Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission

Autor: Camilla Luiza-Batista, Sabine Thiberge, Malika Serra-Hassoun, Flore Nardella, Aurélie Claës, Vanessa C. Nicolete, Pierre-Henri Commère, Liliana Mancio-Silva, Marcelo U. Ferreira, Artur Scherf, Sylvie Garcia

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)

Plasmodium vivax is the most widespread human malaria parasite but due to its tropism for immature red blood cells in vitro culturing and studies are difficult. Here, LuizaBatista et al. generate a humanized mouse supporting human erythropoiesis and

Externí odkaz: https://doaj.org/article/efe541ad29ea4364a4ae5568530e9226

Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA.

Autor: Dominique Dorin-Semblat, Marilou Tétard, Aurélie Claës, Jean-Philippe Semblat, Sébastien Dechavanne, Zaineb Fourati, Romain Hamelin, Florence Armand, Graziella Matesic, Sofia Nunes-Silva, Anand Srivastava, Stéphane Gangnard, Jose-Juan Lopez-Rubio, Marc Moniatte, Christian Doerig, Artur Scherf, Benoît Gamain

Publikováno v: PLoS Biology, Vol 17, Iss 6, p e3000308 (2019)

Plasmodium falciparum is the main cause of disease and death from malaria. P. falciparum virulence resides in the ability of infected erythrocytes (IEs) to sequester in various tissues through the interaction between members of the polymorphic P. fal

Externí odkaz: https://doaj.org/article/99d6e1fa67c54645ad05654594299565

Quinazoline-quinoline bisubstrate inhibitors target eukaryotic translation initiation factor 3 inPlasmodium falciparum

Autor: Irina Dobrescu, Elie Hammam, Jerzy M. Dziekan, Aurélie Claës, Ludovic Halby, Peter Preiser, Zbynek Bozdech, Paola B. Arimondo, Artur Scherf, Flore Nardella

Malaria drug resistance is hampering the fight against the deadliest parasitic disease affecting over 200 million people worldwide. We recently developed quinoline-quinazoline-based inhibitors (as compound70) as promising new antimalarials. Here we a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a5914a9be3e5e0b6b87843c606f2fef
https://doi.org/10.1101/2022.12.10.519887

Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism

Autor: Jérôme Fagart, Lucie Pujo, Françoise Gary, Xavier Jeunemaitre, Maria-Christina Zennaro, Dimitris T. Papadimitriou, Aurélie Claës

Publikováno v: Hum Mutat
Hum Mutat, 2006, 0, pp.1-8. ⟨10.1002/humu.20371⟩
Hum Mutat, 2006, pp.1-8. ⟨10.1002/humu.20371⟩
Hum Mutat, 2006, 0, pp.1-8. 〈10.1002/humu.20371〉

Aldosterone plays a key role in electrolyte balance and blood pressure regulation. Type 1 pseudohypoaldosteronism (PHA1) is a primary form of mineralocorticoid resistance characterized in the newborn by salt wasting, hyperkalemia, and failure to thri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85df7076d53f337f3f5e77964cd27da
https://www.hal.inserm.fr/inserm-00096814

Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite.

Autor: Bryant, Jessica M^1,2,3 (AUTHOR) jessica.bryant@pasteur.fr, Baumgarten, Sebastian^1,2,3 (AUTHOR), Dingli, Florent⁴ (AUTHOR), Loew, Damarys⁴ (AUTHOR), Sinha, Ameya^5,6 (AUTHOR), Claës, Aurélie^1,2,3 (AUTHOR), Preiser, Peter R^5,6 (AUTHOR), Dedon, Peter C^6,7 (AUTHOR), Scherf, Artur^1,2,3 (AUTHOR)

Publikováno v: Molecular Systems Biology. Aug2020, Vol. 16 Issue 8, p1-22. 22p.