Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Audrey R. Odom"'
Volatile profiling distinguishes Streptococcus pyogenes from other respiratory streptococcal species
Autor:
Amalia Z. Berna, Joseph A. Merriman, Leah Mellett, Danealle K. Parchment, Michael G. Caparon, Audrey R. Odom John
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT Sore throat is one of the most common complaints encountered in the ambulatory clinical setting. Rapid, culture-independent diagnostic techniques that do not rely on pharyngeal swabs would be highly valuable as a point-of-care strategy to gu
Externí odkaz:
https://doaj.org/article/5c9e8cd99f544ea6936cf0111224424c
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Malaria infection in pregnancy can lead to adverse outcomes for both the pregnant person and fetus. The administration of intermittent preventative therapy (IPTp) with sulfadoxine-pyrimethamine (SP) during pregnancy (IPTp-SP) improves outcomes, inclu
Externí odkaz:
https://doaj.org/article/63d8fc72dc3d467caa6180deff61a492
Autor:
Andrew J. Jezewski, Yu-Hsi Lin, Julie A. Reisz, Rachel Culp-Hill, Yasaman Barekatain, Victoria C. Yan, Angelo D’Alessandro, Florian L. Muller, Audrey R. Odom John
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Glycolysis controls cellular energy, redox balance, and biosynthesis. Antiglycolytic therapies are under investigation for treatment of obesity, cancer, aging, autoimmunity, and microbial diseases. Interrupting glycolysis is highly valued as a therap
Externí odkaz:
https://doaj.org/article/22d7e09907934e49a2840c1a4cc95da1
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
During its complex life cycle, the malaria parasite survives dramatic environmental stresses, including large temperature shifts. Protein prenylation is required during asexual replication of Plasmodium falciparum
Externí odkaz:
https://doaj.org/article/1c9a1476d4c14927929367be53f631cc
Autor:
Ryan C. Henrici, Rachel L. Edwards, Martin Zoltner, Donelly A. van Schalkwyk, Melissa N. Hart, Franziska Mohring, Robert W. Moon, Stephanie D. Nofal, Avnish Patel, Christian Flueck, David A. Baker, Audrey R. Odom John, Mark C. Field, Colin J. Sutherland
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium falciparum to artemisinin, associated with mutations in pfkelch13. Another gene with variants known to modulate the response to artemisinin enco
Externí odkaz:
https://doaj.org/article/783ffd262b134205b1f7de614ed72d61
Autor:
Rachel L. Edwards, Robert C. Brothers, Xu Wang, Maxim I. Maron, Peter D. Ziniel, Patricia S. Tsang, Thomas E. Kraft, Paul W. Hruz, Kim C. Williamson, Cynthia S. Dowd, Audrey R. Odom John
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the met
Externí odkaz:
https://doaj.org/article/539d6d0aabfc46c68f5a489b64e29fac
Autor:
Ann M. Guggisberg, Philip M. Frasse, Andrew J. Jezewski, Natasha M. Kafai, Aakash Y. Gandhi, Samuel J. Erlinger, Audrey R. Odom John
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT In the malaria parasite Plasmodium falciparum, synthesis of isoprenoids from glycolytic intermediates is essential for survival. The antimalarial fosmidomycin (FSM) inhibits isoprenoid synthesis. In P. falciparum, we identified a loss-of-fun
Externí odkaz:
https://doaj.org/article/0d2cdb80aa98443e8071149bc2d037ca
Autor:
Emily S. Mathews, Audrey R. Odom John
Publikováno v:
F1000Research, Vol 7 (2018)
Malaria remains a significant contributor to global human mortality, and roughly half the world’s population is at risk for infection with Plasmodium spp. parasites. Aggressive control measures have reduced the global prevalence of malaria signific
Externí odkaz:
https://doaj.org/article/e242152c188e476c81ab4a37c508d939
Publikováno v:
mSphere, Vol 3, Iss 2 (2018)
ABSTRACT White-tailed deer (Odocoileus virginianus), an ecologically and economically important species, are the most widely distributed large animals in North America. A recent study indicated that up to 25% of all white-tailed deer may be infected
Externí odkaz:
https://doaj.org/article/2a8bc1e043b241b2847fcf13080e814b
Autor:
Rachel L. Edwards, Audrey R. Odom John
Publikováno v:
F1000Research, Vol 5 (2016)
In the past decade, malaria rates have plummeted as a result of aggressive infection control measures and the adoption of artemisinin-based combination therapies (ACTs). However, a potential crisis looms ahead. Treatment failures to standard antimala
Externí odkaz:
https://doaj.org/article/33fdaa6df73e470a80a764868a07e2e8