholson, Fumihiko Matsuda, Christophe Magnan, Kelly Meneyrol, Kazuhiro Sonomura, Dominique Gauguier, Aurélie Le Lay, Lyamine Hedjazi, Fawaz Alzaid, Nicolas Venteclef, Noémie Péan, Andrea Rodriguez Martinez, Taka-Aki Sato, Ana Luisa Neves, Marc-Emmanuel Dumas, Francois Brial, Mark Lathrop, Julien Chilloux
SUMMARYGut microbiota changes are associated with increased risk of Type 2 diabetes (T2D) and obesity. Through serum metabolome profiling in patients with cardiometabolic disease (CMD) we identified significant inverse correlation between the microbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2265e6d8b4b9213d7822afb175ea8d7f
Autor:
Pierre Zalloua, Hanane Kadar, Essa Hariri, Layal Abi Farraj, Francois Brial, Lyamine Hedjazi, Aurelie Le Lay, Alexandre Colleu, Justine Dubus, David Touboul, Fumihiko Matsuda, Mark Lathrop, Jeremy K. Nicholson, Marc-Emmanuel Dumas, Dominique Gauguier
Publikováno v:
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-10 (2019)
Abstract Background Lipoproteins are major players in the development and progression of atherosclerotic plaques leading to coronary stenosis and myocardial infarction. Epidemiological, genetic and experimental observations have implicated the associ
Externí odkaz:
https://doaj.org/article/0f841e838d45496fa533e172b6df96fa