Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Aulikki Koskinen"'
Autor:
Mohammed Alsharifi, Aulikki Koskinen, Danushka K Wijesundara, Jayaram Bettadapura, Arno Müllbacher
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68458 (2013)
MHCII molecules are heterodimeric cell surface proteins composed of an α and β chain. These molecules are almost exclusively expressed on thymic epithelium and antigen presenting cells (APCs) and play a central role in the development and function
Externí odkaz:
https://doaj.org/article/b06e3769da394153adb769bceaa0f62f
Autor:
Yoichi Furuya, Jennifer Chan, En-Chi Wan, Aulikki Koskinen, Kerrilyn R Diener, John D Hayball, Matthias Regner, Arno Müllbacher, Mohammed Alsharifi
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25765 (2011)
BACKGROUND: We have shown previously in mice, that infection with live viruses, including influenza/A and Semliki Forest virus (SFV), induces systemic partial activation of lymphocytes, characterized by cell surface expression of CD69 and CD86, but n
Externí odkaz:
https://doaj.org/article/ad2e61aeaf4142dda6b8c7ea03a54c3a
Autor:
Julián Pardo, Eva María Gálvez, Aulikki Koskinen, Markus M Simon, Mario Lobigs, Matthias Regner, Arno Müllbacher
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7512 (2009)
BACKGROUND: Ectromelia virus is a natural mouse pathogen, causing mousepox. The cytotoxic T (Tc) cell granule serine-protease, granzyme B, is important for its control, but the underlying mechanism is unknown. Using ex vivo virus immune Tc cells, we
Externí odkaz:
https://doaj.org/article/65498792f83d4665b5297cf371e14c8d
Autor:
Mohammed Alsharifi, Yoichi Furuya, Timothy R Bowden, Mario Lobigs, Aulikki Koskinen, Matthias Regner, Lee Trinidad, David B Boyle, Arno Müllbacher
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5336 (2009)
BACKGROUND: Influenza A (flu) virus causes significant morbidity and mortality worldwide, and current vaccines require annual updating to protect against the rapidly arising antigenic variations due to antigenic shift and drift. In fact, current subu
Externí odkaz:
https://doaj.org/article/d7df0ff886154443a74a919693951cdf
Autor:
Matthias Regner, Katrina Louise Scarff, Monica Devi Prakash, Carolina R. Melo-Silva, Aulikki Koskinen, Arno Müllbacher, Alexandra Rizzitelli, Jennii Luu, Matthew Mangan, Catherina H. Bird, Phillip I. Bird
Publikováno v:
Immunology & Cell Biology. 95:884-894
Intracellular serpins are proposed to inactivate proteases released from lysosome-related organelles into the host cell interior, preventing cell death. Serpinb9 opposes the immune cytotoxic protease, granzyme B, and in a number of settings protects
Autor:
Mario Lobigs, Arno Müllbacher, Aulikki Koskinen, Matthias Regner, Carolina R. Melo-Silva, David C. Tscharke
Publikováno v:
Virus Research. 228:61-65
Mousepox is caused by the orthopoxvirus ectromelia virus (ECTV), and is thought to be transmitted via skin abrasions. We studied the ECTV virulence factor N1 following subcutaneous infection of mousepox-susceptible BALB/c mice. In this model, ECTV la
Autor:
Paulus Mrass, Stephen J. Turner, Bosco K. Ho, Marcia A. Munoz, Matthew R. Olson, Philip L. Tong, Monica Devi Prakash, Aulikki Koskinen, Phillip I. Bird, Rohit Jain, Oded Kleifeld, Wolfgang Weninger, Matthias Regner
Publikováno v:
Immunity. 41:960-972
SummaryGranzyme B (GzmB) is a protease with a well-characterized intracellular role in targeted destruction of compromised cells by cytotoxic lymphocytes. However, GzmB also cleaves extracellular matrix components, suggesting that it influences the i
Autor:
Aulikki Koskinen, Carolina R. Melo-Silva, Mario Lobigs, David C. Tscharke, Arno Müllbacher, R. Mark L. Buller, Yik Chun Wong, Matthias Regner
Publikováno v:
Journal of Virology. 85:11170-11182
Ectromelia virus (ECTV) is a natural pathogen of mice that causes mousepox, and many of its genes have been implicated in the modulation of host immune responses. Serine protease inhibitor 2 (SPI-2) is one of these putative ECTV host response modifie
Autor:
Aulikki Koskinen, Mario Lobigs, Mohammed Alsharifi, Matthias Regner, Arno Müllbacher, Yoichi Furuya
Publikováno v:
Journal of General Virology. 91:1450-1460
We have recently shown that intranasal (i.n.) administration of gamma-irradiated A/PR/8 [A/Puerto Rico/8/34 (H1N1)] protects mice against lethal avian influenza A/Vietnam/1203/2004 (H5N1) and other heterosubtypic influenza A infections. Here, we used
Autor:
Nigel J. Waterhouse, Karin A Sedelies, Arno Müllbacher, Kylie A. Browne, Aulikki Koskinen, Vivien R. Sutton, Desiree A Anthony, Annette Ciccone, Joseph A. Trapani
Publikováno v:
The Journal of Cell Biology
Cathepsin C activates serine proteases expressed in hematopoietic cells by cleaving an N-terminal dipeptide from the proenzyme upon granule packaging. The lymphocytes of cathepsin C–null mice are therefore proposed to totally lack granzyme B activi