Translational development of a tumor junction opening technology

Autor: Jiho Kim, Chang Li, Hongjie Wang, Swarnendu Kaviraj, Sanjay Singh, Laxman Savergave, Arjun Raghuwanshi, Sucheol Gil, Audrey Germond, Audrey Baldessari, Bingmae Chen, Steve Roffler, Pascal Fender, Charles Drescher, Darrick Carter, André Lieber

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Our goal is to overcome treatment resistance in ovarian cancer patients which occurs in most cases after an initial positive response to chemotherapy. A central resistance mechanism is the maintenance of desmoglein-2 (DSG2) positive tight ju

Externí odkaz: https://doaj.org/article/f750a078157146a4b349ea4bf8b95d18

In vivo HSC transduction in rhesus macaques with an HDAd5/3+ vector targeting desmoglein 2 and transiently overexpressing cxcr4

Autor: Hongjie Wang, Audrey Germond, Chang Li, Sucheol Gil, Jiho Kim, Hans-Peter Kiem, André Lieber

Publikováno v: Blood Advances. 6:4360-4372

We developed a new in vivo hematopoietic stem cell (HSC) gene therapy approach that involves only IV injections and does not require myeloablation/conditioning and HSC transplantation. In this approach, HSCs are mobilized from the bone marrow into th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b7455e6975599e3c59c06e8d5f20eb
https://doi.org/10.1182/bloodadvances.2022007975

Safe and efficient in vivo hematopoietic stem cell transduction in nonhuman primates using HDAd5/35++ vectors

Autor: Chang Li, Hongjie Wang, Sucheol Gil, Audrey Germond, Connie Fountain, Audrey Baldessari, Jiho Kim, Zhinan Liu, Aphrodite Georgakopoulou, Stefan Radtke, Tamás Raskó, Amit Pande, Christina Chiang, Eli Chin, Evangelia Yannaki, Zsuzsanna Izsvák, Thalia Papayannopoulou, Hans-Peter Kiem, André Lieber

Publikováno v: Molecular Therapy. Methods & Clinical Development
Mol Ther Methods Clin Dev
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss, Pp 127-141 (2022)

We tested a new in vivo hematopoietic stem cell (HSC) transduction/selection approach in rhesus macaques using HSC-tropic, integrating, helper-dependent adenovirus vectors (HDAd5/35++) designed for the expression of human γ-globin in red blood cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83aa2ec859bdac6a38e1e379e1f7b066
http://europepmc.org/articles/PMC8741415

In Vivo Hematopoietic Stem Cell Gene Therapy for SARS-CoV2 Infection Using a Decoy Receptor.

Autor: Wang, Hongjie, Li, Chang, Obadan, Adebimpe O., Frizzell, Hannah, Hsiang, Tien-Ying, Gil, Sucheol, Germond, Audrey, Fountain, Connie, Baldessari, Audrey, Roffler, Steve, Kiem, Hans-Peter, Fuller, Deborah H., Lieber, André

Publikováno v: Human Gene Therapy; Apr2022, Vol. 33 Issue 7-8, p389-403, 15p