ZNF768 links oncogenic RAS to cellular senescence

Autor: Romain Villot, Audrey Poirier, Inan Bakan, Karine Boulay, Erlinda Fernández, Romain Devillers, Luciano Gama-Braga, Laura Tribouillard, Andréanne Gagné, Éma Duchesne, Danielle Caron, Jean-Sébastien Bérubé, Jean-Christophe Bérubé, Yan Coulombe, Michèle Orain, Yves Gélinas, Stéphane Gobeil, Yohan Bossé, Jean-Yves Masson, Sabine Elowe, Steve Bilodeau, Venkata Manem, Philippe Joubert, Frédérick A. Mallette, Mathieu Laplante

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

KEY FINDINGS ZNF768 is phosphorylated and degraded upon RAS activation ZNF768 depletion impairs proliferation and causes cellular senescence ZNF768 binds and represses p53 and its overexpression suffices to bypass senescence Elevated ZNF768 levels in

Externí odkaz: https://doaj.org/article/8280dad19e4949b787cc212a7dfd3068

ZNF768 links oncogenic RAS to cellular senescence

Autor: Sabine Elowe, Romain Villot, Yohan Bossé, Stéphane Gobeil, Mathieu Laplante, Inan Bakan, Venkata S. K. Manem, Frédérick A. Mallette, Danielle Caron, Jean-Christophe Bérubé, Steve Bilodeau, Romain Devillers, Yves Gélinas, Yan Coulombe, Laura Tribouillard, Jean-Sébastien Bérubé, Éma Duchesne, Jean-Yves Masson, Michèle Orain, Erlinda Fernández, Luciano Gama-Braga, Audrey Poirier, Karine Boulay, Andréanne Gagné, Philippe Joubert

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications

RAS proteins are GTPases that lie upstream of a signaling network impacting cell fate determination. How cells integrate RAS activity to balance proliferation and cellular senescence is still incompletely characterized. Here, we identify ZNF768 as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d12920290f2df31a87a5119c8e325c9
https://doaj.org/article/8280dad19e4949b787cc212a7dfd3068

ZNF768 Expression Associates with High Proliferative Clinicopathological Features in Lung Adenocarcinoma

Autor: Michèle Orain, Audrey Poirier, Meagan Marcoux, Sophie Plante, Andréanne Gagné, Philippe Joubert, Mathieu Laplante, Philippe Laflamme, David Joubert

Publikováno v: Cancers, Vol 13, Iss 4136, p 4136 (2021)
Cancers
Volume 13
Issue 16

Simple Summary Zinc-finger protein 768 (ZNF768) is a transcription factor that was recently shown to promote proliferation and repress senescence downstream of growth factor signaling in vitro. This protein was found to be overexpressed in a small co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3806e5298ebe76c87ee3d18d106a95
https://www.mdpi.com/2072-6694/13/16/4136

Auto-deconvolution and molecular networking of gas chromatography-mass spectrometry data

Autor: Ilaria Belluomo, Morgan Panitchpakdi, Aleksandr Smirnov, Mélissa Nothias-Esposito, Alexey V. Melnik, Gaud Dervilly, Rachel J. Dutton, Adolfo Amézquita, Vasilis Vasiliou, Zheng Zhang, Daniel Petras, Carrie D. Nicora, Audrey Poirier, James T. Morton, Ivan Laponogov, George B. Hanna, Sneha P. Couvillion, Biswapriya B. Misra, Robin Schmid, Wout Bittremieux, Raphaël Lugan, Brooke A. Anderson, Yann Guitton, Chris Callewaert, Kenneth L. Jones, Robert A. Quinn, Rob Knight, Larisa N. Kulikova, Itzhak Mizrahi, Erika M. Zink, Mabel Gonzalez, Sophie L. F. Doran, Rachel Gregor, Pauline Le Boulch, Kelem Gashu, Xiuxia Du, Michael M. Meijler, Kirill Veselkov, Chao Song, Elizabeth Humston-Fulmer, Noga Sikron Persi, Justin J. J. van der Hooft, Dennis Veselkov, Monica Guma, Kathleen Dorrestein, Saleh Alseekh, Roxana Coras, Chiara Carazzone, Thomas O. Metz, Aaron Fait, Andrea Georgina Albarracín Orio, Alexander A. Aksenov, Jose U. Scher, Andrea M. Smania, Bruno Le Bizec, Stav Eyal, Dinesh Kumar Barupal, Pieter C. Dorrestein, Alisdair R. Fernie, Reza Mirnezami, S. Prévost, Louis-Félix Nothias, Meagan C. Burnet, Viatcheslav B. Artaev, Mingxun Wang, Katherine N. Maloney, Julia Manasson, Madeleine Ernst, Roman S. Borisov, Amina Bouslimani

Publikováno v: Nat Biotechnol
Nature biotechnology
Aksenov, Alexander A., Laponogov, Ivan, Zhang, Zheng, Doran, Sophie L. F., Belluomo, Ilaria, Veselkov, Dennis, Bittremieux, Wout, Nothias, Louis Felix, Nothias-Esposito, Mélissa, Maloney, Katherine N., Misra, Biswapriya B., Melnik, Alexey V., Smirnov, Aleksandr, Du, Xiuxia, Jones, Kenneth L., Dorrestein, Kathleen, Panitchpakdi, Morgan, Ernst, Madeleine, van der Hooft, Justin J. J., Gonzalez, Mabel, Carazzone, Chiara, Amézquita, Adolfo, Callewaert, Chris, Morton, James T., Quinn, Robert A., Bouslimani, Amina, Orio, Andrea Albarracín, Petras, Daniel, Smania, Andrea M., Couvillion, Sneha P., Burnet, Meagan C., Nicora, Carrie D., Zink, Erika, Metz, Thomas O., Artaev, Viatcheslav, Humston-Fulmer, Elizabeth, Gregor, Rachel, Meijler, Michael M., Mizrahi, Itzhak, Eyal, Stav, Anderson, Brooke, Dutton, Rachel, Lugan, Raphaël, Boulch, Pauline Le, Guitton, Yann, Prevost, Stephanie, Poirier, Audrey, Dervilly, Gaud, Le Bizec, Bruno, Fait, Aaron, Persi, Noga Sikron, Song, Chao, Gashu, Kelem, Coras, Roxana, Guma, Monica, Manasson, Julia, Scher, Jose U., Barupal, Dinesh Kumar, Alseekh, Saleh, Fernie, Alisdair R., Mirnezami, Reza, Vasiliou, Vasilis, Schmid, Robin, Borisov, Roman S., Kulikova, Larisa N., Knight, Rob, Wang, Mingxun, Hanna, George B., Dorrestein, Pieter C. and Veselkov, Kirill (2021) Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data. Nature Biotechnology, 39 (2). ISSN 1087-0156
Nature Biotechnology
Nature Biotechnology, 39(2), 169-173
Nature Biotechnology, Nature Publishing Group, 2021, 39 (2), pp.169-173. ⟨10.1038/s41587-020-0700-3⟩
Nature Biotechnology 39 (2021) 2
Nature biotechnology, vol 39, iss 2

We engineered a machine learning approach, MSHub, to enable auto-deconvolution of gas chromatography–mass spectrometry (GC–MS) data. We then designed workflows to enable the community to store, process, share, annotate, compare and perform molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ff89483759269c68c13571b23db181
http://hdl.handle.net/10044/1/84598