Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Aurélie Fossey-Jouenne"'
1
Akademický článek
A refined picture of the native amine dehydrogenase family revealed by extensive biodiversity screening
Autor: Eddy Elisée, Laurine Ducrot, Raphaël Méheust, Karine Bastard, Aurélie Fossey-Jouenne, Gideon Grogan, Eric Pelletier, Jean-Louis Petit, Mark Stam, Véronique de Berardinis, Anne Zaparucha, David Vallenet, Carine Vergne-Vaxelaire
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Native amine dehydrogenases offer sustainable access to chiral amines, so the search for scaffolds capable of converting more diverse carbonyl compounds is required to reach the full potential of this alternative to conventional synthetic re
Externí odkaz: https://doaj.org/article/19dd54a88db747b3aaeff48cb3524f74
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2
Akademický článek
Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering
Autor: Nikolas Capra, Chloé Lelièvre, Océane Touré, Aurélie Fossey-Jouenne, Carine Vergne-Vaxelaire, Dick B. Janssen, Andy-Mark W. H. Thunnissen, Anne Zaparucha
Publikováno v: Frontiers in Catalysis, Vol 4 (2024)
The CoA ligase from Metallosphaera sedula (MsACL) can be used for the chemoenzymatic synthesis of amides from carboxylic acids. In this CoA-independent conversion, the enzyme catalyzes the adenylation of a carboxylic acid with the help of ATP, follow
Externí odkaz: https://doaj.org/article/e79be1107d974a38a3146cf5d3218eee
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3
Akademický článek
Native amine dehydrogenases can catalyze the direct reduction of carbonyl compounds to alcohols in the absence of ammonia
Autor: Aurélie Fossey-Jouenne, Laurine Ducrot, Ewald P. J. Jongkind, Eddy Elisée, Anne Zaparucha, Gideon Grogan, Caroline E. Paul, Carine Vergne-Vaxelaire
Publikováno v: Frontiers in Catalysis, Vol 3 (2023)
Native amine dehydrogenases (nat-AmDHs) catalyze the (S)-stereoselective reductive amination of various ketones and aldehydes in the presence of high concentrations of ammonia. Based on the structure of CfusAmDH from Cystobacter fuscus complexed with
Externí odkaz: https://doaj.org/article/c32f5be7224942469cfcd8089113a86c
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4
Akademický článek
XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii
Autor: Jérémy Domergue, Diane Erdmann, Aurélie Fossey-Jouenne, Jean-Louis Petit, Adrien Debard, Véronique de Berardinis, Carine Vergne-Vaxelaire, Anne Zaparucha
Publikováno v: AMB Express, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Flavin-dependent halogenases (FHals) catalyse the halogenation of electron-rich substrates, mainly aromatics. Halogenated compounds have many applications, as pharmaceutical, agrochemicals or as starting materials for the synthesis of comple
Externí odkaz: https://doaj.org/article/6456068c0d5a413fa45760cd3270acca
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6
Expanding the Substrate Scope of Native Amine Dehydrogenases through In Silico Structural Exploration and Targeted Protein Engineering
Autor: Laurine Ducrot, Megan Bennett, Gwenaëlle André‐Leroux, Eddy Elisée, Sacha Marynberg, Aurélie Fossey‐Jouenne, Anne Zaparucha, Gideon Grogan, Carine Vergne‐Vaxelaire
Publikováno v: ChemCatChem
ChemCatChem, 2022, 2022, pp.e202200880. ⟨10.1002/cctc.202200880⟩
International audience; Native Amine Dehydrogenases (nat-AmDHs) are NAD(P)H-enzymes performing reductive amination, mainly active towards small aliphatic aldehydes and cyclic ketones, due to active site volumes limited by the presence of several bulk
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89f08329eeff2420e990ee5604baee9
https://doi.org/10.1002/cctc.202200880
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7
Synthesis of Chiral Amines via a Bi-Enzymatic Cascade Using an Ene-Reductase and Amine Dehydrogenase
Autor: Ewald P. J. Jongkind, Aurélie Fossey‐Jouenne, Ombeline Mayol, Anne Zaparucha, Carine Vergne‐Vaxelaire, Caroline E. Paul
Publikováno v: ChemCatChem, 14(2)
Access to chiral amines with more than one stereocentre remains challenging, although an increasing number of methods are emerging. Here we developed a proof-of-concept bi-enzymatic cascade, consisting of an ene reductase and amine dehydrogenase (AmD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c6ac9f31488433207df4d9ee346d4d
http://resolver.tudelft.nl/uuid:cc2e0dce-1518-4d6b-aed1-107e6d48e9f9
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8
XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii
Autor: Carine Vergne-Vaxelaire, Anne Zaparucha, Jean-Louis Petit, Véronique de Berardinis, Aurélie Fossey-Jouenne, Adrien Debard, Diane Erdmann, Jérémy Domergue
Publikováno v: AMB Express
AMB Express, 2019, 9 (1), pp.175. ⟨10.1186/s13568-019-0898-y⟩
AMB Express, Springer Nature, 2019, 9 (1), pp.175. ⟨10.1186/s13568-019-0898-y⟩
AMB Express, Vol 9, Iss 1, Pp 1-11 (2019)
Flavin-dependent halogenases (FHals) catalyse the halogenation of electron-rich substrates, mainly aromatics. Halogenated compounds have many applications, as pharmaceutical, agrochemicals or as starting materials for the synthesis of complex molecul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6688ca807a2fbd3e4c82d689fc7181f7
https://doi.org/10.1186/s13568-019-0898-y
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9
Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Autor: Carine Vergne-Vaxelaire, Anne Zaparucha, Aurélie Fossey-Jouenne
Amino alcohols are versatile compounds with a wide range of applications. For instance, they have been used as chiral scaffolds in organic synthesis. Their synthesis by conventional organic chemistry often requires tedious multi-step synthesis proces
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fed637f65182ab28edffd783e3ead3c
https://europepmc.org/articles/PMC5931277/
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10
Characterization of a thermotolerant ROK-type mannofructokinase from Streptococcus mitis: application to the synthesis of phosphorylated sugars
Autor: Véronique de Berardinis, Ekaterina Darii, Aurélie Fossey-Jouenne, Marcel Salanoubat, Adrien Debard, Jean-Louis Petit, Marielle Lemaire, Stessy Nepert, Virginie Pellouin, Aline Mariage, Christine Guérard-Hélaine, Anne Zaparucha, Carine Vergne-Vaxelaire
Publikováno v: Applied Microbiology and Biotechnology
Applied Microbiology and Biotechnology, 2018, 102 (13), pp.5569-5583. ⟨10.1007/s00253-018-9018-1⟩
Applied Microbiology and Biotechnology, Springer Verlag, 2018, 102 (13), pp.5569-5583. ⟨10.1007/s00253-018-9018-1⟩
International audience; Most of the Brepressor, open reading frame, kinase^(ROK) proteins already characterized so far, and exhibiting a kinase activity, take restrictedly D-glucose as substrate. By exploring the sequenced bacterial diversity, 61 ATP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7d5c878432e05f2d43b3ebe500ab6f
https://hal.science/hal-02323767/file/Vergne-2018.pdf
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