Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Augustus Kamassah"'
Autor:
Burgess Laurence E, Leyla Arik, Chester Chenguang Yuan, Nianhe Han, Randall W. Hungate, Derin C. D'amico, David A. Mareska, Feng-Yin Hsieh, Eileen Johnson, Hong Sun, Qingyian Liu, Barton H. Manning, Bobby Riahi, Christopher H. Fotsch, Gloria Biddlecome, Mark H. Norman, Augustus Kamassah, Ming Huang, Richard Loeloff, Gondi N. Kumar, Andras Toro, Jian J. Chen, Jason Brooks Human, Hideo Suzuki, Robert D. Groneberg, Benny C. Askew, Aiwen Li, Gordon Ng, James Zhan, Kaustav Biswas, Dianna Lester-Zeiner, Hong Dong, David E. Clarke
Publikováno v:
Journal of Medicinal Chemistry. 50:2200-2212
The bradykinin B1 receptor is induced following tissue injury and/or inflammation. Antagonists of this receptor have been studied as promising candidates for treatment of chronic pain. We have identified aryl sulfonamides containing a chiral chroman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb42b5aad05a1dc5bda8d29f83bc6dc6
https://doi.org/10.1021/jm070055c
https://doi.org/10.1021/jm070055c
Autor:
William A. Schmalhofer, Maria L. Garcia, Gregory J. Kaczorowski, Rosane Vianna-Jorge, Hans-Günther Knaus, Augustus Kamassah, Markus Hanner
Publikováno v:
Journal of Biological Chemistry. 273:16289-16296
Coexpression of α and β subunits of the high conductance Ca2+-activated K+(maxi-K) channel leads to a 50-fold increase in the affinity for125I-charybdotoxin (125I-ChTX) as compared with when the α subunit is expressed alone (Hanner, M., Schmalhofe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc94a55e19d92e04733eeac6e6422d7e
https://doi.org/10.1074/jbc.273.26.16289
https://doi.org/10.1074/jbc.273.26.16289
Autor:
Tanya Peterkin, Kaustav Biswas, Neil G. Andersen, Babak Riahi, Jian J. Chen, Gondi N. Kumar, Janan Jona, Kevin Yang, Judy Wang, Derin C. D'amico, Jason Brooks Human, Benny C. Askew, Thomas T. Nguyen, Qingyian Liu, Augustus Kamassah, Margaret M. Faul, Nobuko Nishimura, Christopher H. Fotsch, Wenyuan Qian, Eileen Johnson, Jiawang Zhu, Toshihiro Aya, Nianhe Han, Randall W. Hungate, John T. Colyer
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(11)
The discovery of novel and highly potent oxopiperazine based B1 receptor antagonists is described. Compared to the previously described arylsulfonylated (R)-3-amino-3-phenylpropionic acid series, the current compounds showed improved in vitro potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb9aeb3661b15590aeaea60c2a5a66d
https://pubmed.ncbi.nlm.nih.gov/21514825
https://pubmed.ncbi.nlm.nih.gov/21514825
Autor:
David A. Mareska, Dianna Lester-Zeiner, Randall W. Hungate, Eileen Johnson, Toshi Aya, Leyla Arik, Bobby Riahi, Mark H. Norman, Augustus Kamassah, Jian J. Chen, Gloria Biddlecome, Judy Wang, Christopher H. Fotsch, Paul J. Reider, Jason Brooks Human, Benny C. Askew, Derin C. D'amico, Andras Toro, Burgess Laurence E, Carlo van Staden, Vellarkad N. Viswanadhan, Laird Ellen, Darren Martin Harvey, David E. Clarke, Gordon Ng, James Zhan, Kaustav Biswas, Christopher A. Willoughby, Hideo Suzuki, Robert D. Groneberg
Publikováno v:
Journal of medicinal chemistry. 50(4)
We report the discovery of chroman 28, a potent and selective antagonist of human, nonhuman primate, rat, and rabbit bradykinin B1 receptors (0.4-17 nM). At 90 mg/kg s.c., 28 decreased plasma extravasation in two rodent models of inflammation. A nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf3310fcb384164cb4574a4189d2825
https://pubmed.ncbi.nlm.nih.gov/17243660
