Heart rate reduction after genetic ablation of L-type Cav1.3 channels induces cardioprotection against ischemia-reperfusion injury

Autor: Viviana Delgado-Betancourt, Kroekkiat Chinda, Pietro Mesirca, Christian Barrère, Aurélie Covinhes, Laura Gallot, Anne Vincent, Isabelle Bidaud, Sarawut Kumphune, Joël Nargeot, Christophe Piot, Kevin Wickman, Matteo Elia Mangoni, Stéphanie Barrère-Lemaire

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

BackgroundAcute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Most ischemic episodes are triggered by an increase in heart rate, which induces an imbalance between myocardial oxygen delivery and consumption. De

Externí odkaz: https://doaj.org/article/a970e246abbf4797bacbe5953a306b1b

TD peptide as an adjunct of reperfusion therapy provides long-term cardioprotective effects in a mouse model of ischemia-reperfusion

Autor: Christophe Piot, L. Gallot, Joël Nargeot, Christian Barrère, S. Barrere-Lemaire, Aurélie Covinhes, Catherine Sportouch, Prisca Boisguerin, Bernard Lebleu, Anne Vincent

Publikováno v: e-Printemps de la Cardiologie 2021
e-Printemps de la Cardiologie 2021, May 2021, econgres, France. 13 (2), pp.202, 2021, ⟨10.1016/j.acvdsp.2021.04.133⟩

International audience; Introduction: During myocardial infarction (MI), reperfusion therapy leads to side effects called ischemia-reperfusion (IR) injury for which no treatment exists. While most studies have targeted the intrinsic apoptotic pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb4364979258b3730d59c611e70e3d2
https://hal.umontpellier.fr/hal-03429860

Cardioprotective effect of the TD anti-apoptotic peptide: Study of the mechanisms of action

Autor: Anne Vincent, Christian Barrère, Aurélie Covinhes, Laura Gallot, Christophe Piot, C. Fernandez-Rico, Stéphanie Barrère-Lemaire, Joël Nargeot, Bernard Lebleu, Prisca Boisguerin

Publikováno v: Archives of Cardiovascular Diseases Supplements
Printemps de la Cardiologie
Printemps de la Cardiologie, Oct 2020, Grenoble (E-meeting), France. Elsevier/French Society of Cardiology, 12 (2-4), pp.228-229, 2020, Archives of Cardiovascular Disease Supplements. ⟨10.1016/j.acvdsp.2020.03.072⟩

International audience; Introduction: Apoptosis is a main contributor of reperfusion injury after myocardial infarction. In a previous study, we evidenced the cardioprotective effect of a synthetic peptide (TD) able to interfere with FAS-DAXX interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb0eb7b85be3120ed552a28b1632cc8
https://hal.archives-ouvertes.fr/hal-03015716

Cardioprotective effects of a synthetic peptide targeting the extrinsic apoptotic pathway in a mouse model of ischemia-reperfusion

Autor: Muriel Busson, Anne Vincent, Christophe Piot, Christian Barrère, Joël Nargeot, Stéphanie Barrère-Lemaire, Bernard Lebleu, Aurélie Covinhes, Laura Gallot, Prisca Boisguerin

Publikováno v: Archives of cardiovascular diseases
Archives of cardiovascular diseases, Elsevier/French Society of Cardiology, 2019, 11 (2), pp.211. ⟨10.1016/j.acvdsp.2019.02.065⟩

Introduction Apoptosis is a main contributor of myocardial reperfusion injury during acute infarction. In a previous study, we showed that reperfusion injury was mediated by the FAS-dependent apoptotic signal mobilizing the DAXX (death-associated pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e139dfddaa9a34e50cbafb906daf51
https://hal.archives-ouvertes.fr/hal-02404659

PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo

Autor: S. Barrere-Lemaire, Gudrun Aldrian, Hélène Déméné, Véronique Viguier, Karidia Konate, Eric Vivès, Franck Couillaud, Dina Aggad, Quentin Seisel, Anaïs Vaissière, Coralie Genevois, Frédéric Fernandez, Sébastien Deshayes, Prisca Boisguerin, Aurélie Covinhes

Publikováno v: Journal of Controlled Release
Journal of Controlled Release, Elsevier, 2017, 256, pp.79-91. ⟨10.1016/j.jconrel.2017.04.012⟩

Small interfering RNAs (siRNAs) present a strong therapeutic potential because of their ability to inhibit the expression of any desired protein. Recently, we developed the retro-inverso amphipathic RICK peptide as novel non-covalent siRNA carrier. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b3178351d3f6aa0c3769d891d64be7
https://pubmed.ncbi.nlm.nih.gov/28411182