Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Audrey Olshefsky"'
Autor:
Anindya Roy, Lei Shi, Ashley Chang, Xianchi Dong, Andres Fernandez, John C. Kraft, Jing Li, Viet Q. Le, Rebecca Viazzo Winegar, Gerald Maxwell Cherf, Dean Slocum, P. Daniel Poulson, Garrett E. Casper, Mary L. Vallecillo-Zúniga, Jonard Corpuz Valdoz, Marcos C. Miranda, Hua Bai, Yakov Kipnis, Audrey Olshefsky, Tanu Priya, Lauren Carter, Rashmi Ravichandran, Cameron M. Chow, Max R. Johnson, Suna Cheng, McKaela Smith, Catherine Overed-Sayer, Donna K. Finch, David Lowe, Asim K. Bera, Gustavo Matute-Bello, Timothy P. Birkland, Frank DiMaio, Ganesh Raghu, Jennifer R. Cochran, Lance J. Stewart, Melody G. Campbell, Pam M. Van Ry, Timothy Springer, David Baker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance. Compounds that can discriminate between homologous αvβ6 and αvβ8 and other RGD integri
Externí odkaz:
https://doaj.org/article/e3c311aafe5446188603fdc35eee2511
Autor:
Daniel Ellis, Julia Lederhofer, Oliver J. Acton, Yaroslav Tsybovsky, Sally Kephart, Christina Yap, Rebecca A. Gillespie, Adrian Creanga, Audrey Olshefsky, Tyler Stephens, Deleah Pettie, Michael Murphy, Claire Sydeman, Maggie Ahlrichs, Sidney Chan, Andrew J. Borst, Young-Jun Park, Kelly K. Lee, Barney S. Graham, David Veesler, Neil P. King, Masaru Kanekiyo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Influenza virus neuraminidase (NA) is a drug target and a potential vaccine antigen. Here, the authors provide a detailed analysis of the conformational stability of NA, and show how expression and stability of recombinant NA antigens can be strength
Externí odkaz:
https://doaj.org/article/e57f3c320a9b4bb08e43192a409483e7
Autor:
Ashley Vater, Ryan Caster, Hugh Haddox, Audrey Olshefsky, Meerit Said, Neil P. King, Justin B. Siegel
Publikováno v:
Frontiers in Education, Vol 7 (2022)
In response to the limited research experiences for young scholars during the COVID-19 pandemic and community interest, we developed the Pre-College Rosetta Internship Opportunity (PCR-IO). The mission of PCR-IO was to offer a program to increase equ
Externí odkaz:
https://doaj.org/article/eda8668fde374c5a86ef078ef61ef58b
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147494 (2016)
Two-component signaling (2CS) systems enable bacterial cells to respond to changes in their local environment, often using a membrane-bound sensor protein and a cytoplasmic responder protein to regulate gene expression. Previous work has shown that E
Externí odkaz:
https://doaj.org/article/323054e8e04e4e5db5b10a18d60d677d
Publikováno v:
Bioconjugate chemistry. 33(11)
Despite remarkable advances over the past several decades, many therapeutic nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity, optimizing biodistribution, and engineering environmental responsiveness are key o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d9f3046b82ebeb605b8289566d5736
https://pubmed.ncbi.nlm.nih.gov/35487503
https://pubmed.ncbi.nlm.nih.gov/35487503
Autor:
Audrey Olshefsky, Neil P. King
Publikováno v:
Trends Biochem Sci
Viruses are fascinating molecular machines that inspire many therapeutic design efforts. Tetter, Terasaka & Steinauer et al. recently reported the laboratory evolution of a synthetic nucleocapsid from a bacterial enzyme. Their work sheds light on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb04e9cd10e4dc08f483933ef206737
https://pubmed.ncbi.nlm.nih.gov/34456123
https://pubmed.ncbi.nlm.nih.gov/34456123
Autor:
Daniel Ellis, Julia Lederhofer, Oliver J. Acton, Yaroslav Tsybovsky, Sally Kephart, Christina Yap, Rebecca A. Gillespie, Adrian Creanga, Audrey Olshefsky, Tyler Stephens, Deleah Pettie, Michael Murphy, Claire Sydeman, Maggie Ahlrichs, Sidney Chan, Andrew J. Borst, Young-Jun Park, Kelly K. Lee, Barney S. Graham, David Veesler, Neil P. King, Masaru Kanekiyo
Publikováno v:
Nature communications. 13(1)
Influenza virus neuraminidase (NA) is a major antiviral drug target and has recently reemerged as a key target of antibody-mediated protective immunity. Here we show that recombinant NAs across non-bat subtypes adopt various tetrameric conformations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbce2f01d241af84b4da6be1fbbfbf0
https://pubmed.ncbi.nlm.nih.gov/35383176
https://pubmed.ncbi.nlm.nih.gov/35383176
Autor:
Anusha Rajan, Audrey Olshefsky, JayLee M. Johnson, Suzie H. Pun, Colin Correnti, Mesfin M. Gewe, Vishaka Muhunthan, Scott E. Boyken, Stanley R. Riddell, Marc J. Lajoie, Alexander I. Salter, Matthew J. Bick, Alisha Nguyen, David Baker, Jilliane Bruffey, Garreck Lenz, Alfredo Quijano-Rubio, Robert A. Langan
Publikováno v:
Cell Res
Science
Science
Logic at the cell surface A major challenge in medical interventions is to target only diseased cells. Although there are biomarkers characteristic of certain cancers, for example, it is unlikely that a single marker can specify a particular cell typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fcbb4306bd37d6b24624ad299a3621a
https://pubmed.ncbi.nlm.nih.gov/32978606
https://pubmed.ncbi.nlm.nih.gov/32978606
Publikováno v:
Advanced Drug Delivery Reviews. 130:39-49
Targeting ligands are used in drug delivery to improve drug distribution to desired cells or tissues and to facilitate cellular entry. In vivo biopanning, whereby billions of potential ligand sequences are screened in biologically-relevant and comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601222183101187e633e1cc30e8a4c50
https://doi.org/10.1016/j.addr.2018.06.015
https://doi.org/10.1016/j.addr.2018.06.015
Autor:
Suzie H. Pun, Patrick S. Stayton, Meilyn Sylvestre, Audrey Olshefsky, Kefan Song, Selvi Srinivasan, David J. Peeler, Albert Yen, Dinh Chuong Nguyen, Shixian Lv
Publikováno v:
Adv Healthc Mater
Peptide-based cancer vaccines offer production and safety advantages but have had limited clinical success due to their intrinsic instability, rapid clearance, and low cellular uptake. Nanoparticle-based delivery vehicles can improve the in vivo stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c20d318e71c046909a3ba6c6df96b03
https://doi.org/10.1002/adhm.202101651
https://doi.org/10.1002/adhm.202101651