Výsledky vyhledávání - "Aurélie Durand"

Akademický článek

Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice

Autor: Aurélie Durand, Nelly Bonilla, Théo Level, Zoé Ginestet, Amélie Lombès, Vincent Guichard, Mathieu Germain, Sébastien Jacques, Franck Letourneur, Marcio Do Cruzeiro, Carmen Marchiol, Gilles Renault, Morgane Le Gall, Céline Charvet, Agnès Le Bon, Bruno Martin, Cédric Auffray, Bruno Lucas

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Foxo family transcription factors are critically involved in multiple processes, such as metabolism, quiescence, cell survival and cell differentiation. Although continuous, high activity of Foxo transcription factors extends the life span o

Externí odkaz: https://doaj.org/article/1522e57409074b918800d251389fd226

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Akademický článek

Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota

Autor: Aurélie Durand, Alexandra Audemard-Verger, Vincent Guichard, Raphaël Mattiuz, Arnaud Delpoux, Pauline Hamon, Nelly Bonilla, Matthieu Rivière, Jérôme Delon, Bruno Martin, Cédric Auffray, Alexandre Boissonnas, Bruno Lucas

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Non-circulating, tissue-resident T cells have been reported for non-lymphoid organs, but their characterization and regulation in secondary lymphoid organs (SLO) are still lacking. Here the authors show that age and microbiota both exert SLO-specific

Externí odkaz: https://doaj.org/article/6817c7ab4e8648ea9360a32bfd190459

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Akademický článek

Calcium-mediated shaping of naive CD4 T-cell phenotype and function

Autor: Vincent Guichard, Nelly Bonilla, Aurélie Durand, Alexandra Audemard-Verger, Thomas Guilbert, Bruno Martin, Bruno Lucas, Cédric Auffray

Publikováno v: eLife, Vol 6 (2017)

Continuous contact with self-major histocompatibility complex ligands is essential for the survival of naive CD4 T cells. We have previously shown that the resulting tonic TCR signaling also influences their fate upon activation by increasing their a

Externí odkaz: https://doaj.org/article/94567a29547547ca9924e9be8b13ab44

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Driving Role of Interleukin‐2–Related Regulatory CD4 + T Cell Deficiency in the Development of Lung Fibrosis and Vascular Remodeling in a Mouse Model of Systemic Sclerosis

Autor: Camelia Frantz, Anne Cauvet, Aurélie Durand, Virginie Gonzalez, Rémi Pierre, Marcio Do Cruzeiro, Karine Bailly, Muriel Andrieu, Cindy Orvain, Jérôme Avouac, Mina Ottaviani, Raphaël Thuillet, Ly Tu, Christophe Guignabert, Bruno Lucas, Cédric Auffray, Yannick Allanore

Publikováno v: Arthritis & Rheumatology. 74:1387-1398

Systemic sclerosis (SSc) is a debilitating autoimmune disease characterized by severe lung outcomes resulting in reduced life expectancy. Fra-2-transgenic mice offer the opportunity to decipher the relationships between the immune system and lung fib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9377f0dbaa0e27ae50af396a1dba7e8
https://doi.org/10.1002/art.42111

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Signaling pathway deregulation and molecular alterations across pediatric medulloblastomas

Autor: Natacha Entz-Werle, Benoit Lhermitte, Anne-Florence Blandin, E. Guerin, Aurélie Durand, Andres Coca

Publikováno v: Neurochirurgie. 67:39-45

Medulloblastomas (MBs) account for 15% of brain tumors in children under the age of 15. To date, the overall 5-year survival rate for all children is only around 60%. Recent advances in cancer genomics have led to a fundamental change in medulloblast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff59e7a181f354348c024c1b9d1b861a
https://doi.org/10.1016/j.neuchi.2018.01.003

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Regulatory T Cell Stability and Migration Are Dependent on mTOR

Autor: Bruno Lucas, Ivan Nemazanyy, Sylvie Grégoire, Benoît L. Salomon, Emilie Ronin, Aurélie Durand, Salomé Glauzy, Martina Lubrano di Ricco, Jordane Divoux, Romain Vallion, Delphine Fradin, Yannis Lombardi

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2020, 205 (7), pp.1799-1809. ⟨10.4049/jimmunol.1901480⟩
Journal of Immunology, 2020, 205 (7), pp.1799-1809. ⟨10.4049/jimmunol.1901480⟩

CD4+ Foxp3+ regulatory T cells (Treg) are essential to maintain immune tolerance, as their loss leads to a fatal autoimmune syndrome in mice and humans. Conflicting findings have been reported concerning their metabolism. Some reports found that Treg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d9267abb3e3f2c64dc465af34893a4
https://pubmed.ncbi.nlm.nih.gov/32839235

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Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota

Autor: Bruno Lucas, Alexandre Boissonnas, Vincent Guichard, Aurélie Durand, Jérôme Delon, Nelly Bonilla, Matthieu Rivière, Arnaud Delpoux, Bruno Martin, Cédric Auffray, Pauline Hamon, Alexandra Audemard-Verger, Raphaël Mattiuz

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications, 2018, 9 (1), pp.68. ⟨10.1038/s41467-017-02458-4⟩

Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoid-resident T cell pool has not yet been done. Here we show that a subst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8eba74a0edcc4a27eac03f0e97c7a3
http://link.springer.com/article/10.1038/s41467-017-02458-4

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Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric

Autor: Anne-Florence, Blandin, Aurélie, Durand, Marie, Litzler, Aurélien, Tripp, Éric, Guérin, Elisa, Ruhland, Adeline, Obrecht, Céline, Keime, Quentin, Fuchs, Damien, Reita, Benoit, Lhermitte, Andres, Coca, Chris, Jones, Isabelle Lelong, Rebel, Pascal, Villa, Izzie Jacques, Namer, Monique, Dontenwill, Dominique, Guenot, Natacha, Entz-Werle

Publikováno v: Cancers

Background: Pediatric high-grade gliomas (pHGGs) are facing a very dismal prognosis and representative pre-clinical models are needed for new treatment strategies. Here, we examined the relevance of collecting functional, genomic, and metabolomics da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::698f85918e702f34406d7c0c154ea124
https://pubmed.ncbi.nlm.nih.gov/31779235

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PCLN-08. IN VITRO MODELING OF TUMOR DISSEMINATION FROM HYPOXIC PRIMARY DERIVED CELL LINES (PDCL) SPHEROIDS RECAPITULATED TUMOR DEVELOPMENT AND PROGRESSION IN PATIENTS

Autor: Monique Dontenwill, Anne Florence Blandin, Aurélie Durand, Eric Guérin, Isabelle Lelong-Rebel, Natacha Entz-Werle

Children diagnosed for brain tumors are facing variant prognoses depending mostly on the histological subtypes and their molecular characteristics. Nevertheless, more and more evidence is accumulating on the diffuse infiltrative growth pattern of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9912637483cfa4cbf87bd0abd58e3a53
https://europepmc.org/articles/PMC6012136/

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