Fully automated radiolabeling of [68Ga]Ga-EMP100 targeting c-MET for PET-CT clinical imaging

Autor: Timofei Rusu, Matthieu Delion, Charlotte Pirot, Amaury Blin, Anita Rodenas, Jean-Noël Talbot, Nicolas Veran, Christophe Portal, Françoise Montravers, Jacques Cadranel, Aurélie Prignon

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-15 (2023)

Abstract Background c-MET is a transmembrane receptor involved in many biological processes and contributes to cell proliferation and migration during cancer invasion process. Its expression is measured by immunehistochemistry on tissue biopsy in cli

Externí odkaz: https://doaj.org/article/bab6cc463ae84494ac324bab0640a6ad

A comparative study of peptide-based imaging agents [68Ga]Ga-PSMA-11, [68Ga]Ga-AMBA, [68Ga]Ga-NODAGA-RGD and [68Ga]Ga-DOTA-NT-20.3 in preclinical prostate tumour models

Autor: Jules Zhang-Yin, Mallaurie Penent, Françoise Montravers, Olivier Cussenot, Geraldine Cancel-Tassin, Eva Compérat, Jean-Noël Talbot, Timofei Rusu, Raphaële Renard-Penna, Camelia Radulescu, Aurélie Prignon, Claire Provost

Publikováno v: Nuclear Medicine and Biology
Nuclear Medicine and Biology, Elsevier, 2020, 84-85, pp.88-95. ⟨10.1016/j.nucmedbio.2020.03.005⟩

Introduction Peptide-based imaging agents targeting prostate-specific membrane antigen (PSMA) have revolutionized the evaluation of biochemical recurrence of prostate cancer (PCa) but lacks sensitivity at very low serum prostate specific antigen (PSA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e64d99ec50704fe13e7c3b9e934a8db
https://doi.org/10.1016/j.nucmedbio.2020.03.005

Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with 68 Ga-Labeled Antagonists: The Chelate Makes the Difference Again

Autor: Mélanie Guillemin, Pierre-Simon Bellaye, Franck Denat, Aurélie Prignon, Victor Goncalves, Emma Renard, Mathieu Moreau, Bertrand Collin

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (12), pp.8564-8578. ⟨10.1021/acs.jmedchem.1c00523⟩

Neurotensin receptor 1 (NTS1) is involved in the development and progression of numerous cancers, which makes it an interesting target for the development of diagnostic and therapeutic agents. A small molecule NTS1 antagonist, named [177Lu]Lu-IPN0108

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11600a1ea828363b7a3e1a659d0d687
https://hal.archives-ouvertes.fr/hal-03470823

The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma.

Autor: Quentin Raimbourg, Joëlle Perez, Sophie Vandermeersch, Aurélie Prignon, Guillaume Hanouna, Jean-Philippe Haymann, Laurent Baud, Emmanuel Letavernier

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e60469 (2013)

Conventional calpains are ubiquitous cysteine proteases whose activity is promoted by calcium signaling and specifically limited by calpastatin. Calpain expression has been shown to be increased in human malignant cells, but the contribution of the c

Externí odkaz: https://doaj.org/article/42f3f88893984d7eb06651f5fce0993a

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Autor: Yasmina Adimy, Christèle Combes, Hang-Korng Ea, Martine Cohen-Solal, Thomas Bardin, Jean-Pierre Riveline, Felix Renaudin, Lucie Orliaguet, Florence Castelli, Pascal Richette, Frédéric Lioté, François Fenaille, Nicolas Venteclef, Laure Campillo-Gimenez, Fawaz Alzaid, Aurélie Prignon, Aurélie Delvaux

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2020, 79 (11), pp.1506-1514. ⟨10.1136/annrheumdis-2020-217342⟩
Annals of the Rheumatic Diseases, 2020, 79 (11), pp.1506-1514. ⟨10.1136/annrheumdis-2020-217342⟩

ObjectiveMacrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and pseudo-gout flare, respectively. Since metabolic reprogramming of macrophages go

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc85ce496a2d99098e317f810d2250f
https://hal.archives-ouvertes.fr/hal-03203907