Výsledky vyhledávání - "Aurélie Collignon"

Akademický článek

Deciphering the Crosstalk Between Myeloid-Derived Suppressor Cells and Regulatory T Cells in Pancreatic Ductal Adenocarcinoma

Autor: Carole Siret, Aurélie Collignon, Françoise Silvy, Stéphane Robert, Thierry Cheyrol, Perrine André, Véronique Rigot, Juan Iovanna, Serge van de Pavert, Dominique Lombardo, Eric Mas, Anna Martirosyan

Publikováno v: Frontiers in Immunology, Vol 10 (2020)

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with rising incidence and a remarkable resistance to current therapies. The reasons for this therapeutic failure include the tumor's extensive infiltration by immunosuppressive cells such as

Externí odkaz: https://doaj.org/article/521dadb697b543e381156702c22814fb

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Akademický článek

Dendritic cell-based vaccination: powerful resources of immature dendritic cells against pancreatic adenocarcinoma

Autor: Aurélie Collignon, Françoise Silvy, Stéphane Robert, Malika Trad, Sébastien Germain, Jérémy Nigri, Frédéric André, Véronique Rigot, Richard Tomasini, Bernard Bonnotte, Dominique Lombardo, Eric Mas, Evelyne Beraud

Publikováno v: OncoImmunology, Vol 7, Iss 12 (2018)

Pancreatic adenocarcinoma (PAC) has a poor prognosis. One treatment approach, investigated here, is to reinforce antitumor immunity. Dendritic cells (DCs) are essential for the development and regulation of adaptive host immune responses against tumo

Externí odkaz: https://doaj.org/article/64caf32902694b35a6197ca1d25f0fab

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Abstract 4624: Deciphering the tumor microenvironment at single-cell resolution using a workflow combining RNA transcript and protein detection with Brightplex®, a sequential chromogenic multiplex assay

Autor: Alex Trinh, Marion Olive, Aurélie Collignon, Maité Chamourin, Georgia Culley, Clemence Jaume, Vanina Leca, Assil Benchaaben, Giovanni Bussotti, Alboukadel Kassambara, Jerome Galon, Jacques Fieschi

Publikováno v: Cancer Research. 83:4624-4624

Tumor-infiltrating immune cells play an important role against cancer and are critical to control tumor growth and spread. Immunotherapy and immune checkpoint blockade, which aim to reinvigorate exhausted T cells have revolutionized cancer therapy. D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c33028ec47e5b977252cd321bcacbc23
https://doi.org/10.1158/1538-7445.am2023-4624

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41 Assessment of the spatial distribution of CD4+ T cells subpopulations in the tumor microenvironment by Brightplex®, a sequential chromogenic multiplex assay

Autor: Christophe Haond, Clémence Jaume, Dylan Anselmo, Georgia Culey, Raana Ramouz-Charpentier, Marion Olive, Aurélie Collignon, Nour Sfeir, Jérôme Galon, Maïté Chamourin, Alex Trinh, Jacques Fieschi-Meric

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundCancer immunotherapy reinvigorates tumor-specific T cell responses of CD8+ cytotoxic T lymphocytes that detect intracellular antigens that are presented by MHC class I molecules expressed by all tumor cell types. Because most tumors do not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aadb2c3f00407d46849995479f90b70
https://doaj.org/article/ce515bad97d34972b4d29e0d2c75c7e6

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Pancreatic adenocarcinoma, chronic pancreatitis, and MODY-8 diabetes: is bile salt-dependent lipase (or carboxyl ester lipase) at the crossroads of pancreatic pathologies?

Autor: Françoise Silvy, Aurélie Collignon, Dominique Lombardo, Emmanuelle Martinez, Evelyne Beraud, Isabelle Crenon, Eric Mas

Publikováno v: Oncotarget

// Dominique Lombardo 1 , Francoise Silvy 1 , Isabelle Crenon 1 , Emmanuelle Martinez 1 , Aurelie Collignon 1 , Evelyne Beraud 1 and Eric Mas 1 1 Aix Marseille Univ, INSERM, CRO2, Centre de Recherche en Oncologie Biologique et Oncopharmacologie, Mars

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd384eaba695c9e7774f607452a8d1d0
http://europepmc.org/articles/PMC5844766

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57 Assessment of the spatial distribution of B cells subpopulations in the tumor microenvironment and tertiary lymphoid structures by Brightplex®, a sequential chromogenic multiplex assay

Autor: Alex Trinh, Jérôme Galon, Dylan Anselmo, Jacques Fieschi-Meric, Marion Olive, Clémence Jaume, Nour Sfeir, Maïté Chamourin, Christophe Haond, Raana Ramouz-Charpentier, Georgia Culey, Aurélie Collignon

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundDensity and localization of T cells within the tumor microenvironment (TME) is critical to control tumor growth. Immunotherapy with antibodies against immune checkpoint inhibitors (ICI), which aim to reinvigorate exhausted T cells, despite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6210c830c0844ea2ee4a7d9b2b4a6f
https://doi.org/10.1136/jitc-2021-sitc2021.057

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Abstract 2796: Validation of Brightplex, a multiplexed IHC solution for immune cell phenotyping of the tumor microenvironment

Autor: Aurélie Collignon, Assil Benchaaben, Alboukadel Kassambara, Felipe Guimaraes, Emmanuel Prestat, Christophe Haond, Jacques Fieschi

Publikováno v: Cancer Research. 79:2796-2796

Brightplex is a multiplexing solution developed by HalioDx to analyze the tumor microenvironment on FFPE tissue. It leverages chromogenic immunohistochemistry performed by iterative automated immunostaining on the same slide followed by whole slide d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::869638e819be1bc2302c32c6a09a05b4
https://doi.org/10.1158/1538-7445.am2019-2796

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Abstract A182: T-cell exhaustion assessment using a fully automated sequential chromogenic multiplex assay

Autor: Jacques Fieschi, Christophe Haond, Aurélie Collignon, Anna Martirosyan, Assil Benchaaben, Emilie Bonzom, Emmanuel Prestat, Matthieu Duval

Publikováno v: Cancer Immunology Research. 7:A182-A182

Cancer immunotherapy by anti-PD-1 or anti-PD-L1 antibodies is now established as an efficient approach to restore the cytotoxic activity of exhausted T-cells. However, the strong and durable response observed in non-small cell lung cancer (NSCLC) pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55665e433b2c958a16e462d450348d89
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a182

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Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer

Autor: Evelyne Beraud, Dominique Lombardo, Aurélie Collignon, Eric Mas, Cécile Franceschi, Daniel Olive

Publikováno v: Oncoimmunology

Glycoproteins, as valuable targets for dendritic cell (DC)-vaccination in cancers, remain an open question. Glycosylated structures, which are aberrantly modified during cancerisation, impact positively or negatively on glycoprotein immunogenicity. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d36fd5b5bfa2aa54e6fd94eae5dea7
https://doi.org/10.4161/onci.1.1.18459

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