Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Audrey Richter"'
Publikováno v:
Toxicology in Vitro. 24:981-987
Cigarette smoking is associated with chronic obstructive pulmonary disease (COPD)--a term encompassing chronic lung inflammation, chronic bronchitis and emphysema. Goblet cell hyperplasia is a characteristic feature of the lung epithelium in COPD pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40849a3a8bea5c19db2c8fa00b94f04
https://doi.org/10.1016/j.tiv.2009.12.019
https://doi.org/10.1016/j.tiv.2009.12.019
Publikováno v:
Alternatives to Laboratory Animals. 33:239-248
Cigarette smoke is composed of approximately 5% particulate phase and 95% vapour phase by weight. However, routine in vitro toxicological testing of smoke normally only measures the activity of the particulate phase. This study describes a new system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12ce5b723da72bb6e5055d25cf30700
https://doi.org/10.1177/026119290503300310
https://doi.org/10.1177/026119290503300310
Autor:
Sarah M. Puddicombe, Peter H. Howarth, Peter M. Lackie, Audrey Richter, James L. Lordan, Stephen T. Holgate, Donna E. Davies
Publikováno v:
Allergology International. 52:45-52
Asthma is regarded as an inflammatory disorder of the conducting airways characterized by a mast cell, eosinophil and T lymphocyte inflammatory response that is responsive to anti-inflammatory therapy, such as corticosteroids. In more severe and chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da52483b97d1f6fdd6814356caaa440
https://doi.org/10.1046/j.1440-1592.2003.00274.x
https://doi.org/10.1046/j.1440-1592.2003.00274.x
Autor:
Audrey Richter, Ratko Djukanovic, Fabio Bucchieri, Peter H. Howarth, Donna E. Davies, Susan J. Wilson, Jon Ward, James L. Lordan, Sarah M. Puddicombe, Diane Buchanan, Giovanni Zummo, Stephen T. Holgate
Publikováno v:
Scopus-Elsevier
Abnormal apoptotic mechanisms are associated with disease pathogenesis. Because the asthmatic bronchial epithelium is characteristically damaged with loss of columnar epithelial cells, we postulated that this is due to unscheduled apoptosis. Using an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef543dbf49ddae4008426b1bc65f8b25
https://doi.org/10.1165/ajrcmb.27.2.4699
https://doi.org/10.1165/ajrcmb.27.2.4699
Cooperative Effects of Th2 Cytokines and Allergen on Normal and Asthmatic Bronchial Epithelial Cells
Autor:
Fabio Bucchieri, Donna E. Davies, Sarah M. Puddicombe, Susan J. Wilson, James L. Lordan, Athanassias Konstantinidis, Matthew Thornber, Stephen T. Holgate, John W. Holloway, Audrey Richter, Ratko Djukanovic, Diana Buchanan
Publikováno v:
The Journal of Immunology. 169:407-414
In sensitized individuals, exposure to allergens such as Dermatophagoides pteronyssinus (Der p) causes Th2 polarization and release of cytokines, including IL-4 and IL-13. Because Der p extracts also have direct effects on epithelial cells, we hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8bff6d79f30fc65196a49bd3d90f1a
https://doi.org/10.4049/jimmunol.169.1.407
https://doi.org/10.4049/jimmunol.169.1.407
Autor:
Donna E. Davies, Audrey Richter
Publikováno v:
Biochemical Pharmacology. 50:2039-2045
The effect of the anthranoids, anthralin and hypericin, on epidermal growth factor receptor (EGF-R) activation and their degree of specificity was examined. Hypericin, but not anthralin, was found to inhibit binding of [ 125 I]-labelled epidermal gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf6c6a7b547633d182ee19549184383
https://doi.org/10.1016/0006-2952(95)02106-x
https://doi.org/10.1016/0006-2952(95)02106-x
Autor:
Audrey Richter, Karen J. Sargood, Derek W. Anderson, Donna E. Davies, David L. Turner, Nigel G. J. Richards, Ram P. Sharma, Peter Alexander, Stephen G. Chamberlin, John M. Mellor
Publikováno v:
Journal of Biological Chemistry. 270:21062-21067
Two proline mimetics, the enantiomers of 2-azabicyclo[2,2,1]heptane-3-carboxylic acid, have been incorporated in place of Pro30 into synthetic peptides based on the B-loop β-sheet sequence of human transforming growth factor-α (TGF-α) (residues Cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90e633c6a97c61bc038d277f484c47ff
https://doi.org/10.1074/jbc.270.36.21062
https://doi.org/10.1074/jbc.270.36.21062
Autor:
Peter Alexander, Jane E. Collins, Susan J. Holt, Donna E. Davies, Nicola Solic, Audrey Richter, Ian G. Campbell
Publikováno v:
International Journal of Cancer. 62:48-57
Two morphologically distinct cell lines, GP2d and GP5d, derived from the same adenocarcinoma of the colon, have been established and characterised. Both clones have the same genetic changes, consistent with the usual pattern of tumour progression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e03e6851dc5784dc1a1962980b0fbf
https://doi.org/10.1002/ijc.2910620111
https://doi.org/10.1002/ijc.2910620111
Autor:
Douglas Robert Drummond, Stephen G. Chamberlin, Donna E. Davies, Audrey Richter, Jennie MacGarvie, Sarah M. Puddicombe
Publikováno v:
Journal of Biological Chemistry. 270:1612-1616
We have exploited the differences in binding affinities of the chicken epidermal growth factor (EGF) receptor for EGF and transforming growth factor alpha (TGF alpha) to study the role of the B-loop beta-sheet of these ligands in receptor recognition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::266b3ddbdd493d235ba1b7041b25ab0b
https://doi.org/10.1074/jbc.270.4.1612
https://doi.org/10.1074/jbc.270.4.1612
Publikováno v:
Biochemical Pharmacology. 49:367-373
The ability of the immunosuppressive agent FK506 to affect growth of the epidermal growth factor-receptor (EGF-R) overexpressing cell line, A431, was compared with that of the structurally unrelated immunosuppressive compound, cyclosporin A (CyA). Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3032ffa0f10eed19a630f0c98b7ff2c7
https://doi.org/10.1016/0006-2952(94)00423-j
https://doi.org/10.1016/0006-2952(94)00423-j