Carotid body: an emerging target for cardiometabolic co‐morbidities

Autor: Pratik Thakkar, Audrys G. Pauza, David Murphy, Julian F. R. Paton

Publikováno v: Experimental Physiology, Vol 108, Iss 5, Pp 661-671 (2023)

Abstract The maintenance of glucose homeostasis is obligatory for health and survival. It relies on peripheral glucose sensing and signalling between the brain and peripheral organs via hormonal and neural responses that restore euglycaemia. Failure

Externí odkaz: https://doaj.org/article/509894924c1846baaa3d9750d0bbd56d

Cellular basis of learning and memory in the carotid body

Autor: Olivia M. S. Gold, Emma N. Bardsley, Anna P. Ponnampalam, Audrys G. Pauza, Julian F. R. Paton

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 14 (2022)

The carotid body is the primary peripheral chemoreceptor in the body, and critical for respiration and cardiovascular adjustments during hypoxia. Yet considerable evidence now implicates the carotid body as a multimodal sensor, mediating the chemoref

Externí odkaz: https://doaj.org/article/a35802775aa34334ab0e7038d68b2044

In the balance: how do thrombospondins contribute to the cellular pathophysiology of cardiovascular disease?

Autor: Tessa Forbes, Josephine C. Adams, Audrys G Pauza

Publikováno v: American Journal of Physiology-Cell Physiology. 321:C826-C845

Thrombospondins (TSPs) are multidomain, secreted proteins that associate with cell surfaces and extracellular matrix. In mammals, there is a large body of data on functional roles of various TSP family members in cardiovascular disease (CVD), includi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27a21af11fcfdd5bd22253cda50bb3a
https://doi.org/10.1152/ajpcell.00251.2021

Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model

Autor: Paolo Contessotto, Renza Spelat, Vaidas Vysockas, Aušra Krivickienė, Chunsheng Jin, Sandrine Chantepie, Clizia Chinello, Audrys G. Pauza, Mindaugas Rackauskas, Vilma Zigmantaitė, Fulvio Magni, Dulce Papy-Garcia, Niclas G. Karlsson, Eglė Ereminienė, Abhay Pandit, Mark Da Costa

The rising incidence of non-ST-segment elevation myocardial infarction (NSTEMI) and associated long-term high mortality constitutes an urgent clinical issue. Unfortunately, the study of possible interventions to treat this pathology lacks a reproduci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3deb611f2d4a7e5113f2b2b66eb82ce4
https://doi.org/10.1101/2022.05.19.492645

Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver

Autor: Matthew T. Birnie, Alex Paterson, Diana A. Stavreva, YM Kershaw, Becky L. Conway-Campbell, Audrys G Pauza, Songjoon Baek, David Murphy, Mark F. Rogers, Benjamin P. Flynn, Sohyoung Kim, Gordon L. Hager, Stafford L. Lightman

Publikováno v: PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics

Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ed6b521145c837c00c33b28a1f80b1
https://doaj.org/article/ebb7253002144d5885d6bce3701f46a0