Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Augusto Manubens"'
Autor:
Diego A. Díaz-Dinamarca, Michelle L. Salazar, Daniel F. Escobar, Byron N. Castillo, Bastián Valdebenito, Pablo Díaz, Augusto Manubens, Fabián Salazar, Mayarling F. Troncoso, Sergio Lavandero, Janepsy Díaz, María Inés Becker, Abel E. Vásquez
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The development of vaccine adjuvants is of interest for the management of chronic diseases, cancer, and future pandemics. Therefore, the role of Toll-like receptors (TLRs) in the effects of vaccine adjuvants has been investigated. TLR4 ligand-based a
Externí odkaz:
https://doaj.org/article/fe040994137a4fb786bc7c6c6b76ff8d
Autor:
Diego A. Díaz-Dinamarca, Michelle L. Salazar, Byron N. Castillo, Augusto Manubens, Abel E. Vasquez, Fabián Salazar, María Inés Becker
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1671 (2022)
New-generation vaccines, formulated with subunits or nucleic acids, are less immunogenic than classical vaccines formulated with live-attenuated or inactivated pathogens. This difference has led to an intensified search for additional potent vaccine
Externí odkaz:
https://doaj.org/article/a79ffd4ac05b43c49d295b339fb52ba5
Autor:
José M. Jiménez, Michelle L. Salazar, Sergio Arancibia, Javiera Villar, Fabián Salazar, Gordon D. Brown, Ed C. Lavelle, Luisa Martínez-Pomares, Jafet Ortiz-Quintero, Sergio Lavandero, Augusto Manubens, María Inés Becker
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) and driving immune response
Externí odkaz:
https://doaj.org/article/09a1af432b354c879d5b0d1dee5c709b
Autor:
Juan José Mora Román, Miguel Del Campo, Javiera Villar, Francesca Paolini, Gianfranca Curzio, Aldo Venuti, Lilian Jara, Jorge Ferreira, Paola Murgas, Alvaro Lladser, Augusto Manubens, María Inés Becker
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as carriers/adjuvants of tumor-associated
Externí odkaz:
https://doaj.org/article/ebf5bd48278b445bbdea1c847ec62564
Autor:
Sergio Arancibia, Cecilia Espinoza, Fabián Salazar, Miguel Del Campo, Ricardo Tampe, Ta-Ying Zhong, Pablo De Ioannes, Bruno Moltedo, Jorge Ferreira, Ed C Lavelle, Augusto Manubens, Alfredo E De Ioannes, María Inés Becker
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87240 (2014)
Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as immunomodulatory proteins with proven anti-cancer properties. The biodiversity of hemocyanins has promoted interest in identifying new anti-cancer candidates with i
Externí odkaz:
https://doaj.org/article/c4f42fe7354f46b280f1bbded6b511fb
Autor:
Maira Rivera, Javiera Villar, Mauricio Baez, José M. Jiménez, Michelle L. Salazar, María Inés Becker, Augusto Manubens
Publikováno v:
The Journal of Biological Chemistry
Hemocyanins are widely used as carriers, adjuvants, and nonspecific immunostimulants in cancer because they promote Th1 immunity in mammals. Hemocyanins also interact with glycan-recognizing innate immune receptors on antigen-presenting cells, such a
Autor:
Gianfranca Curzio, Lilian Jara, Javiera Villar, Augusto Manubens, Aldo Venuti, María Inés Becker, Alvaro Lladser, Juan José Mora Román, Paola Murgas, Miguel Del Campo, Francesca Paolini, Jorge Ferreira
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
Journal of Immunology Research
Journal of Immunology Research
Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as carriers/adjuvants of tumor-associated
Autor:
María Inés Becker, Michelle L Salazar, Diego Díaz-Dinamarca, Abel E Vásquez, Javiera Villar, Alejandra Alvarado, Byron Castillo, Daniel Navarro, Fabián Salazar, Augusto Manubens
Publikováno v:
The Journal of Immunology. 208:102.26-102.26
Hemocyanins are oligomeric glycoproteins widely used as immunomodulators because they bias immunity towards a Th1 profile when inoculated in mammals. We have demonstrated that hemocyanins are internalized through receptor-mediated endocytosis, and TL
Autor:
Miguel Del Campo, Flavio Salazar-Onfray, Michelle L. Salazar, Javiera Villar, Mohammad Y. Alshahrani, Daniel A. Mitchell, Ignacio Ávalos, José M. Jiménez, Fabián Salazar, María Alejandra Gleisner, Augusto Manubens, Luisa Martinez-Pomares, María Inés Becker
Publikováno v:
European journal of immunologyReferences. 51(7)
Hemocyanins are used as immunomodulators in clinical applications because they induce a strong Th1-biased cell-mediated immunity, which has beneficial effects. They are multiligand glycosylated molecules with abundant and complex mannose-rich structu
Autor:
María Inés Becker, Andrea González, Alfredo E. De Ioannes, Esteban Nova, Augusto Manubens, Miguel Del Campo, Jorge Ferreira
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1865(12)
Hemocyanins have highly conserved copper-containing active sites that bind oxygen. However, structural differences among the hemocyanins of various mollusks may affect their physicochemical properties. Here, we studied the oxygen-binding cooperativit