Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Audrey Nedelec"'
Autor:
Oleh Zagrijtschuk, Harini Nivarthi, Thomas Balligand, Roman Lesyk, Ruochen Jia, Vasyl Atamanyuk, Stefan N. Constantinescu, Erica Xu, Audrey Nedelec, Leon Kutzner, Jakob Weinzierl, Stefan Kubicek, Robert Kralovics
Publikováno v:
Blood, Vol. 137, no. 14, p. 1920-1931 (2021)
Somatic mutations of calreticulin (CALR) have been identified as a main disease driver of myeloproliferative neoplasms, suggesting that development of drugs targeting mutant CALR is of great significance. Site-directed mutagenesis in the N-glycan bin
Autor:
Caroline Marty, Isabelle Plo, Audrey Nedelec, Laure Touchard, Camelia Benlabiod, Hana Raslova, Stefan N. Constantinescu, Philippe Rameau, Maira da Costa Cacemiro, William Vainchenker, Jean-Luc Villeval, Valérie Edmond, Delphine Muller, Patrick Gonin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, Vol. 11, no. 1, p. 4886 [1-15] (2020)
Nature Communications
Nature communications, Vol. 11, no. 1, p. 4886 [1-15] (2020)
Nature Communications
Somatic mutations in the calreticulin (CALR) gene are associated with approximately 30% of essential thrombocythemia (ET) and primary myelofibrosis (PMF). CALR mutations, including the two most frequent 52 bp deletion (del52) and 5 bp insertion (ins5
Autor:
Nicolas Papadopoulos, Audrey Nédélec, Allison Derenne, Teodor Asvadur Şulea, Christian Pecquet, Ilyas Chachoua, Gaëlle Vertenoeil, Thomas Tilmant, Andrei-Jose Petrescu, Gabriel Mazzucchelli, Bogdan I. Iorga, Didier Vertommen, Stefan N. Constantinescu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
In myeloproliferative neoplasms, frameshift mutants of calreticulin turn into rogue cytokines by inducing constitutive activation of the Thrombopoietin Receptor (TpoR). Here, the authors define how mutant calreticulin acquires specificity for TpoR bi
Externí odkaz:
https://doaj.org/article/2608cc9507e54cfda715fbc3e86b7d63
Autor:
Camélia Benlabiod, Maira da Costa Cacemiro, Audrey Nédélec, Valérie Edmond, Delphine Muller, Philippe Rameau, Laure Touchard, Patrick Gonin, Stefan N. Constantinescu, Hana Raslova, Jean-Luc Villeval, William Vainchenker, Isabelle Plo, Caroline Marty
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Calreticulin del52 and ins5 mutations induce two phenotypically distinct myeloproliferative neoplasms in patients. Here the authors show that modeling these mutations in knock-in mice recapitulate the two diseases and highlight how they impact the di
Externí odkaz:
https://doaj.org/article/ce23c15ed9354d4c9eb59d46f3b21b44