Výsledky vyhledávání - "Audrey J Weber"

Akademický článek

Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice

Autor: Anna K. Cook, Kelsey M. Greathouse, Phaedra N. Manuel, Noelle H. Cooper, Juliana M. Eberhardt, Cameron D. Freeman, Audrey J. Weber, Jeremy H. Herskowitz, Andrew E. Arrant

Publikováno v: Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)

Abstract Loss-of-function mutations in the progranulin (GRN) gene are an autosomal dominant cause of Frontotemporal Dementia (FTD). These mutations typically result in haploinsufficiency of the progranulin protein. Grn +/– mice provide a model for

Externí odkaz: https://doaj.org/article/dcc01e54cc45449c9600e182fdd786bb

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Akademický článek

Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons

Autor: Audrey J. Weber, Ashley B. Adamson, Kelsey M. Greathouse, Julia P. Andrade, Cameron D. Freeman, Jung Vin Seo, Rosaria J. Rae, Courtney K. Walker, Jeremy H. Herskowitz

Publikováno v: Molecular Brain, Vol 14, Iss 1, Pp 1-19 (2021)

Abstract Rho-associated kinase isoform 2 (ROCK2) is an attractive drug target for several neurologic disorders. A critical barrier to ROCK2-based research and therapeutics is the lack of a mouse model that enables investigation of ROCK2 with spatial

Externí odkaz: https://doaj.org/article/4e3a6b68158042169c1a16a3a1c2db46

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Akademický článek

Perspectives on ROCK2 as a Therapeutic Target for Alzheimer’s Disease

Autor: Audrey J. Weber, Jeremy H. Herskowitz

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2021)

Rho-associated coiled-coil containing kinase isoform 2 (ROCK2) is a member of the AGC family of serine/threonine kinases and an extensively studied regulator of actin-mediated cytoskeleton contractility. Over the past decade, new evidence has emerged

Externí odkaz: https://doaj.org/article/62bd4bd1c05e4d9cb13f2741bf8db4c8

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Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length

Autor: Courtney K Walker, Kelsey M Greathouse, Jennifer J Tuscher, Eric B Dammer, Audrey J Weber, Evan Liu, Kendall A Curtis, Benjamin D Boros, Cameron D Freeman, Jung Vin Seo, Raksha Ramdas, Cheyenne Hurst, Duc M Duong, Marla Gearing, Charles F Murchison, Jeremy J Day, Nicholas T Seyfried, Jeremy H Herskowitz

Publikováno v: The Journal of Neuroscience. :JN-RM

Proteomic studies utilizing postmortem human brain tissue samples have yielded robust assessments of the aging and neurodegenerative disease(s) proteomes. While these analyses provide lists of molecular alterations in human conditions, like Alzheimer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7422eed01e309d618f32cf0a54bc7bd
https://doi.org/10.1523/jneurosci.2102-22.2023

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