Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Autor: Mike B. Barnkob, Yale S. Michaels, Violaine André, Philip S. Macklin, Uzi Gileadi, Salvatore Valvo, Margarida Rei, Corinna Kulicke, Ji-Li Chen, Vitul Jain, Victoria K. Woodcock, Huw Colin-York, Andreas V. Hadjinicolaou, Youxin Kong, Viveka Mayya, Julie M. Mazet, Gracie-Jennah Mead, Joshua A. Bull, Pramila Rijal, Christopher W. Pugh, Alain R. Townsend, Audrey Gérard, Lars R. Olsen, Marco Fritzsche, Tudor A. Fulga, Michael L. Dustin, E. Yvonne Jones, Vincenzo Cerundolo

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)

Externí odkaz: https://doaj.org/article/c91684507e624290b137868f21bb7e7e

Modes of Communication between T Cells and Relevance for Immune Responses

Autor: Lion F. K. Uhl, Audrey Gérard

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 8, p 2674 (2020)

T cells are essential mediators of the adaptive immune system, which constantly patrol the body in search for invading pathogens. During an infection, T cells that recognise the pathogen are recruited, expand and differentiate into subtypes tailored

Externí odkaz: https://doaj.org/article/c1134acb1cd04fa9a3a2a81a6d070501

Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues

Autor: Marina Botto, Emma E Dutton, Emily E. Halford, Remi Fiancette, David R. Withers, Dominika W Gajdasik, Andrew S. MacDonald, Timo Rückert, Audrey Gérard, Fabrina Gaspal, Timothy J. Vyse, Sarah L Bevington, Chiara Romagnani, Claire Willis

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Gajdasik, D W, Gaspal, F, Halford, E E, Fiancette, R, Dutton, E E, Willis, C, Rückert, T, Romagnani, C, Gerard, A, Bevington, S L, MacDonald, A S, Botto, M, Vyse, T & Withers, D R 2020, ' Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues ', Nature Communications, vol. 11, no. 1, pp. 3421 . https://doi.org/10.1038/s41467-020-17293-3
Nature Communications

The OX40-OX40L pathway provides crucial co-stimulatory signals for CD4 T cell responses, however the precise cellular interactions critical for OX40L provision in vivo and when these occur, remains unclear. Here, we demonstrate that provision of OX40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aabc153688599509231c77150fede52
http://link.springer.com/article/10.1038/s41467-020-17293-3

Spatiotemporal behavior of T cells in vaccination

Autor: Ana Laura, Chiodetti, Audrey, Gérard

Publikováno v: The International Journal of Biochemistry & Cell Biology. 147:106224

Vaccines are the most cost-effective resource to contain and eliminate infectious diseases. Despite decades of research in the field, several pathogens have eluded the effect of conventional vaccines mostly due their failure in inducing strong T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f0496b744a71e266dc181b8b1b8f7a
https://doi.org/10.1016/j.biocel.2022.106224

Interferon-γ couples CD8+ T cell avidity and differentiation during infection

Autor: Lion F. K. Uhl, Han Cai, Sophia L. Oram, Jagdish N. Mahale, Andrew J. MacLean, Julie M. Mazet, Theo Piccirilli, Alexander J. He, Doreen Lau, Tim Elliott, Audrey Gerard

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Effective responses to intracellular pathogens are characterized by T cell clones with a broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell clones are selected throughout the response to retain a bre

Externí odkaz: https://doaj.org/article/93ce11988e134251aa03f8a54f6cf7df