Inflammatory and glycolytic programs underpin a primed blood neutrophil state in patients with pneumonia

Autor: Alex R. Schuurman, Joe M. Butler, Erik H.A. Michels, Natasja A. Otto, Xanthe Brands, Bastiaan W. Haak, Fabrice Uhel, Augustijn M. Klarenbeek, Daniël R. Faber, Bauke V. Schomakers, Michel van Weeghel, Alex F. de Vos, Brendon P. Scicluna, Riekelt H. Houtkooper, W. Joost Wiersinga, Tom van der Poll

Publikováno v: iScience, Vol 26, Iss 7, Pp 107181- (2023)

Summary: Neutrophils are potent immune cells with key antimicrobial functions. Previous in vitro work has shown that neutrophil effector functions are mainly fueled by intracellular glycolysis. Little is known about the state of neutrophils still in

Externí odkaz: https://doaj.org/article/4e949718e4164c9fb99adf50b5dffd0d

Rectal microbiota are coupled with altered cytokine production capacity following community-acquired pneumonia hospitalization

Autor: Robert F.J. Kullberg, Xanthe Brands, Augustijn M. Klarenbeek, Joe M. Butler, Natasja A. Otto, Daniël R. Faber, Brendon P. Scicluna, Tom van der Poll, W. Joost Wiersinga, Bastiaan W. Haak

Publikováno v: iScience, Vol 25, Iss 8, Pp 104740- (2022)

Summary: Human studies describing the immunomodulatory role of the intestinal microbiota in systemic infections are lacking. Here, we sought to relate microbiota profiles from 115 patients with community-acquired pneumonia (CAP), both on hospital adm

Externí odkaz: https://doaj.org/article/66433c03a1ff48519f96542990b54e96

Corrigendum: Concurrent Immune Suppression and Hyperinflammation in Patients With Community-Acquired Pneumonia

Autor: Xanthe Brands, Bastiaan W. Haak, Augustijn M. Klarenbeek, Natasja A. Otto, Daniël R. Faber, René Lutter, Brendon P. Scicluna, W. Joost Wiersinga, Tom van der Poll

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Externí odkaz: https://doaj.org/article/be43d72b84be4a4796a245a1618bff3d

Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death

Autor: Agtmael, Michiel van, Algera, Anne Geke, Appelman, Brent, van Baarle, Floor, Beudel, Martijn, Bogaard, Harm Jan, Bomers, Marije, Bonta, Peter, Bos, Lieuwe, Botta, Michela, de Brabander, Justin, de Bree, Godelieve, de Bruin, Sanne, Bugiani, Marianna, Bulle, Esther, Buis, David T.P., Chouchane, Osoul, Clohert, Alex, Dijkstra, Mirjam, Dongelmans, Dave A., Dujardin, Romein W.G., Elbers, Paul, Fleuren, Lucas, Geerlings, Suzanne, Geijtenbeek, Theo, Girbes, Armand, Goorhuis, Bram, Grobusch, Martin P., Hagens, Laura, Hamann, Jorg, Harris, Vanessa, Hemke, Robert, Hermans, Sabine M., Heunks, Leo, Hollmann, Markus, Horn, Janneke, Hovius, Joppe W., de Jong, Menno D., Koning, Rutger, Lim, Endry H.T., van Mourik, Niels, Nellen, Jeaninne, Nossent, Esther J., Olie, Sabine, Paulus, Frederique, Peters, Edgar, Pina-Fuentes, Dan A.I., van der Poll, Tom, Preckel, Bennedikt, Raasveld, Jorinde, Reijnders, Tom, de Rotte, Maurits C.F.J., Schinkel, Michiel, Schultz, Marcus J., Schrauwen, Femke A.P., Schuurman, Alex, Schuurmans, Jaap, Sigaloff, Kim, Slim, Marleen A., Smeele, Patrick, Smit, Marry, Stijnis, Cornelis S., Stilma, Willemke, Teunissen, Charlotte, Thoral, Patrick, Tsonas, Anissa M., Tuinman, Pieter R., van der Valk, Marc, Veelo, Denise, Volleman, Carolien, de Vries, Heder, Vught, Lonneke A., van Vugt, Michèle, Wouters, Dorien, Zwinderman, A.H., Brouwer, Matthijs C., Wiersinga, W. Joost, Vlaar, Alexander P.J., van de Beek, Diederik, Léopold, Valentine, Butler, Joe M., Schuurman, Alex R., Michels, Erik H.A., Schomakers, Bauke V., van Weeghel, Michel, Picavet-Havik, Daisy I., Grootemaat, Anita E., Douma, Renée A., Reijnders, Tom D.Y., Klarenbeek, Augustijn M., van der Wel, Nicole N., den Dunnen, Jeroen, Houtkooper, Riekelt H., van't Veer, Cornelis

Publikováno v: In Research and Practice in Thrombosis and Haemostasis October 2023 7(7)

Inflammatory and glycolytic programs underpin a primed blood neutrophil state in patients with pneumonia

Autor: Schuurman, Alex R., Butler, Joe M., Michels, Erik H.A., Otto, Natasja A., Brands, Xanthe, Haak, Bastiaan W., Uhel, Fabrice, Klarenbeek, Augustijn M., Faber, Daniël R., Schomakers, Bauke V., van Weeghel, Michel, de Vos, Alex F., Scicluna, Brendon P., Houtkooper, Riekelt H., Wiersinga, W. Joost, van der Poll, Tom

Publikováno v: In iScience 21 July 2023 26(7)