Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Aurélie Dechaume"'
Autor:
Sarah Meulebrouck, Judith Merrheim, Gurvan Queniat, Cyril Bourouh, Mehdi Derhourhi, Mathilde Boissel, Xiaoyan Yi, Alaa Badreddine, Raphaël Boutry, Audrey Leloire, Bénédicte Toussaint, Souhila Amanzougarene, Emmanuel Vaillant, Emmanuelle Durand, Hélène Loiselle, Marlène Huyvaert, Aurélie Dechaume, Victoria Scherrer, Piero Marchetti, Beverley Balkau, Guillaume Charpentier, Sylvia Franc, Michel Marre, Ronan Roussel, Raphaël Scharfmann, Miriam Cnop, Mickaël Canouil, Morgane Baron, Philippe Froguel, Amélie Bonnefond
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Functional genetics has identified drug targets for metabolic disorders. Opioid use impacts metabolic homeostasis, although mechanisms remain elusive. Here, we explore the OPRD1 gene (encoding delta opioid receptor, DOP) to understand its im
Externí odkaz:
https://doaj.org/article/78b374b3ff9b43728d9fb6ee8aab174e
Autor:
Julien Philippe, Mehdi Derhourhi, Emmanuelle Durand, Emmanuel Vaillant, Aurélie Dechaume, Iandry Rabearivelo, Véronique Dhennin, Martine Vaxillaire, Franck De Graeve, Olivier Sand, Philippe Froguel, Amélie Bonnefond
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143373 (2015)
Molecular diagnosis of monogenic diabetes and obesity is of paramount importance for both the patient and society, as it can result in personalized medicine associated with a better life and it eventually saves health care spending. Genetic clinical
Externí odkaz:
https://doaj.org/article/2b0b009e644741e28638de85dfe3711c
Autor:
Amélie Bonnefond, Pierre-Jean Saulnier, Maria G Stathopoulou, Niels Grarup, Ndeye Coumba Ndiaye, Ronan Roussel, Mohsen Azimi Nezhad, Aurélie Dechaume, Olivier Lantieri, Serge Hercberg, Torsten Lauritzen, Beverley Balkau, Julia S El-Sayed Moustafa, Torben Hansen, Oluf Pedersen, Philippe Froguel, Guillaume Charpentier, Michel Marre, Samy Hadjadj, Sophie Visvikis-Siest
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55921 (2013)
Vascular endothelial growth factor (VEGF) is a key chemokine involved in tissue growth and organ repair processes, particularly angiogenesis. Elevated circulating VEGF levels are believed to play a role in type 2 diabetes (T2D) microvascular complica
Externí odkaz:
https://doaj.org/article/65d92f069f474f9ba018262a99f82b27
Autor:
Philippe Froguel, Ndeye Coumba Ndiaye, Amélie Bonnefond, Nabila Bouatia-Naji, Aurélie Dechaume, Gérard Siest, Bernard Herbeth, Mario Falchi, Leonardo Bottolo, Rosa-Maria Guéant-Rodriguez, Cécile Lecoeur, Michel R Langlois, Yann Labrune, Aimo Ruokonen, Said El Shamieh, Maria G Stathopoulou, Anita Morandi, Claudio Maffeis, David Meyre, Joris R Delanghe, Peter Jacobson, Lars Sjöström, Lena M S Carlsson, Andrew Walley, Paul Elliott, Marjo-Riita Jarvelin, George V Dedoussis, Sophie Visvikis-Siest
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32327 (2012)
Haptoglobin is an acute phase inflammatory marker. Its main function is to bind hemoglobin released from erythrocytes to aid its elimination, and thereby haptoglobin prevents the generation of reactive oxygen species in the blood. Haptoglobin levels
Externí odkaz:
https://doaj.org/article/cec641e79e79442fb737a5472b95a662
Whole-exome sequencing and high throughput genotyping identified KCNJ11 as the thirteenth MODY gene.
Autor:
Amélie Bonnefond, Julien Philippe, Emmanuelle Durand, Aurélie Dechaume, Marlène Huyvaert, Louise Montagne, Michel Marre, Beverley Balkau, Isabelle Fajardy, Anne Vambergue, Vincent Vatin, Jérôme Delplanque, David Le Guilcher, Franck De Graeve, Cécile Lecoeur, Olivier Sand, Martine Vaxillaire, Philippe Froguel
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37423 (2012)
BACKGROUND: Maturity-onset of the young (MODY) is a clinically heterogeneous form of diabetes characterized by an autosomal-dominant mode of inheritance, an onset before the age of 25 years, and a primary defect in the pancreatic beta-cell function.
Externí odkaz:
https://doaj.org/article/fb62a9cc488c43c0aac3eab59593d5c0
Autor:
Nicolas Cornière, R Brent Thomson, Stéphanie Thauvin, Bruno O Villoutreix, Sophie Karp, Diane W Dynia, Sarah Burlein, Lennart Brinkmann, Alaa Badreddine, Aurélie Dechaume, Mehdi Derhourhi, Emmanuelle Durand, Emmanuel Vaillant, Philippe Froguel, Régine Chambrey, Peter S Aronson, Amélie Bonnefond, Dominique Eladari
Publikováno v:
Journal of Medical Genetics. 59:1035-1043
BackgroundNephrolithiasis (NL) is a complex multifactorial disease affecting up to 10%–20% of the human population and causing a significant burden on public health systems worldwide. It results from a combination of environmental and genetic facto
Autor:
Lauriane Le Collen, Brigitte Delemer, Christine Poitou, Martine Vaxillaire, Bénédicte Toussaint, Aurélie Dechaume, Alaa Badreddine, Mathilde Boissel, Mehdi Derhourhi, Karine Clément, Jean M. Petit, Frédéric Tran Mau-Them, Ange-Line Bruel, Christel Thauvin-Robinet, Alexandru Saveanu, Blandine Gatta Cherifi, Johanne Le Beyec-Le Bihan, Philippe Froguel, Amélie Bonnefond
Publikováno v:
Genetics in Medicine. 25:100857
Autor:
Elizabeth T. Cirulli, Nicole L. Washington, Mickaël Canouil, Guillaume Charpentier, Emmanuelle Durand, Jean-Michel Borys, Alexandre Bolze, Franck De Graeve, Aurélie Dechaume, David Le Guilcher, Beverley Balkau, Sylvia Franc, Frédéric Allegaert, Ronan Roussel, Emmanuel Vaillant, Philippe Froguel, Gai Elhanan, Stefan Gaget, Joseph J. Grzymski, Loic Yengo, Véronique Dhennin, Amélie Bonnefond, James T. Lu, M Vaxillaire, Mathilde Boissel, Michel Marre, Bénédicte Toussaint
Publikováno v:
Nature Metabolism
Nature Metabolism, Nature Publishing Group, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
Nature Metabolism, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
Nature Metabolism, Nature Publishing Group, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
Nature Metabolism, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
International audience; Genome-wide association studies have identified 240 independent loci associated with type 2 diabetes (T2D) risk, but this knowledge has not advanced precision medicine. In contrast, the genetic diagnosis of monogenic forms of
Autor:
Cécile Aubert, Maithé Tauber, Ronan Roussel, Bénédicte Toussaint, François Pattou, Philippe Froguel, Jean-Michel Borys, Amjad Ghulam, Hélène Loiselle, Mathilde Boissel, Emmanuelle Durand, Sylvia Franc, Julie Kerr-Conte, Julie Maillet, Morgane Baron, Marlène Huyvaert, Amélie Bonnefond, Raphaël Boutry, J. Philippe, Jérémy Thomas, Guillaume Charpentier, Claire Lévy-Marchal, Michel Marre, Mehdi Derhourhi, Aurélie Dechaume, Emmanuel Vaillant, B. Balkau, Stefan Gaget, Raphael Scharfmann, Jacques Weill, Mickaël Canouil
Publikováno v:
Nature Medicine
Nature Medicine, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
Nature medicine
Nature Medicine, Nature Publishing Group, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
Nature Medicine, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
Nature medicine
Nature Medicine, Nature Publishing Group, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
International audience; The G-protein-coupled receptor accessory protein MRAP2 is implicated in energy control in rodents, notably via the melanocortin-4 receptor1. Although some MRAP2 mutations have been described in people with obesity1-3, their fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e4070864d7e526bb4fbf52762499c4
https://www.hal.inserm.fr/inserm-02439220/document
https://www.hal.inserm.fr/inserm-02439220/document
Autor:
Amélie, Bonnefond, Loïc, Yengo, Aurélie, Dechaume, Mickaël, Canouil, Maxime, Castelain, Estelle, Roger, Frédéric, Allegaert, Robert, Caiazzo, Violeta, Raverdy, Marie, Pigeyre, Abdelilah, Arredouani, Jean-Michel, Borys, Claire, Lévy-Marchal, Jacques, Weill, Ronan, Roussel, Beverley, Balkau, Michel, Marre, François, Pattou, Thierry, Brousseau, Philippe, Froguel
Publikováno v:
BMC Medicine
BMC Medicine, 2016, 15 (1), pp.37. ⟨10.1186/s12916-017-0784-x⟩
BMC Medicine, BioMed Central, 2016, 15 (1), pp.37. 〈10.1186/s12916-017-0784-x〉
BMC Medicine, BioMed Central, 2016, 15 (1), pp.37. ⟨10.1186/s12916-017-0784-x⟩
BMC Medicine, 2016, 15 (1), pp.37. ⟨10.1186/s12916-017-0784-x⟩
BMC Medicine, BioMed Central, 2016, 15 (1), pp.37. 〈10.1186/s12916-017-0784-x〉
BMC Medicine, BioMed Central, 2016, 15 (1), pp.37. ⟨10.1186/s12916-017-0784-x⟩
Background Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of AMY1A (encoding AMY1) was reported to be higher in populations with a high-starch diet and reduced in obese people. These results based on quantitative PCR hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3084a1c580d6f8970227a5e0287daa7f
http://hdl.handle.net/10044/1/45810
http://hdl.handle.net/10044/1/45810