The Isolation of New Pore-Forming Toxins from the Sea Anemone Actinia fragacea Provides Insights into the Mechanisms of Actinoporin Evolution

Autor: Koldo Morante, Augusto Bellomio, Ana Rosa Viguera, Juan Manuel González-Mañas, Kouhei Tsumoto, Jose M. M. Caaveiro

Publikováno v: Toxins, Vol 11, Iss 7, p 401 (2019)

Random mutations and selective pressure drive protein adaptation to the changing demands of the environment. As a consequence, nature favors the evolution of protein diversity. A group of proteins subject to exceptional environmental stress and known

Externí odkaz: https://doaj.org/article/f1c44771913946f1a4b329d3891bea35

Pediocin-like bacteriocins: new perspectives on mechanism of action and immunity

Autor: Augusto Bellomio, Natalia Soledad Ríos Colombo, Silvia Adriana Navarro, Miriam Carolina Chalon

Publikováno v: Current Genetics. 64:345-351

This review attempts to analyze the mechanism of action and immunity of class IIa bacteriocins. These peptides are promising alternative food preservatives and they have a great potential application in medical sciences. Class IIa bacteriocins act on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e03ec8b9db8169c543d2c299d8eedda
https://doi.org/10.1007/s00294-017-0757-9

Obtaining an Ent35-MccV derivative with mutated hinge region that exhibits increased activity against listeria monocytogenes and escherichia coli

Autor: N. S. Ríos Colombo, Miriam Carolina Chalon, Leonardo Acuña, Silvia Adriana Navarro, M. Fernandez de Ullivarri, L. Lanza, Augusto Bellomio, B. Sosa-Padilla, Gianluca Picariello

Publikováno v: Applied microbiology and biotechnology 103 (2019): 9607–9618. doi:10.1007/s00253-019-10187-5
info:cnr-pdr/source/autori:Navarro S.A.; Lanza L.; Colombo N.S.R.; de Ullivarri M.F.; Acuna L.; Sosa-Padilla B.; Picariello G.; Bellomio A.; Chalon M.C./titolo:Obtaining an Ent35-MccV derivative with mutated hinge region that exhibits increased activity against Listeria monocytogenes and Escherichia coli/doi:10.1007%2Fs00253-019-10187-5/rivista:Applied microbiology and biotechnology/anno:2019/pagina_da:9607/pagina_a:9618/intervallo_pagine:9607–9618/volume:103

The present paper describes the generation of derivatives from the hybrid peptide called Ent35-MccV, active against Gram-positive and Gram-negative bacteria. This peptide has a triple glycine hinge region between enterocin CRL35 and microcin V. In or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc4199fcc3ba4943c13abe2db35d76d
https://link.springer.com/article/10.1007/s00253-019-10187-5

The case for class II bacteriocins: A biophysical approach using 'suicide probes' in receptor-free hosts to study their mechanism of action

Autor: F.G. Dupuy, N. S. Ríos Colombo, Augusto Bellomio, Miriam Carolina Chalon, Claudio F. Gonzalez

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Class II bacteriocins are unmodified membrane-active peptides that act over a narrow spectrum of target bacteria. They bind a specific receptor protein on the membrane to form a pore, leading to membrane permeabilization and cell death. However, litt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ffbf4995dff008ce5da3d2a74702e8
https://www.sciencedirect.com/science/article/pii/S030090841930224X

Identification of a Membrane-bound Prepore Species Clarifies the Lytic Mechanism of Actinoporins * ♦

Autor: Juan Manuel González-Mañas, Mikel Valle, Augusto Bellomio, Kouhei Tsumoto, David Gil-Carton, Koldo Morante, Jose M. M. Caaveiro, Jesús Sot, Simon Scheuring, Lorena Redondo-Morata

Publikováno v: The Journal of Biological Chemistry
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, ⟨10.1074/jbc.M116.734053⟩

Pore-forming toxins (PFTs) are cytolytic proteins belonging to the molecular warfare apparatus of living organisms. The assembly of the functional transmembrane pore requires several intermediate steps ranging from a water-soluble monomeric species t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2c1c22794f4eba105b0dc6e8bc79cc
http://europepmc.org/articles/PMC5016661