Výsledky vyhledávání - "Audronė, Marozienė"

Aerobic cytotoxicity of aromatic N-oxides: the role of NAD(P)H:quinone oxidoreductase (NQO1)

Autor: Audronė Marozienė, Mindaugas Lesanavičius, Aušra Nemeikaitė-Čėnienė, Jonas Šarlauskas, Violeta Jonušienė, Narimantas Čėnas, Lina Misevičienė

Publikováno v: International journal of molecular sciences, Basel : MDPI, 2020, vol. 21, iss. 22, art. no. 8754, p. [1-13]
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8754, p 8754 (2020)

Derivatives of tirapazamine and other heteroaromatic N-oxides (ArN&rarr
O) exhibit tumoricidal, antibacterial, and antiprotozoal activities, which are typically attributed to bioreductive activation and free radical generation. In this work, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81792b1b6d53491a269befb96c01c73b
https://repository.vu.lt/VU:ELABAPDB80478955&prefLang=en_US

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Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase

Autor: Audronė Marozienė, Jonas Šarlauskas, Mindaugas Lesanavičius, Narimantas Čėnas, Philippe Grellier, Alessandro Aliverti, Elisabeth Davioud-Charvet

Publikováno v: Molecules
Molecules, MDPI, 2019, 24 (24), pp.4509. ⟨10.3390/molecules24244509⟩
Molecules, Basel : MDPI, 2019, vol. 24, no. 24, art. no. 4509, p. [1-15]
Volume 24
Issue 24

International audience; With the aim to clarify the mechanism(s) of action of nitroaromatic compounds against the malaria parasite Plasmodium falciparum, we examined the single-electron reduction by P. falciparum ferredoxin:NADP + oxidoreductase (Pf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e18079c97f598a0daa0dcde1c273e16
https://hal-mnhn.archives-ouvertes.fr/mnhn-02867389

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Kinetics of flavoenzyme-catalyzed reduction of tirapazamine derivatives: implications for their prooxidant cytotoxicity

Autor: Narimantas Čėnas, Violeta Jonušienė, Lina Misevičienė, A. V. Yantsevich, Aušra Nemeikaitė-Čėnienė, Audronė Marozienė, Jonas Šarlauskas

Publikováno v: International journal of molecular sciences: Special issue: Bioreductive activation/detoxification of prooxidant xenobiotics and drugs, Basel : MDPI, 2019, vol. 20, no. 18, p. 4602-4616
International Journal of Molecular Sciences
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4602 (2019)

Derivatives of tirapazamine and other heteroaromatic N-oxides (ArN&rarr
O) exhibit promising antibacterial, antiprotozoal, and tumoricidal activities. Their action is typically attributed to bioreductive activation and free radical generation. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea22ff7141a2128b1d6ed5cb463bad9
https://repository.vu.lt/VU:ELABAPDB49008306&prefLang=en_US

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Enzymatic single-electron reduction and aerobic cytotoxicity of tirapazamine and its 1-oxide and nor-oxide metabolites

Autor: Aušra Nemeikaitė-Čėnienė, Jonas Šarlauskas, Audronė Marozienė, Narimantas Čėnas, Lina Misevičienė, Mindaugas Lesanavičius

Publikováno v: Chemija. 29

Aerobic cytotoxicity of 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ), a bioreductively activated hypoxia-specific anticancer agent, is responsible for TPZ side effects in chemotherapy. In order to clarify its mechanisms, we examined th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::214cf1b3131929feeb0da74d59ce87b8
https://doi.org/10.6001/chemija.v29i4.3843

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Quinones and nitroaromatic compounds as subversive substrates of Staphylococcus aureus flavohemoglobin

Autor: Florence Lederer, Laura Baciou, Narimantas Čėnas, Audronė Marozienė, Myriam Moussaoui, Žilvinas Anusevičius, Lina Misevičienė

Publikováno v: Free Radical Biology and Medicine
Free Radical Biology and Medicine, Elsevier, 2018, 123, pp.107-115. ⟨10.1016/j.freeradbiomed.2018.05.071⟩

In microorganisms, flavohemoglobins (FHbs) containing FAD and heme (Fe3+, metHb) convert NO. into nitrate at the expense of NADH and O2. FHbs contribute to bacterial resistance to nitrosative stress. Therefore, inhibition of FHbs functions may decrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890d0271819669beb408efa9c3222d2d
https://hal.archives-ouvertes.fr/hal-02368450

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Naphtho[1',2':4,5]imidazo[1,2-a]pyridine-5,6-diones: Synthesis, enzymatic reduction and cytotoxic activity

Autor: Žilvinas Anusevičius, Jonas Šarlauskas, Milda Pečiukaitytė-Alksnė, Audronė Marozienė, Evelina Polmickaitė, Narimantas Čėnas, Zita Staniulytė, Lina Misevičienė

Publikováno v: Bioorganicmedicinal chemistry letters. 26(2)

Naphtho[1',2':4,5]imidazo[1,2-a]pyridine-5,6-diones (NPDOs), a new type of N-heterocycle-fused o-quinones, have been synthesized. They have been found to be efficient electron-accepting substrates of NADPH-dependent single-electron-transferring P-450

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0462086b3ddbf2a9bdca051bd967ef13
https://pubmed.ncbi.nlm.nih.gov/26681508

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The study of NADPH-dependent flavoenzyme-catalyzed reduction of benzo[1,2-c]1,2,5-oxadiazole N-oxides (benzofuroxans)

Autor: Lina Misevičienė, Narimantas Čėnas, Aleksey Yantsevich, Audrius Laurynėnas, Laimonas Karvelis, Kastis Krikštopaitis, Audronė Marozienė, Jonas Šarlauskas, Žilvinas Anusevičius, Jonita Stankevičiūtė

Publikováno v: International Journal of Molecular Sciences
Volume 15
Issue 12
Pages 23307-23331
International journal of molecular sciences, Basel : MDPI AG, 2014, Vol. 15, iss. 12, p. 23307-23331
International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 23307-23331 (2014)

The enzymatic reactivity of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxides (benzofuroxans
BFXs) towards mammalian single-electron transferring NADPH:cytochrome P-450 reductase (P-450R) and two-electron (hydride) transferring NAD(P)H:quinone o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec30be4f3821b86865d6db9e58fcd1c
https://pubmed.ncbi.nlm.nih.gov/25517035

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