Výsledky vyhledávání - "Audrey Kinter"

The Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

Autor: Irini Sereti, Gregg Roby, Marie A. O'Shea, Jonathan P. McNally, Audrey Kinter, Emily J. Godbout, Anthony S. Fauci

Publikováno v: The Journal of Immunology. 181:6738-6746

The programmed death (PD)-1 molecule and its ligands (PD-L1 and PD-L2), negative regulatory members of the B7 family, play an important role in peripheral tolerance. Previous studies have demonstrated that PD-1 is up-regulated on T cells following TC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f941386a081aa7142f94a3a6f285d9
https://doi.org/10.4049/jimmunol.181.10.6738

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CD25+Regulatory T Cells Isolated from HIV-Infected Individuals Suppress The Cytolytic And Nonlytic Antiviral Activity of HIV-specific CD8+T Cells in Vitro

Autor: Mark Connors, Audrey Kinter, Gregg Roby, Angeline O'Shea, Colin Kovacs, Robin Horak, Anthony S. Fauci, Stephen A. Migueles, Robert B. Jackson, Jonathan P. McNally, Lindsey Riggin, Melanie Sion, Yin Lin

Publikováno v: AIDS Research and Human Retroviruses. 23:438-450

HIV infection is characterized by CD4(+) T cell depletion and progressive immune dysfunction; particularly impacted are HIV-specific T cell responses. An important component of immune-mediated control of HIV replication, killing of infected cells, ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc026f01ba9579852f38b86251541c8
https://doi.org/10.1089/aid.2006.0162

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Suppression of HIV-specific T cell activity by lymph node CD25 + regulatory T cells from HIV-infected individuals

Autor: Lindsey Riggin, Gregg Roby, Robert B. Jackson, Audrey Kinter, Jonathan P. McNally, Anthony S. Fauci

Publikováno v: Proceedings of the National Academy of Sciences. 104:3390-3395

CD25 + CD4 + FoxP3 + regulatory T (Treg) cells isolated from the peripheral blood of asymptomatic HIV-infected individuals have been demonstrated to significantly suppress HIV-specific immune responses in vitro . CD25 + Treg cell suppressor activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379eeb0bfaf34732be6788aa88b20ca7
https://doi.org/10.1073/pnas.0611423104

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Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection

Autor: Audrey Kinter, Manuela Fogli, Emanuela Marcenaro, Daniela Pende, Andrea la Sala, Annahita Farschi, Dean Follmann, Gabriella Lombardo, Domenico Mavilio, Saida Ortolano, Anthony S. Fauci, Colin Kovacs, Roby Gregg, Alessandro Moretta

Publikováno v: The Journal of Experimental Medicine

In this study, we demonstrate that the in vitro interactions between a CD56neg/CD16pos (CD56neg) subset of natural killer (NK) cells and autologous dendritic cells (DCs) from HIV-1–infected viremic but not aviremic individuals are markedly impaired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d7e86dcd8fa8357aa00de561652426
https://doi.org/10.1084/jem.20060894

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Contrasting Effects of Low-Dose IL-2 on Vaccine-Boosted Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cells in Macaques Chronically Infected with SIVmac251

Autor: Anna Hryniewicz, Elzbieta Tryniszewska, Kendall A. Smith, Marcin Moniuszko, Janos Nacsa, Audrey Kinter, Wen-Po Tsai, Yvette Edghill-Smith, Genoveffa Franchini, David Venzon

Publikováno v: The Journal of Immunology. 174:1913-1921

IL-2, the first cytokine discovered with T cell growth factor activity, is now known to have pleiotropic effects on T cells. For example, it can promote growth, survival, and differentiation of Ag-selected cells, or facilitate Ag-induced cell death o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee5c3fc7ee2c7d821cd2d5f983cc8af
https://doi.org/10.4049/jimmunol.174.4.1913

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Neonatal Natural Killer Cells Produce Chemokines and Suppress HIV Replicationin Vitro

Autor: Robert B. Jackson, Helene B. Bernstein, Anthony S. Fauci, Audrey Kinter

Publikováno v: AIDS Research and Human Retroviruses. 20:1189-1195

The innate immune system may be critical in the prevention of perinatal HIV infection. Since neonates have limited immunological experience, they may rely more on the ability of the innate immune system to defend against infection than their adult co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22da2b340681954d550f7b1301504b6
https://doi.org/10.1089/aid.2004.20.1189

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CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status

Autor: Yin-Shiou Lin, Maria Planta, Alicia Bell, Steven F. Ziegler, Robert B. Jackson, Marybeth Daucher, Sarah Kern, Mary McGlaughlin, Audrey Kinter, Anthony S. Fauci, Margaret Hennessey

Publikováno v: The Journal of Experimental Medicine

Human immunodeficiency virus (HIV) disease is associated with loss of CD4+ T cells, chronic immune activation, and progressive immune dysfunction. HIV-specific responses, particularly those of CD4+ T cells, become impaired early after infection, befo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8be52be0c0d20f2d707cd913620ffe
https://doi.org/10.1084/jem.20032069

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HIV Envelope Induces Virus Expression from Resting CD4+ T Cells Isolated from HIV-Infected Individuals in the Absence of Markers of Cellular Activation or Apoptosis

Autor: Joseph W. Adelsberger, Eileen T. Donoghue, James Arthos, Claudia Cicala, Ronald L. Rabin, Linda A. Ehler, Yin Lin, Anthony S. Fauci, Audrey Kinter, Robert W. Jackson, Craig A Umscheid

Publikováno v: The Journal of Immunology. 170:2449-2455

Resting CD4+ T cells containing integrated HIV provirus constitute one of the long-lived cellular reservoirs of HIV in vivo. This cellular reservoir of HIV had been thought to be quiescent with regard to virus replication based on the premise that HI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cc5250f25bb608e39714cf49644638
https://doi.org/10.4049/jimmunol.170.5.2449

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Chemokines, cytokines and HIV: a complex network of interactions that influence HIV pathogenesis

Autor: Claudia Cicala, Audrey Kinter, James Arthos, Anthony S. Fauci

Publikováno v: Immunological Reviews. 177:88-98

The important role of chemokine receptors in HIV pathogenesis is becoming increasingly apparent. The level at which certain chemokine receptors that serve as HIV co-receptors are available influences the susceptibility of a CD4+ cell to viral infecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a48e62e4618bd76e96976958e87e98e
https://doi.org/10.1034/j.1600-065x.2000.17708.x

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Peripheral Blood-Derived CD34+ Progenitor Cells: CXC Chemokine Receptor 4 and CC Chemokine Receptor 5 Expression and Infection by HIV

Autor: Margaret E. Ruiz, Claudia Cicala, James Arthos, Audrey Kinter, Andrew T. Catanzaro, Joseph Adelsberger, Kevin L. Holmes, Oren J. Cohen, Anthony S. Fauci

Publikováno v: The Journal of Immunology. 161:4169-4176

The present study demonstrates cell surface expression of both CXC chemokine receptor 4 (CXCR4) and CC chemokine receptor 5 (CCR5), major coreceptors for T cell-tropic and macrophage-tropic strains of HIV, respectively, on CD34+ progenitor cells deri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d607a70761efb4b425987c9a16f97c6d
https://doi.org/10.4049/jimmunol.161.8.4169

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