Phosphoinositide 3-kinase signalling in the nucleolus

Autor: Andrea Papdiné Morovicz, Fatemeh Mazloumi Gavgani, Rhîan G. Jacobsen, Malene Skuseth Slinning, Diana C. Turcu, Aurélia E. Lewis

Publikováno v: Advances in biological regulation. 83

The phosphoinositide 3-kinase (PI3K) signalling pathway plays key roles in many cellular processes and is altered in many diseases. The function and mode of action of the pathway have mostly been elucidated in the cytoplasm. However, many of the comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca89f5f98ba054c447c2cdba3461b949
https://pubmed.ncbi.nlm.nih.gov/34920983

Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins

Autor: Andrea Papdine Morovicz, Sandra Ninzima, Diana Cornelia Turcu, Malene Skuseth Slinning, Clive D'Santos, Aurélia E. Lewis, Fatemeh Mazloumi Gavgani, Victoria Smith Arnesen

Publikováno v: Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics

Polyphosphoinositides (PPIns) play essential roles as lipid signaling molecules, and many of their functions have been elucidated in the cytoplasm. However, PPIns are also intranuclear where they contribute to chromatin remodeling, transcription, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681700c62f516155bf3f4f055966ecfe
http://europepmc.org/articles/PMC8255942

Nuclear upregulation of PI3K p110β correlates with increased rRNA transcription in endometrial cancer cells

Autor: Fatemeh Mazloumi Gavgani, Victoria Smith Arnesen, Aurélia E. Lewis, Camilla Krakstad, Julie Guillermet-Guibert, Diana Cornelia Turcu, Thomas Karlsson, Andrea Papdine Morovicz, Ingvild L. Tangen

Genes encoding for components of the phosphoinositide 3-kinase (PI3K) pathway are frequently mutated in cancer, including inactivating mutations ofPTENand activating mutations ofPIK3CA, encoding the PI3K catalytic subunit p110α.PIK3CB, encoding p110

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006647e1d2e98b4a9e86cd17883e132f
https://doi.org/10.1101/2019.12.20.884122

Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer

Autor: Aurélia E. Lewis, Camilla Krakstad, Rhian Gaenor Jacobsen, Fatemeh Mazloumi Gavgani, Victoria Smith Arnesen, Erling A. Hoivik

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 12, p 3931 (2018)
International Journal of Molecular Sciences

The phosphoinositide 3-kinase (PI3K) signalling pathway is highly dysregulated in cancer, leading to elevated PI3K signalling and altered cellular processes that contribute to tumour development. The pathway is normally orchestrated by class I PI3K e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ee9165a414360b6e6f462616f63e19
https://www.mdpi.com/1422-0067/19/12/3931

PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer

Autor: Kanthida Kusonmano, Mari K. Halle, Anna Berg, Anne Margrete Øyan, Frederik Holst, Even Birkeland, Helga B. Salvesen, Ingvild L. Tangen, Gordon B. Mills, Karen Klepsland Mauland, Erling A. Hoivik, Camilla Krakstad, Karl-Henning Kalland, Jone Trovik, Henrica M.J. Werner, Siv Mjøs, Aurélia E. Lewis

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Mutations of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial cancer. We sequenced exon9 and exon20 of PIK3CA in 280 primary endometrial cancers to assess the relationship with clinicopathologic v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a63a142691c9f269368d0462a224c8
http://europepmc.org/articles/PMC5578954