Výsledky vyhledávání - "Aurélie Candi"

Abstract 4964: SW-682: A novel TEAD inhibitor for the treatment of cancers bearing mutations in the Hippo signaling pathway

Autor: Lei Chen, Paula Milani de Marval, Kendall Powell, Mark Johnson, Greg Falls, Brian Lawhorn, Aurélie Candi, Amuri Kilonda, Bart Vanderhoydonck, Arnaud Marchand, Matthias Versele, Georg Halder, Stephen L. Gwaltney, Adeela Kamal

Publikováno v: Cancer Research. 83:4964-4964

Many cancers harbor mutations in the Hippo pathway that lead to constitutive activation of the transcriptional co-activators YAP/TAZ that then bind the transcription factor TEAD and drive aberrant transcription of target genes involved in cell prolif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff72fff7f3b3f1feb5934f47b68973aa
https://doi.org/10.1158/1538-7445.am2023-4964

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Abstract 3945: Novel antagonists of TEAD palmitoylation inhibit the growth of Hippo-altered cancers in preclinical models

Autor: Adeela Kamal, Aurélie Candi, Matthias Versele, Bart Vanderhoydonck, Arnaud Marchand, Ron de Jong, Thuy Hoang, Georg Halder, Patrick Chaltin, Stephen L. Gwaltney, Mike Burgess

Publikováno v: Cancer Research. 82:3945-3945

Background: The Hippo pathway is an evolutionarily conserved signaling cascade whose deregulation can promote excessive cell proliferation and tumor development. Pathway output is mediated by the YAP and TAZ transcriptional co-activators, which bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c4509ba65fd9177d8f75b5e6f63729b
https://doi.org/10.1158/1538-7445.am2022-3945

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Abstract 5229: Discovery of novel potent allosteric inhibitors of YAP/TAZ-TEAD transcription for the treatment of multiple solid tumor types addicted to Hippo signaling

Autor: Leticia Sansores, Matthias Versele, Bart Vanderhoydonck, Wim Smets, Aurélie Candi, Arnaud Marchand, Wanda Haeck, Marnik Nijs, Patrick Chaltin, Georg Halder, Stéphane Spieser, Hugo Klaassen

Publikováno v: Cancer Research. 80:5229-5229

The Hippo pathway is a highly conserved signaling pathway across higher-order vertebrates and a key modulator of developmental biology. Both genetic aberrations as well as non-genetic dysregulation of the pathway lead to constitutive nuclear localiza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62badb1cf6daa846dd8476b80c4ab733
https://doi.org/10.1158/1538-7445.am2020-5229

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Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems

Autor: Bart Jonckx, Michaël Porcu, Philippe Barbeaux, Isabelle Etienne, Jean H.M. Feyen, Aurélie Candi

Publikováno v: Journal of Ophthalmology, Vol 2017 (2017)
Journal of Ophthalmology

Ocriplasmin (Jetrea®) is a recombinant protease used to treat vitreomacular traction. To gain insight into vitreoretinal observations reported after ocriplasmin treatment, we have developed anin vivoporcine ocriplasmin-induced posterior vitreous det

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A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours

Autor: Aurélie Candi, Peter Carmeliet, Steven Goossens, Benjamin Beck, Guilhem Mascré, Amélie Caauwe, Panagiota A. Sotiropoulou, Anna Kuchnio, Benjamin Drogat, Gaëlle Lapouge, Khalil Kass Youssef, Cédric Blanpain, Jody J. Haigh, Gregory Driessens, Sophie Dekoninck, Sonja Loges

Publikováno v: Nature. 478:399-403

Angiogenesis is critical during tumour initiation and malignant progression. Different strategies aimed at blocking vascular endothelial growth factor (VEGF) and its receptors have been developed to inhibit angiogenesis in cancer patients. It has bec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb6edbfde3fcbf02919feeaa1c64e05
https://doi.org/10.1038/nature10525

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Microarray analyses of the effects of NF-κB or PI3K pathway inhibitors on the LPS-induced gene expression profile in RAW264.7 cells

Autor: Carine Munaut, Karim Zouaoui Boudjeltia, Marie-Rose Pignon, Hidde Bult, Martine Raes, Martine Vansteenbrugge, Sofia Dos Santos Mendes, Aurélie Candi

Publikováno v: Cellular Signalling. 21:1109-1122

Lipopolysaccharide (LPS) activates a broad range of signalling pathways including mainly NF-kappaB and the MAPK cascade, but recent evidence suggests that LPS stimulation also activates the PI3K pathway. To unravel the specific roles of both pathways

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19455ab2c910112bf5d31dace7df366e
https://doi.org/10.1016/j.cellsig.2009.02.025

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The Majority of Multipotent Epidermal Stem Cells Do Not Protect Their Genome by Asymmetrical Chromosome Segregation

Autor: Panagiota A. Sotiropoulou, Cédric Blanpain, Aurélie Candi

Publikováno v: Stem Cells. 26:2964-2973

The maintenance of genome integrity in stem cells (SCs) is critical for preventing cancer formation and cellular senescence. The immortal strand hypothesis postulates that SCs protect their genome by keeping the same DNA strand throughout life by asy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c6a55c345d37a04f9d97ab7e591d54
https://doi.org/10.1634/stemcells.2008-0634

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BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

Autor: Virginie Moers, Maud Debaugnies, Andrea E. Karambelas, Jos Jonkers, Kiyotoshi Sekiguchi, Cédric Blanpain, Peter Bouwman, Panagiota A. Sotiropoulou, Ana Rocha, Aurélie Candi, Tatiana Revenco

Panagiota A. Sotiropoulou, Andrea E. Karambelas, Maud Debaugnies, Aurelie Candi, Peter Bouwman, Virginie Moers, Tatiana Revenco, Ana Sofia Rocha, Kiyotoshi Sekiguchi, Jos Jonkers and Cedric Blanpain, "BRCA1 deficiency in skin epidermis leads to selec

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https://europepmc.org/articles/PMC3553282/

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Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death

Autor: Claudio Semeraro, Guilhem Mascré, Sarah De Clercq, Jean-Christophe Marine, Cédric Blanpain, Ellen Dahl, Gaëlle Lapouge, Khalil Kass Youssef, Panagiota A. Sotiropoulou, Geertrui Denecker, Aurélie Candi

Publikováno v: Nature cell biology. 12(6)

Adult stem cells (SCs) are at high risk of accumulating deleterious mutations because they reside and self-renew in adult tissues for extended periods. Little is known about how adult SCs sense and respond to DNA damage within their natural niche. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c083ebe409ef5c4cf201bfbaccd1af1b
https://pubmed.ncbi.nlm.nih.gov/20531424

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Microarray analyses of the effects of NF-kappaB or PI3K pathway inhibitors on the LPS-induced gene expression profile in RAW264.7 cells: synergistic effects of rapamycin on LPS-induced MMP9-overexpression

Autor: Sofia Dos Santos, Mendes, Aurélie, Candi, Martine, Vansteenbrugge, Marie-Rose, Pignon, Hidde, Bult, Karim Zouaoui, Boudjeltia, Carine, Munaut, Martine, Raes

Publikováno v: Cellular signalling. 21(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92b438a0f5047ae49119511ca2184953
https://pubmed.ncbi.nlm.nih.gov/19285553

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