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pro vyhledávání: '"Augustine Ochen"'
Autor:
Fiona Slater, Katie Ruffell, Helen E. Aylott, Robert Whitten, Augustine Ochen, Janelle E. Steves, Mahesh J. Sanganee, Glynn D. Williams, Paul G. Evans, Andrew S. Roberts
Publikováno v:
Organometallics. 38:176-184
An improved process to an aldehyde en route to an LSD1 inhibitor was developed using an aerobic oxidation with a CuI and TEMPO (2,2,6,6-tetramethylpiperdine 1-oxyl) catalyst system. In this report, kinetic information is utilized to understand the ge
Autor:
Erica Vit, Jerome F. Hayes, Francois-Rene Alexandre, Cyril B. Dousson, Christophe Claude Parsy, David D. Pascoe, Catherine Caillet, Marie-Pierre Lioure, Neil Hodnett, Elodie Rosinovsky, John Edward Richardson, Guillaume Bret, Stéphanie Bot, Agnès Amador, Gary T. Borrett, Bernadette Choudary, Arlène Roland, Daniel Da Costa, Alan Ironmonger, John D. Hayler, Augustine Ochen, Séverine Bonaric, David Colclough, Richard K. Bellingham
Publikováno v:
Organic Process Research & Development. 22:200-206
A new and improved synthetic route to an intermediate in the synthesis of the phosphinate ester GSK2248761A is described. In the key step, we describe the first process-scale example of a palladium-catalyzed phosphorus–carbon coupling to give the e