Discovery of potent 1,1-diarylthiogalactoside glycomimetic inhibitors of Pseudomonas aeruginosa LecA with antibiofilm properties

Autor: Alexandre Bruneau, Emilie Gillon, Aurélie Furiga, Etienne Brachet, Mouad Alami, Christine Roques, Annabelle Varrot, Anne Imberty, Samir Messaoudi

Publikováno v: European Journal of Medicinal Chemistry. 247:115025

In this work, β-thiogalactoside mimetics bearing 1,1-diarylmethylene or benzophenone aglycons have been prepared and assayed for their affinity towards LecA, a lectin and virulence factor from Pseudomonas aeruginosa involved in bacterial adhesion an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f569bd072c97f786ce50fd9d195d9dc2
https://doi.org/10.1016/j.ejmech.2022.115025

Synthesis,antimicrobial activity and physico-chemical properties of some n-alkyldimethylbenzylammonium halides

Autor: Salomé El Hage, Christine Roques, Jean-Luc Stigliani, Geneviève Baziard, Barbora Lajoie, Aurélie Furiga-Chusseau

Publikováno v: Journal of Applied Biomedicine
Journal of Applied Biomedicine, University of South Bohemia in České Budějovice, 2014, 12 (4), pp.245-253. ⟨10.1016/j.jab.2014.02.002⟩
Journal of Applied Biomedicine, 2014, 12 (4), pp.245-253. ⟨10.1016/j.jab.2014.02.002⟩

International audience; Quaternary ammonium salts (chloride, bromide and iodide; QUATs) with n-alkyl chain lengths between C8 and C18 have been synthesized under optimized experimental conditions. These compounds were tested in vitro for antimicrobia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e326c47b3f312b837f246485837c79c
https://oatao.univ-toulouse.fr/20234/