Zobrazeno 1 - 4
of 4
pro vyhledávání: '"August Buchhalter"'
Autor:
Megan J. Shram, Jack E. Henningfield, Glen Apseloff, Charles W. Gorodetzky, Sara De Martin, Frank L. Vocci, Frank L. Sapienza, Thomas R. Kosten, Jeff Huston, August Buchhalter, Judy Ashworth, Ryan Lanier, Franco Folli, Andrea Mattarei, Clotilde Guidetti, Stefano Comai, Cedric O’Gorman, Sergio Traversa, Charles E. Inturrisi, Paolo L. Manfredi, Marco Pappagallo
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2, randomized, double-blind, placebo-controlled trial, esmethadone showed rapid, robu
Externí odkaz:
https://doaj.org/article/b958bfa2946e4409a7e15362350d0462
Autor:
Jack Henningfield, David Gauvin, Francesco Bifari, Reginald Fant, Megan Shram, August Buchhalter, Judy Ashworth, Ryan Lanier, Marco Pappagallo, Charles Inturrisi, Franco Folli, Sergio Traversa, Paolo L. Manfredi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract REL-1017 (esmethadone, d-methadone) is the opioid-inactive d-isomer of racemic d,l-methadone. REL-1017 may exert antidepressant effects via uncompetitive N-methyl-d-aspartate receptor (NMDAR) channel block. As REL-1017 is expected to exert c
Externí odkaz:
https://doaj.org/article/af8fabe8ee0d48f4ab00370a37dd858f
Autor:
Jack Henningfield, David Gauvin, Francesco Bifari, Reginald Fant, Megan Shram, August Buchhalter, Judy Ashworth, Ryan Lanier, Marco Pappagallo, Charles Inturrisi, Franco Folli, Sergio Traversa, Paolo L. Manfredi
Publikováno v:
Scientific reports. 12(1)
REL-1017 (esmethadone, d-methadone) is the opioid-inactive d-isomer of racemic d,l-methadone. REL-1017 may exert antidepressant effects via uncompetitive N-methyl-d-aspartate receptor (NMDAR) channel block. As REL-1017 is expected to exert central ne
Conference
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