Výsledky vyhledávání - "Audrey Deligny"

NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length

Autor: Lena Kjellén, Audrey Deligny, Alison V. Nairn, Anders Lundequist, Tabea Dierker, Anders Dagälv, Catherine L.R. Merry, Inger Eriksson, Kelley W. Moremen

Publikováno v: Journal of Biological Chemistry. 291:18600-18607

Analysis of heparan sulfate synthesized by HEK 293 cells overexpressing murine NDST1 and/or NDST2 demonstrated that the amount of heparan sulfate was increased in NDST2- but not in NDST1-overexpressing cells. Altered transcript expression of genes en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7de433ce16d909cdc032d8560290131
https://doi.org/10.1074/jbc.m116.744433

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Cyclophilin B Attenuates the Expression of TNF-α in Lipopolysaccharide-Stimulated Macrophages through the Induction of B Cell Lymphoma-3

Autor: Pierre Martinez, Adeline Marcant, Mathieu Carpentier, Agnès Denys, Aurélie Melchior, Fabrice Allain, Audrey Deligny

Publikováno v: The Journal of Immunology. 189:2023-2032

Extracellular cyclophilin A (CyPA) and CyPB have been well described as chemotactic factors for various leukocyte subsets, suggesting their contribution to inflammatory responses. Unlike CyPA, CyPB accumulates in extracellular matrixes, from which it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d34d7d8ad336c5ed875ff0bbd42d66c
https://doi.org/10.4049/jimmunol.1102803

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Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking α-l-iduronidase

Autor: Audrey Deligny, Wei Wei, Rebecca J. Holley, Catherine L.R. Merry, Anders Dagälv, Brian W. Bigger, Milady R. Niñonuevo, Lena Kjellén, Julie A. Leary, H. Angharad Watson

Publikováno v: The Journal of biological chemistry. 286(43)

Mucopolysaccharide (MPS) diseases are characterized by accumulation of glycosaminoglycans (GAGs) due to deficiencies in lysosomal enzymes responsible for GAG breakdown. Using a murine model of MPSI Hurler (MPSIH), we have quantified the heparan sulfa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da8767a62298e140bc5a8a4412c0bb2
https://pubmed.ncbi.nlm.nih.gov/21873421

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Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases

Autor: Toin H. van Kuppevelt, Audrey Deligny, Adeline Marcant, Fabrice Allain, Aurélie Melchior, Agnès Denys, Joël Mazurier

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2010, 285 (3), pp.1701-15. ⟨10.1074/jbc.M109.018184⟩
Journal of Biological Chemistry, 285, 3, pp. 1701-15
Journal of Biological Chemistry, 2010, 285 (3), pp.1701-15. ⟨10.1074/jbc.M109.018184⟩
Journal of Biological Chemistry, 285, 1701-15

Contains fulltext : 89091.pdf (Publisher’s version ) (Open Access) Cyclophilin B (CyPB) induces migration and adhesion of T lymphocytes via a mechanism that requires interaction with 3-O-sulfated heparan sulfate (HS). HS biosynthesis is a complex p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77864e431b97c815fd04af9f417eebd
https://hal.archives-ouvertes.fr/hal-00469786

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Cyclophilin B induces integrin-mediated cell adhesion by a mechanism involving CD98-dependent activation of protein kinase C-delta and p44/42 mitogen-activated protein kinases

Autor: Agnès Denys, Joël Mazurier, Audrey Deligny, Fabrice Allain, Aurélie Melchior

Publikováno v: Experimental Cell Research
Experimental Cell Research, Elsevier, 2007, epub ahead of print. ⟨10.1016/j.yexcr.2007.11.007⟩
Experimental Cell Research, 2007, epub ahead of print. ⟨10.1016/j.yexcr.2007.11.007⟩

Initially identified as a cyclosporin-A binding protein, cyclophilin B (CyPB) is an inflammatory mediator that induces adhesion of T lymphocytes to fibronectin, by a mechanism dependent on CD147 and alpha 4 beta 1 integrins. Recent findings have sugg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79529d3889a49436b4e3f7de90b8ce3c
https://hal.archives-ouvertes.fr/hal-00195630

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The heparin/heparan sulfate sequence that interacts with cyclophilin B contains a 3-O-sulfated N-unsubstituted glucosamine residue

Autor: David G. Fernig, Agnès Denys, Fabrice Allain, Malcolm Lyon, Xavier Liénard, Aurélie Melchior, Audrey Deligny, Maryse Delehedde, Christophe Vanpouille, Joeöl Mazurier

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2007, 282 (33), pp.24416-29. ⟨10.1074/jbc.M701835200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, 282 (33), pp.24416-29. ⟨10.1074/jbc.M701835200⟩

Many of the biological functions of heparan sulfate (HS) proteoglycans can be attributed to specialized structures within HS moieties, which are thought to modulate binding and function of various effector proteins. Cyclophilin B (CyPB), which was in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b11220d291b3bec4f7e0ccdb3a942b
https://pubmed.ncbi.nlm.nih.gov/17588944

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