Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Audrey Nédélec"'
Autor:
Nicolas Papadopoulos, Audrey Nédélec, Allison Derenne, Teodor Asvadur Şulea, Christian Pecquet, Ilyas Chachoua, Gaëlle Vertenoeil, Thomas Tilmant, Andrei-Jose Petrescu, Gabriel Mazzucchelli, Bogdan I. Iorga, Didier Vertommen, Stefan N. Constantinescu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
In myeloproliferative neoplasms, frameshift mutants of calreticulin turn into rogue cytokines by inducing constitutive activation of the Thrombopoietin Receptor (TpoR). Here, the authors define how mutant calreticulin acquires specificity for TpoR bi
Externí odkaz:
https://doaj.org/article/2608cc9507e54cfda715fbc3e86b7d63
Autor:
Camélia Benlabiod, Maira da Costa Cacemiro, Audrey Nédélec, Valérie Edmond, Delphine Muller, Philippe Rameau, Laure Touchard, Patrick Gonin, Stefan N. Constantinescu, Hana Raslova, Jean-Luc Villeval, William Vainchenker, Isabelle Plo, Caroline Marty
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Calreticulin del52 and ins5 mutations induce two phenotypically distinct myeloproliferative neoplasms in patients. Here the authors show that modeling these mutations in knock-in mice recapitulate the two diseases and highlight how they impact the di
Externí odkaz:
https://doaj.org/article/ce23c15ed9354d4c9eb59d46f3b21b44
Autor:
Nicolas Papadopoulos, Ajda Pristavec, Gabriel Levy, Audrey Nédélec, Judith Staerk, Stefan N. Constantinescu
Publikováno v:
Blood. 140:3878-3879
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fac40b8ad9e8463c6c362f7737af98c6
https://doi.org/10.1182/blood-2022-166405
https://doi.org/10.1182/blood-2022-166405
Autor:
Stefan N. Constantinescu, Nicolas Papadopoulos, Audrey Nédélec, Allison Derenne, Teodor Asvadur Şulea, Christian Pecquet, Ilyas Chachoua, Gaëlle Vertenoeil, Thomas Tilmant, Andrei-Jose Petrescu, Gabriel Mazuccheli, Didier Vertommen
Calreticulin (CALR) is a master lectin chaperone that normally guides the proper folding of integral membrane proteins in the endoplasmic reticulum. In healthy cells, CALR transiently and non-specifically interacts with thousands of immature N-glycos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b393c57f4e2df7456bcef826c4abfd8
https://doi.org/10.21203/rs.3.rs-1605601/v1
https://doi.org/10.21203/rs.3.rs-1605601/v1
Penttinen syndrome-associated PDGFRB Val665Ala variant causes aberrant constitutive STAT1 signalling
Autor:
Audrey Nédélec, Emilie M. Guérit, Guillaume Dachy, Sandrine Lenglez, Lok San Wong, Florence A. Arts, Jean‐Baptiste Demoulin
Publikováno v:
Journal of cellular and molecular medicine, Vol. 26, no.99, p. 99 (2022)
Penttinen syndrome is a rare progeroid disorder caused by mutations in platelet-derived growth factor (PDGF) receptor beta (encoded by the PDGFRB proto-oncogene) and characterized by a prematurely aged appearance with lipoatrophy, skin lesions, thin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53094c1640192046fc6a26f23b342732
https://hdl.handle.net/2078.1/261936
https://hdl.handle.net/2078.1/261936