Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

Autor: Camille Morel, Eline Lemerle, Feng-Ching Tsai, Thomas Obadia, Nishit Srivastava, Maud Marechal, Audrey Salles, Marvin Albert, Caroline Stefani, Yvonne Benito, François Vandenesch, Christophe Lamaze, Stéphane Vassilopoulos, Matthieu Piel, Patricia Bassereau, David Gonzalez-Rodriguez, Cecile Leduc, Emmanuel Lemichez

Publikováno v: eLife, Vol 12 (2024)

Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier. Recent advances in biophysical modeling point toward membrane tension and bending rigidi

Externí odkaz: https://doaj.org/article/28c0af341ffb43cfae9b133c85d5de56

CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence

Autor: Clément Crochemore, Cristina Fernández-Molina, Benjamin Montagne, Audrey Salles, Miria Ricchetti

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Senescence of metabolically active cells is a process linked to ageing. Here the authors reveal that CSB is required to block replicative senescence, and epigenetic control of CSB downregulation triggers proliferative arrest in a p21-dependent manner

Externí odkaz: https://doaj.org/article/7417a712e182448da3e35e34372714da

Dynamic Growth and Shrinkage of the Salmonella-Containing Vacuole Determines the Intracellular Pathogen Niche

Autor: Virginie Stévenin, Yuen-Yan Chang, Yoann Le Toquin, Magalie Duchateau, Quentin Giai Gianetto, Chak Hon Luk, Audrey Salles, Victoria Sohst, Mariette Matondo, Norbert Reiling, Jost Enninga

Publikováno v: Cell Reports, Vol 29, Iss 12, Pp 3958-3973.e7 (2019)

Summary: Salmonella is a human and animal pathogen that causes gastro-enteric diseases. The key to Salmonella infection is its entry into intestinal epithelial cells, where the bacterium resides within a Salmonella-containing vacuole (SCV). Salmonell

Externí odkaz: https://doaj.org/article/0924ec709bad47daa7fa77ffed1dacf6

Preferential transfer of certain plasma membrane proteins onto T and B cells by trogocytosis.

Autor: Sandrine Daubeuf, Anne Aucher, Christine Bordier, Audrey Salles, Laurent Serre, Gérald Gaibelet, Jean-Charles Faye, Gilles Favre, Etienne Joly, Denis Hudrisier

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8716 (2010)

T and B cells capture antigens via membrane fragments of antigen presenting cells (APC) in a process termed trogocytosis. Whether (and how) a preferential transfer of some APC components occurs during trogocytosis is still largely unknown. We analyze

Externí odkaz: https://doaj.org/article/03e2bbc560a048ac866148eb1e4c8ca4

The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis

Autor: Quentin Giai Gianetto, Neetu Gupta-Rossi, Mariette Matondo, Stéphane Frémont, Frédérique Cuvelier, Audrey Salles, Julia Chamot-Rooke, Hervé Ménager, Florine Milin, Sandrine Schmutz, Cyril Addi, Murielle Rocancourt, Magalie Duchateau, Arnaud Echard, Thibaut Douché, Adrien Presle, Pascale Zimmermann

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1941. ⟨10.1038/s41467-020-15205-z⟩
Nature Communications, 2020, 11 (1), pp.1941. ⟨10.1038/s41467-020-15205-z⟩

Cytokinesis requires the constriction of ESCRT-III filaments on the side of the midbody, where abscission occurs. After ESCRT recruitment at the midbody, it is not known how the ESCRT-III machinery localizes to the abscission site. To reveal actors i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6078968e56a9ab111e62e49c7551a0a3
https://doaj.org/article/daaf4a7748684ea4ad11e849c544f975