Complex effects on CaV2.1 channel gating caused by a CACNA1A variant associated with a severe neurodevelopmental disorder

Autor: Benjamin J. Grosso, Audra A. Kramer, Sidharth Tyagi, Daniel F. Bennett, Cynthia J. Tifft, Precilla D’Souza, Michael F. Wangler, Ellen F. Macnamara, Ulises Meza, Roger A. Bannister

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract P/Q-type Ca2+ currents mediated by CaV2.1 channels are essential for active neurotransmitter release at neuromuscular junctions and many central synapses. Mutations in CACNA1A, the gene encoding the principal CaV2.1 α1A subunit, cause a bro

Externí odkaz: https://doaj.org/article/dcb8f1d708834618b720d6b36eaa5a9b

Optogenetic Interrogation of Functional Synapse Formation by Corticospinal Tract Axons in the Injured Spinal Cord

Autor: Eric Balle, Murray Blackmore, Naveen Jayaprakash, Brian Hoeynck, Nicholas Krueger, Zimei Wang, Audra A. Kramer, Robert A. Wheeler, Daniel S. Wheeler

Publikováno v: The Journal of Neuroscience. 36:5877-5890

To restore function after injury to the CNS, axons must be stimulated to extend into denervated territory and, critically, must form functional synapses with appropriate targets. We showed previously that forced overexpression of the transcription fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3084baff87f0fda08d3f76c750b67497
https://doi.org/10.1523/jneurosci.4203-15.2016

Levels of 1.2 L-Type Channels Peak in the First Two Weeks in Rat Hippocampus Whereas 1.3 Channels Steadily Increase through Development

Autor: Nicholas E. Ingraham, Emily J. Sharpe, Audra A. Kramer, Michelle Mynlieff

Publikováno v: Journal of Signal Transduction. 2012:1-11

Influx of calcium through voltage-dependent channels regulates processes throughout the nervous system. Specifically, influx through L-type channels plays a variety of roles in early neuronal development and is commonly modulated by G-protein-coupled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edb3c460c0cc29296ad1e04cb98d5d9a
https://doi.org/10.1155/2012/597214

Increased prefrontal cortex neurogranin enhances plasticity and extinction learning

Autor: Geoffrey G. Murphy, Jamie N. Krueger, Kanwardeep Kaleka, Matthew A. Florence, Joshua C. Brown, Audra A. Kramer, Michelle Battle, Nashaat Z. Gerges, Ling Zhong, Amber Petersen, