Výsledky vyhledávání - "Augie Machado"

Supercritical-CO2 Foam Extrusion of Hydroxypropyl Methyl Cellulose Acetate Succinate/Itraconazole Amorphous Solid Dispersions: Processing-Structure-Property Relations

Autor: Augie Machado, Brian Haight, Fan Meng, Feng Zhang, Shahab Kashani Rahimi, Charlie Martin, Tony Listro, Kevin E. O'Donnell

Publikováno v: Journal of Pharmaceutical Sciences. 110:1444-1456

This study investigates the effects of supercritical CO2 as a foaming agent on structure and physical properties of hot melt extruded hydroxypropyl methylcellulose acetate succinate (HPMCAS)-itraconazole (ITZ) amorphous solid dispersions (ASDs) with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd6d3566f8b5fa009294c058d1856e8e
https://doi.org/10.1016/j.xphs.2020.11.038

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Supercritical-CO

Autor: Shahab Kashani, Rahimi, Kevin, O'Donnell, Brian, Haight, Augie, Machado, Charlie, Martin, Fan, Meng, Tony, Listro, Feng, Zhang

Publikováno v: Journal of pharmaceutical sciences. 110(4)

This study investigates the effects of supercritical CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ab7c0217bfebb3cdac8e24665de494b
https://pubmed.ncbi.nlm.nih.gov/33285183

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Scale-Up and In-line Monitoring During Continuous Melt Extrusion of an Amorphous Solid Dispersion

Autor: Brian Haight, Augie Machado, Abbe Haser, Andreas Berghaus, Charlie Martin, Feng Zhang

Publikováno v: AAPS PharmSciTech

Chemical degradation of drug substances remains a major drawback of extrusion. Larger-scale extrusion equipment has advantages over smaller equipment due to deeper flight elements and added flexibility in terms of screw design, unit operations, and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2aebb562ffb6a7ab7bdc74a7f60367
https://doi.org/10.1208/s12249-018-1162-5

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Investigation of process temperature and screw speed on properties of a pharmaceutical solid dispersion using corotating and counter-rotating twin-screw extruders

Autor: Augie Machado, Justin M. Keen, Harpreet K. Sandhu, James DiNunzio, James W. McGinity, Charlie Martin

Publikováno v: The Journal of pharmacy and pharmacology. 66(2)

Objective The use of corotating twin screw hot-melt extruders to prepare amorphous drug/polymer systems has become commonplace. As small molecule drug candidates exiting discovery pipelines trend towards higher MW and become more structurally complic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edd485a5793f48b4b9578794c747651
https://pubmed.ncbi.nlm.nih.gov/24433423

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