Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2

Autor: Raphaël Sierocki, Julien Barbier, Adam D. Linstedt, Ludger Johannes, Alison Forrester, Stefan J. Rathjen, Mathilde Munier, Sylvain Pichard, Daniel Gillet, Henri-François Renard, Christophe Lamaze, Damarys Loew, Maria Daniela Garcia-Castillo, Jennifer Martinez, Livia Tepshi, Jean-Christophe Cintrat, Collin Bachert, Audrey Couhert, Florent Dingli, Cesar Augusto Valades-Cruz

Publikováno v: Nature Chemical Biology
Nature Chemical Biology, 2020, 16 (3), pp.327-336. ⟨10.1038/s41589-020-0474-4⟩
Nature Chemical Biology, Nature Publishing Group, 2020, 16 (3), pp.327-336. ⟨10.1038/s41589-020-0474-4⟩

International audience; The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes and relocalization of the Golgi SNARE protein sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f0c3f57a783df4459e09cb7a9dde00
https://hal.science/hal-04003230

Synthesis of 2-arylfuro[3,2-b]pyridines: Effect of the C2-aryl group on melatoninergic activity

Autor: Agnes Chartier, Gérald Guillaumet, Audrey Couhert, Philippe Delagrange, Daniel-Henri Caignard, Franck Suzenet

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2016, 109, pp.268-275. ⟨10.1016/j.ejmech.2016.01.008⟩
European Journal of Medicinal Chemistry, 2016, 109, pp.268-275. ⟨10.1016/j.ejmech.2016.01.008⟩

We report herein an efficient synthesis of 2-substituted furo[3,2-b]pyridines and their biological evaluation as melatonin receptors ligands. The proposed eight-step sequence ending with a Suzuki coupling allowed a rapid access to various analogues.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb69c148a676e2297cc138b4bebc3e15
https://pubmed.ncbi.nlm.nih.gov/26785296