Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.

Autor: Augusto V Gonçalves, Shally R Margolis, Gustavo F S Quirino, Danielle P A Mascarenhas, Isabella Rauch, Randilea D Nichols, Eduard Ansaldo, Mary F Fontana, Russell E Vance, Dario S Zamboni

Publikováno v: PLoS Pathogens, Vol 15, Iss 6, p e1007886 (2019)

Inflammasomes are cytosolic multi-protein complexes that detect infection or cellular damage and activate the Caspase-1 (CASP1) protease. The NAIP5/NLRC4 inflammasome detects bacterial flagellin and is essential for resistance to the flagellated intr

Externí odkaz: https://doaj.org/article/59137ac06adb47fd85a53405d252b437

Sepsis-induced immunosuppression is marked by an expansion of a highly suppressive repertoire of FOXP3+ T-regulatory cells expressing TIGIT

Autor: Fernando Q. Cunha, Carlos W. S. Wanderley, Carlos Hiroji Hiroki, Camilla Meireles S Silva, Augusto V. Gonçalves, Gustavo Fernando da Silva Quirino, Guilherme Cesar Martelossi Cebinelli, Marcos Henrique Rosa, Thiago M. Cunha, Dario S. Zamboni, Jessica Adrielle Teixeira Santos, José-Carlos A Filho, Mikhael Haruo Fernandes de Lima, Vanessa F. Borges

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background Although the literature shows that an increase in both the number and suppressive function of CD4+forkhead box P3 (FOXP3)+ T-regulatory cells (Tregs) during sepsis contributes to an immunosuppressed state, little is known about the identit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003a7d4437cf84e89e63682a8fd123f0

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Autor: Eurico Arruda, Thiago M. Cunha, Letícia Pastorelli Bonjorno, Dario S. Zamboni, Sérgio C. L. Almeida, Maria Auxiliadora-Martins, Maira N. Benatti, Tiana Kohlsdorf, Debora B. Perucello, Flávio P. Veras, Adriene Y. Ishimoto, Amanda Becerra, Alexandre Todorovic Fabro, Italo A. Castro, Diego B. Caetite, Rodrigo de Carvalho Santana, Sabrina Setembre Batah, Ricardo M. C. Castro, Fernando Crivelenti Vilar, Juliana E Toller-Kawahisa, Rodrigo Luppino-Assad, Letícia Yamawaka de Almeida, Larissa D. Cunha, Marjorie Cornejo Pontelli, Natalia B. do Amaral, Renê Donizeti Ribeiro de Oliveira, Warrison A. Andrade, José C. Alves-Filho, Tamara S Rodrigues, Fernando Q. Cunha, Li Siyuan, Maria Isabel Fernandes Lopes, Ronaldo B. Martins, Marcela C Giannini, Daniele C. Nascimento, Mikhael Haruo Fernandes de Lima, Camila Meirelles de Souza Silva, Fabiola Reis de Oliveira, Fabiani Gai Frantz, Keyla Santos Guedes de Sá, Augusto V. Gonçalves, Fábio Cury de Barros, Samuel L. Oliveira, Paulo Louzada-Junior

Publikováno v: Journal of Experimental Medicine
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The Journal of Experimental Medicine

This work shows that inflammasomes are activated in response to SARS-CoV-2 infection in vitro and in COVID-19 patients. Activation of inflammasomes in moderate and severe cases of COVID-19 contributes to the exacerbated inflammatory response, impacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f277baa80819f0a89da2dba05a33911
https://doi.org/10.1084/jem.20201707