https://pubmed.ncbi.nlm.nih.gov/17243660
A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core
Autor:
David A. Mareska, Eileen Johnson, Christopher H. Fotsch, Dianna Lester-Zeiner, Qingyian Liu, Gloria Biddlecome, Gordon Ng, James Zhan, Kaustav Biswas, Nianhe Bruce Han, Yueh-Ju Judy Wang, Joe Zhu, Babak Riahi, Gondi N. Kumar, Kevin Yang, Robert D. Groneberg, Derin C. D'amico, Feng-Yin Hsieh, Jian Jeff Chen, Benny C. Askew, Augustus Kamassah
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(8)
The bradykinin 1 (B1) receptor is upregulated during times of inflammation and is important for maintaining inflamed and chronic pain states. Blocking this receptor has been shown to reverse and/or ameliorate pain and inflammation in animal models. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5310f114bdf0cdb04629d50164f8f659
https://pubmed.ncbi.nlm.nih.gov/16464576
https://pubmed.ncbi.nlm.nih.gov/16464576
Autor:
Wei Zhongyong, Fei Zhou, Stephane St-Onge, Daniel Delorme, Pierre-Emmanuel Morin, Ralf Schmidt, Christopher Walpole, Maryse Labarre, Julie Ducharme, Benjamin Pelcman, Denis Projean, Kemal Payza, Shi Yi Yue, Helene Gagnon, Hua Yang, William Brown, Lars Gawell, Augustus Kamassah, Edward Roberts, Edward Zhou, Niklas Plobeck, Peter Schwarz
Publikováno v:
Journal of medicinal chemistry. 43(21)
Nonpeptide delta opioid agonists are analgesics with a potentially improved side-effect and abuse liability profile, compared to classical opioids. Andrews analysis of the NIH nonpeptide lead SNC-80 suggested the removal of substituents not predicted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9712a1e21e6971a34a29440bf30ca9be
https://pubmed.ncbi.nlm.nih.gov/11052793
https://pubmed.ncbi.nlm.nih.gov/11052793
Autor:
William Brown, Claude Godbout, Denis Projean, Bryan K. Takasaki, Ralf Schmidt, Joanne Butterworth, Wei Zhongyong, Helene Gagnon, Lars Gawell, Pierre-Emmanuel Morin, Chris Walpole, Daniel Delorme, Hua Yang, Julie Ducharme, Edward Roberts, Paul Jones, Maryse Labarre, Shi-Yi Yue, Andrea Jakob, Augustus Kamassah, Kemal Payza, Niklas Plobeck, Fei Zhou, Stephane St-Onge
Publikováno v:
Journal of medicinal chemistry. 43(21)
The design, synthesis, and pharmacological evaluation of a novel class of delta opioid receptor agonists, N, N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide (6a) and its analogues, are described. These compounds, formally derived from SNC-80 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409968a355db6a0a17b98e4365474fab
https://pubmed.ncbi.nlm.nih.gov/11052794
https://pubmed.ncbi.nlm.nih.gov/11052794
Publikováno v:
The Journal of General Physiology
Dehydrosoyasaponin-I (DHS-I) is a potent activator of high-conductance, calcium-activated potassium (maxi-K) channels. Interaction of DHS-I with maxi-K channels from bovine aortic smooth muscle was studied after incorporating single channels into pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4df5285d59cb7453ba9e7d0cd4541ce
https://pubmed.ncbi.nlm.nih.gov/9758866
https://pubmed.ncbi.nlm.nih.gov/9758866
Autor:
Derin C. D'Amico, Toshi Aya, Jason Human, Christopher Fotsch, Jian Jeffrey Chen, Kaustav Biswas, Bobby Riahi, Mark H. Norman, Christopher A. Willoughby, Randall Hungate, Paul J. Reider, Gloria Biddlecome, Dianna Lester-Zeiner, Carlo Van Staden, Eileen Johnson, Augustus Kamassah, Leyla Arik, Judy Wang, Vellarkad N. Viswanadhan, Robert D. Groneberg
Publikováno v:
Journal of Medicinal Chemistry; Feb2007, Vol. 50 Issue 4, p607-610, 4p