Gut microbiota-mediated polyphenol metabolism is restrained by parasitic whipworm infection and associated with altered immune function in mice

Autor: Audrey Inge Schytz Andersen-Civil, Pankaj Arora, Ling Zhu, Laura J. Myhill, Nilay Büdeyri Gökgöz, Josue L. Castro-Mejia, Milla M. Leppä, Lars H. Hansen, Jacob Lessard-Lord, Juha-Pekka Salminen, Stig M. Thamsborg, Dennis Sandris Nielsen, Yves Desjardins, Andrew R. Williams

Publikováno v: Gut Microbes, Vol 16, Iss 1 (2024)

Polyphenols are phytochemicals commonly found in plant-based diets which have demonstrated immunomodulatory and anti-inflammatory properties. However, the interplay between polyphenols and pathogens at mucosal barrier surfaces has not yet been elucid

Externí odkaz: https://doaj.org/article/233c6a6acbed41518fd7900f4017b093

Dietary proanthocyanidins promote localized antioxidant responses in porcine pulmonary and gastrointestinal tissues during Ascaris suum-induced type 2 inflammation

Autor: Audrey Inge Schytz Andersen‐Civil, Laura J. Myhill, Nilay Büdeyri Gökgöz, Marica T. Engström, Helena Mejer, Ling Zhu, Wayne E. Zeller, Juha‐Pekka Salminen, Lukasz Krych, Charlotte Lauridsen, Dennis S. Nielsen, Stig M. Thamsborg, Andrew R. Williams

Publikováno v: Andersen-Civil, A I S, Myhill, L J, Büdeyri Gökgöz, N, Engström, M T, Mejer, H, Zhu, L, Zeller, W E, Salminen, J P, Krych, L, Lauridsen, C, Nielsen, D S, Thamsborg, S M & Williams, A R 2022, ' Dietary proanthocyanidins promote localized antioxidant responses in porcine pulmonary and gastrointestinal tissues during Ascaris suum-induced type 2 inflammation ', FASEB Journal, vol. 36, no. 4, e22256 . https://doi.org/10.1096/fj.202101603RR

Proanthocyanidins (PAC) are dietary polyphenols with putative anti-inflammatory and immunomodulatory effects. However, whether dietary PAC can regulate type-2 immune function and inflammation at mucosal surfaces remains unclear. Here, we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81dab10227351f7fe9c533c9f8b703f1
https://pure.au.dk/portal/da/publications/dietary-proanthocyanidins-promote-localized-antioxidant-responses-in-porcine-pulmonary-and-gastrointestinal-tissues-during-ascaris-suuminduced-type-2-inflammation(28b7d200-a799-45bc-84c1-7b435f3f6ebe).html