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Recombinant cell penetrating peptides and intrabodies targeting membrane-bound mutated KRAS antigens
Autor:
Jeremy Jeack Ceen Ng, Zhi Xuan Low, Larsen Alessandro, Jung Yin Fong, Audrey Onn Yi Au Yong, Minn-E Ng, Michelle Yee Mun Teo, Hok Chai Yam, Lionel Lian Aun In
Publikováno v:
Asia Pacific Journal of Molecular Biology and Biotechnology. :54-68
One of the drivers for early carcinogenesis involves specific somatic point substitution mutations in the KRAS gene which damages its ability to conduct signal transduction. Although antibodies can be used for the targeting of KRAS antigen, their loc