Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Audrey van Drogen"'
Autor:
Mattheus H. E. Wildschut, Julien Mena, Cyril Dördelmann, Marc van Oostrum, Benjamin D. Hale, Jens Settelmeier, Yasmin Festl, Veronika Lysenko, Patrick M. Schürch, Alexander Ring, Yannik Severin, Michael S. Bader, Patrick G. A. Pedrioli, Sandra Goetze, Audrey van Drogen, Stefan Balabanov, Radek C. Skoda, Massimo Lopes, Bernd Wollscheid, Alexandre P. A. Theocharides, Berend Snijder
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Myelofibrosis is a hematopoietic stem cell disorder belonging to the myeloproliferative neoplasms. Myelofibrosis patients frequently carry driver mutations in either JAK2 or Calreticulin (CALR) and have limited therapeutic options. Here, we
Externí odkaz:
https://doaj.org/article/be42116607d44feb831a5d12924ccd1b
Autor:
Martin Mehnert, Rodolfo Ciuffa, Fabian Frommelt, Federico Uliana, Audrey van Drogen, Kilian Ruminski, Matthias Gstaiger, Ruedi Aebersold
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Diseases can be associated with various mutations of the same gene, but the molecular consequences of specific mutations remain incompletely understood. Here, the authors present an integrated proteomic workflow to determine the molecular response of
Externí odkaz:
https://doaj.org/article/5284796b9f7e4306aca01803fd9b2199
Autor:
M. Teresa Bertran, Stéphane Mouilleron, Yanxiang Zhou, Rakhi Bajaj, Federico Uliana, Ganesan Senthil Kumar, Audrey van Drogen, Rebecca Lee, Jennifer J. Banerjee, Simon Hauri, Nicola O’Reilly, Matthias Gstaiger, Rebecca Page, Wolfgang Peti, Nicolas Tapon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Serine/threonine phosphatases such as PP1 associate with a large array of subunit proteins, such as ASPP (apoptosis-stimulating protein of p53) to achieve selective targeting. Here authors solved the crystal structure of the human ASPP2/PP1 complex a
Externí odkaz:
https://doaj.org/article/6895486193a040a6ada179998498e708
Autor:
Moritz Heusel, Isabell Bludau, George Rosenberger, Robin Hafen, Max Frank, Amir Banaei‐Esfahani, Audrey van Drogen, Ben C Collins, Matthias Gstaiger, Ruedi Aebersold
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 1, Pp 1-22 (2019)
Abstract Proteins are major effectors and regulators of biological processes that can elicit multiple functions depending on their interaction with other proteins. The organization of proteins into macromolecular complexes and their quantitative dist
Externí odkaz:
https://doaj.org/article/94f8741ead474fbc9b1bd932e6cc5d80
Autor:
Simon Hauri, Alexander Wepf, Audrey van Drogen, Markku Varjosalo, Nic Tapon, Ruedi Aebersold, Matthias Gstaiger
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-16 (2013)
Abstract Tissue homeostasis is controlled by signaling systems that coordinate cell proliferation, cell growth and cell shape upon changes in the cellular environment. Deregulation of these processes is associated with human cancer and can occur at m
Externí odkaz:
https://doaj.org/article/6309dc071d53472095ea29758789363f
Autor:
Markku Varjosalo, Salla Keskitalo, Audrey Van Drogen, Helka Nurkkala, Anton Vichalkovski, Ruedi Aebersold, Matthias Gstaiger
Publikováno v:
Cell Reports, Vol 3, Iss 4, Pp 1306-1320 (2013)
Cellular information processing via reversible protein phosphorylation requires tight control of the localization, activity, and substrate specificity of protein kinases, which to a large extent is accomplished by complex formation with other protein
Externí odkaz:
https://doaj.org/article/d5a6cc1589594c68803afea3942e7212
Autor:
Klara Kropivsek, Paul Kachel, Sandra Goetze, Rebekka Wegmann, Yasmin Festl, Yannik Severin, Benjamin D. Hale, Julien Mena, Audrey van Drogen, Nadja Dietliker, Joëlle Tchinda, Bernd Wollscheid, Markus G. Manz, Berend Snijder
Publikováno v:
Nature Cancer, 4 (5)
Multiple myeloma (MM) is a plasma cell malignancy defined by complex genetics and extensive patient heterogeneity. Despite a growing arsenal of approved therapies, MM remains incurable and in need of guidelines to identify effective personalized trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d1bfac614bd5927183f16d920704de
https://hdl.handle.net/20.500.11850/610901
https://hdl.handle.net/20.500.11850/610901
Autor:
Sohyon Lee, Tobias Weiss, Marcel Bühler, Julien Mena, Zuzanna Lottenbach, Rebekka Wegmann, Michel Bihl, Bartłomiej Augustynek, Sven Baumann, Sandra Goetze, Audrey van Drogen, Flavio Vasella, Elisabeth J. Rushing, Bernd Wollscheid, Matthias A. Hediger, Michael Weller, Berend Snijder
Glioblastoma is the most common yet deadliest primary brain cancer1. The neural behavior of glioblastoma, including the formation of synaptic circuitry and tumor microtubes, is increasingly understood to be pivotal for disease manifestation2–8. Non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05cb180820fd74ffa06b2c1b52e9050a
https://doi.org/10.1101/2022.10.07.511321
https://doi.org/10.1101/2022.10.07.511321
Autor:
Patrick Forny, Ximena Bonilla, David Lamparter, Wenguang Shao, Tanja Plessl, Caroline Frei, Anna Bingisser, Sandra Goetze, Audrey van Drogen, Keith Harshman, Patrick G. A. Pedrioli, Cedric Howald, Martin Poms, Florian Traversi, Sarah Cherkaoui, Raphael J. Morscher, Luke Simmons, Merima Forny, Ioannis Xenarios, Ruedi Aebersold, Nicola Zamboni, Gunnar Raetsch, Emmanouil Dermitzakis, Bernd Wollscheid, Matthias R. Baumgartner, D. Sean Froese
Multi-layered omics approaches can help define relationships between genetic factors, biochemical processes and phenotypes thus extending research of inherited diseases beyond identifying their monogenic cause 1. We implemented a multi-layered omics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c66a499557bdb72e7a6a318d421208
https://doi.org/10.1101/2022.01.27.22269972
https://doi.org/10.1101/2022.01.27.22269972
Autor:
Sohyon Lee, Tobias Weiss, Marcel Buehler, Rebekka Wegmann, Julien Mena, Michel Bihl, Sandra Goetze, Audrey van Drogen, Elisabeth Rushing, Bernd Wollscheid, Michael Weller, Berend Snijder
Publikováno v:
WFNOS 2022 Abstract Book.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e53b93cee009b5fcc0b2ddb0145b3e8f
https://doi.org/10.14791/btrt.2022.10.f-1178
https://doi.org/10.14791/btrt.2022.10.f-1178