Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Audra M. Foshage"'
Autor:
Erin R. Aho, Jing Wang, Rocco D. Gogliotti, Gregory C. Howard, Jason Phan, Pankaj Acharya, Jonathan D. Macdonald, Ken Cheng, Shelly L. Lorey, Bin Lu, Sabine Wenzel, Audra M. Foshage, Joseph Alvarado, Feng Wang, J. Grace Shaw, Bin Zhao, April M. Weissmiller, Lance R. Thomas, Christopher R. Vakoc, Matthew D. Hall, Scott W. Hiebert, Qi Liu, Shaun R. Stauffer, Stephen W. Fesik, William P. Tansey
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 2916-2928.e13 (2019)
Summary: The chromatin-associated protein WDR5 is a promising target for pharmacological inhibition in cancer. Drug discovery efforts center on the blockade of the “WIN site” of WDR5, a well-defined pocket that is amenable to small molecule inhib
Externí odkaz:
https://doaj.org/article/624392b24e9c465daac627e90b1195e5
Autor:
Kristen D. Nordham, Michael T. O’Brien, Piyush Joshi, Vittorio Maglione, Audra M. Foshage, Rachana Nitin, Miles R. Bryan, Aaron B. Bowman, Daniel I.R. Rose, Alba Di Pardo, Michael Aschner, Michael A. Uhouse, Ziyan Zhang
Publikováno v:
Hum Mol Genet
The molecular etiology linking the pathogenic mutations in the Huntingtin (Htt) gene with Huntington’s disease (HD) is unknown. Prior work suggests a role for Htt in neuronal autophagic function and mutant HTT protein disrupts autophagic cargo load
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d6f3fe86524de9235aa52d0f452976
https://doi.org/10.1093/hmg/ddz209
https://doi.org/10.1093/hmg/ddz209
Autor:
Joel S. Arackal, Tayler D. Sheahan, Manish K. Madasu, Audra M Foshage, Sree Palanisamy, Loc V. Thang, Priyanka Chilukuri, Jordan G. McCall, Richard A. Houghten, Ream Al-Hasani, Jay P. McLaughlin
Noxious cold sensation is commonly associated with peripheral neuropathies, however, there has been limited progress in understanding the mechanism of cold pain. Transient receptor potential (TRP) A1 channels facilitate the perception of noxious cold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f97b3de5845aad6061b1c8ccc051243b
https://doi.org/10.1101/2020.10.04.325118
https://doi.org/10.1101/2020.10.04.325118
Autor:
Miles R. Bryan, Michael Aschner, Michael A. Uhouse, Michael T. O’Brien, Filipe Marques Gonçalves, Daniel I.R. Rose, Kristen D. Nordham, Rachana Nitin, Aaron B. Bowman, Piyush Joshi, Audra M. Foshage
Publikováno v:
Mol Neurobiol
Perturbations in insulin/IGF signaling and manganese (Mn(2+)) uptake and signaling have been separately reported in Huntington’s disease (HD) models. Insulin/IGF supplementation ameliorates HD phenotypes via upregulation of AKT, a known Mn(2+)-resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe5e312b86e57f887369d44158855a7
https://pubmed.ncbi.nlm.nih.gov/31797328
https://pubmed.ncbi.nlm.nih.gov/31797328
Autor:
April M. Weissmiller, Christine M. Eischen, Bethany A. Carboneau, Tessa M. Popay, Victoria H. Ng, Brian C. Grieb, Audra M. Foshage, William P. Tansey, Shelly L. Lorey, Lance R. Thomas, Susan J. Qualls
Publikováno v:
Oncogene
The MYC family of oncogenes encodes a set of three related transcription factors that are overexpressed in many human tumors and contribute to the cancer-related deaths of more than 70,000 Americans every year. MYC proteins drive tumorigenesis by int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8665292b4449e0b4d33846aeff7504
https://doi.org/10.1038/onc.2015.416
https://doi.org/10.1038/onc.2015.416
Publikováno v:
Cancer Research. 75:4012-4015
The MYC oncogenes encode a family of transcription factors that feature prominently in cancer. MYC proteins are overexpressed or deregulated in a majority of malignancies and drive tumorigenesis by inducing widespread transcriptional reprogramming th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8717af70cd4de3070393899e9a3458f4
https://doi.org/10.1158/0008-5472.can-15-1216
https://doi.org/10.1158/0008-5472.can-15-1216
Autor:
Bethany M. Alicie, Travis Clark, Qingguo Wang, Soumyadeep Dey, Gregory C. Howard, Qi Sun, Audra M. Foshage, Christine M. Eischen, Edward T. Olejniczak, Stephen W. Fesik, William P. Tansey, Zhongming Zhao, Lance R. Thomas, Jason Phan, Kevin C. Ess, Bryan Cawthon, Shelly L. Lorey, Brian C. Grieb
Publikováno v:
Molecular Cell. 58(3):440-452
MYC is an oncoprotein transcription factor that is overexpressed in the majority of malignancies. The oncogenic potential of MYC stems from its ability to bind regulatory sequences in thousands of target genes, which depends on interaction of MYC wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d97ccda2054aac62dec0cf584435058
Autor:
Bin Lu, J.G. Shaw, Hall, Bin Zhao, Jason Phan, Rocco D. Gogliotti, William P. Tansey, Shaun R. Stauffer, Christopher R. Vakoc, Feng Wang, Scott W. Hiebert, Jing Wang, Erin R. Aho, Kenneth Cheng, April M. Weissmiller, Stephen W. Fesik, Qi Liu, Lance R. Thomas, Joseph Alvarado, Pankaj Acharya, Shelly L. Lorey, Gregory C. Howard, Sabine Wenzel, Audra M. Foshage, Jonathan David Macdonald
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 2916-2928.e13 (2019)
Cell reports
Cell reports
SUMMARY The chromatin-associated protein WDR5 is a promising target for pharmacological inhibition in cancer. Drug discovery efforts center on the blockade of the “WIN site” of WDR5, a well-defined pocket that is amenable to small molecule inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58bc960c68462edc4688ffa6afd77af7
https://doi.org/10.1016/j.celrep.2019.02.047
https://doi.org/10.1016/j.celrep.2019.02.047
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 38(12)
Activation of kappa-opioid receptors (KORs) in monoamine circuits results in dysphoria-like behaviors and stress-induced reinstatement of drug seeking in both conditioned place preference (CPP) and self-administration models. Noradrenergic (NA) recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc3da871df6ab2fd6fc620e4abe9bc3
https://pubmed.ncbi.nlm.nih.gov/23787819
https://pubmed.ncbi.nlm.nih.gov/23787819
Autor:
Eli Q Harris, Cheryl L. Stucky, Victoria M Wang, Gina M. Story, Yingqi Weng, Patricia A Batista-Schepman, Marie E. Barabas, Michelle Wang, Audra M Foshage, Matthew J Schwab, Elena A. Kossyreva, Thomas B Dinsmore
Publikováno v:
Molecular Pain, Vol 8, Iss 1, p 75 (2012)
Molecular Pain
Molecular Pain
Background: The Transient Receptor Potential (TRP) ion channel TRPA1 is a key player in pain pathways. Irritant chemicals activate ion channel TRPA1 via covalent modification of N-terminal cysteines. We and others have shown that 15-Deoxy-Δ12, 14-pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0301f036740b5d06c5136b57396dd0