Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Augustinus H. M. Smelt"'
Autor:
Augustinus H. M. Smelt, F. de Beer
Publikováno v:
Seminars in Vascular Medicine. 4:249-257
In humans, apolipoprotein E (apoE) is a polymorphic protein of which three common isoforms can be distinguished, designated apoE2, apoE3, and apoE4. This genetic variation is associated with different plasma lipoprotein levels, different response to
Autor:
Arnoud van der Laarse, Iris J. A. M. Jonkers, Hiroaki Hattori, Teus van Gent, Augustinus H. M. Smelt, Frits H.A.F. de Man, L.M. Scheek, Arie van Tol
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 8, Pp 1462-1469 (2003)
Hypertriglyceridemia (HTG) is associated with insulin resistance, increased cholesteryl ester transfer (CET), and low HDL cholesterol. Phospholipid transfer protein (PLTP) may be involved in these relationships. Associations between CET, lipids, insu
Autor:
Arend E Meinders, A. van der Laarse, M.A van de Ree, Hans Jansen, Ilse Jonkers, Gerard J. Blauw, F.H.A.F. de Man, Augustinus H. M. Smelt
Publikováno v:
Cardiovascular Research. 53:496-501
Objectives: To infer the relative impact of elevated triglyceride levels and insulin resistance on endothelial dysfunction in patients with chronic hypertriglyceridemia (HTG). Methods: Endothelial function was studied in 11 HTG patients and 16 normol
Autor:
Augustinus H. M. Smelt, N. H. Van Tilburg, R M Bertina, Ilse Jonkers, Per Morten Sandset, A. van der Laarse, F.H.A.F. de Man
Publikováno v:
Blood Coagulation & Fibrinolysis. 12:705-712
Hypertriglyceridemia (HTG) is an independent risk factor for cardiovascular disease (CVD). Hemostatic variables [factor VII antigen (FVIIag), factor VII coagulant activity (FVIIc), activated factor VII (FVIIa), free and endothelial-associated (EC) ti
Publikováno v:
Atherosclerosis. 157:491-494
Patients with familial hypercholesterolemia (FH) are especially at risk for premature cardiovascular disease (CVD). Recent studies revealed C-reactive protein (CRP) as a strong predictor of future first or recurrent CVD events, suggesting that CRP pl
Autor:
Joep C. Defesche, John J.P. Kastelein, Rudi G. J. Westendorp, Augustinus H. M. Smelt, Eric J.G. Sijbrands, P.H.E.M. de Meier
Publikováno v:
BMJ. 322:1019-1023
Objective To estimate all cause mortality from untreated familial hypercholesterolaemia free from selection for coronary artery disease. Design Family tree mortality study. Setting Large pedigree in Netherlands traced back to a single pair of ancesto
Autor:
Hans M.G. Princen, Wim van Duyvenvoorde, Jan A. Gevers Leuven, W. Onkenhout, Augustinus H. M. Smelt, Edzard Schwedhelm, Raphael Troost, Arnoud van der Laarse, Frits H.A.F. de Man, R. Buytenhek, Iris J. A. M. Jonkers
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 20:2434-2440
Abstract —Although there is evidence that hyperlipidemia and predominance of small dense low density lipoproteins (LDLs) are associated with increased oxidative stress, the oxidation status in patients with hypertriglyceridemia (HTG) has not been s
Autor:
Jan A. Gevers Leuven, Rienk Nieuwland, Fred P.H.T.M. Romijn, Augustinus H. M. Smelt, Frits H de Man, Augueste Sturk, Arnoud van der Laarse
Publikováno v:
Atherosclerosis. 152:407-414
Hypertriglyceridemia, a risk factor for cardiovascular disease, has been associated with hypercoagulability, but whether platelet activation is implicated is unknown. This study was designed to compare the in vivo platelet activation status between p
Autor:
Augustinus H. M. Smelt, Frits Jacobus Fallaux, Rob C. Hoeben, Louis M. Havekes, Miek C. Jong, Marten H. Hofker, L.C. van Vark, K.W. van Dijk, A. van der Zee, F. de Beer
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 20:1800-1806
Abstract —The apolipoprotein E2 (Lys146→Gln) variant is associated with a dominant form of familial dysbetalipoproteinemia. Heterozygous carriers of this variant have elevated levels of plasma triglycerides, cholesterol, and apolipoprotein E (apo
Autor:
Augustinus H. M. Smelt, F.H.A.F de Man, M.F Mohrschladt, R.G.J. Westendorp, Dirk-Jan Stoeken, Annelies W. E. Weverling-Rijnsburger, Augueste Sturk
Publikováno v:
Atherosclerosis. 148:413-419
Low-density lipoprotein (LDL)-receptor deficient mice, thus hypercholesterolemic, combine protection against infection with an ex vivo two- to threefold higher pro-inflammatory cytokine production in macrophages. A pro-inflammatory cytokine profile e