Identifying and targeting cancer stem cells in leiomyosarcoma: prognostic impact and role to overcome secondary resistance to PI3K/mTOR inhibition

Autor: Benjamin Fourneaux, Aurélien Bourdon, Bérengère Dadone, Carlo Lucchesi, Scott R. Daigle, Elodie Richard, Audrey Laroche-Clary, François Le Loarer, Antoine Italiano

Publikováno v: Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-12 (2019)

Abstract Background Leiomyosarcoma (LMS) is one of the most frequent soft tissue sarcoma subtypes and is characterized by a consistent deregulation of the PI3K/mTOR pathway. Cancer stem cells (CSCs) have been poorly studied in soft tissue sarcomas. I

Externí odkaz: https://doaj.org/article/baa3e9b084fc41328ab4c41e9f8692ff

Combined targeting of MDM2 and CDK4 is synergistic in dedifferentiated liposarcomas

Autor: Audrey Laroche-Clary, Vanessa Chaire, Marie-Paule Algeo, Marie-Alix Derieppe, François L. Loarer, Antoine Italiano

Publikováno v: Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-10 (2017)

Abstract Purpose MDM2 and CDK4 are frequently co-amplified in well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS). We aimed to determine whether combined MDM2/CDK4 targeting is associated with higher antitumour activity than a single agent

Externí odkaz: https://doaj.org/article/d565165539b94e5fab3f124b61aa7b7e

Data from Cytochrome P450 1B1 Gene Polymorphisms as Predictors of Anticancer Drug Activity: Studies with In vitro Models

Autor: Jacques Robert, Takao Yamori, Valérie Le Morvan, Audrey Laroche-Clary

Cytochrome P450 1B1 (CYP1B1) is found in tumor tissue and is suspected to play a role in oncogenesis and drug resistance. CYP1B1 gene polymorphisms have been associated with the risk of developing lung and other cancers. They may be associated with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6412173389554a13a54072254b20a1b3
https://doi.org/10.1158/1535-7163.c.6536700.v1

Abstract 1509: Genome-wide CRISPR/Cas9 library screening identified THRAP3 as a critical driver for resistance to ATR inhibitor in sarcomas revealing synthetic lethality with ATM inhibition

Autor: Mariella Spalato, Audrey Laroche-Clary, Vanessa Chaire, Antoine Italiano

Publikováno v: Cancer Research. 82:1509-1509

Background: ATR plays a crucial role in maintaining genomic integrity by responding to a large spectrum of DNA damage, including double strand breaks (DSBs) that interfere with replication. We have previously demo started that ATR inhibition is assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eccdf33d628d71edcf4a351684bb3dfc
https://doi.org/10.1158/1538-7445.am2022-1509

Novel Therapeutic Insights in Dedifferentiated Liposarcoma: A Role for FGFR and MDM2 Dual Targeting

Autor: Ilaria Di Mauro, Emmanuel Chamorey, Florence Pedeutour, Audrey Laroche-Clary, Bérengère Dadone-Montaudié, Vanessa Chaire, Laurence Bianchini, Aline Mongis, François Bertucci, Antoine Italiano, Isabelle Birtwisle-Peyrottes, Renaud Schiappa, François Le Loarer, Pascal Finetti, Jean-François Michiels

Publikováno v: Cancers
Cancers, MDPI, 2020, 12, ⟨10.3390/cancers12103058⟩
Cancers, Vol 12, Iss 3058, p 3058 (2020)
Volume 12
Issue 10
Cancers, 2020, 12, ⟨10.3390/cancers12103058⟩

We aimed to evaluate the therapeutic potential of the pan-FGFR inhibitor erdafitinib to treat dedifferentiated liposarcoma (DDLPS). FGFR expression and their prognostic value were assessed in a series of 694 samples of well-differentiated/dedifferent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edb69319cc591b270e236fdad13bd78
https://hal.archives-ouvertes.fr/hal-03034592/document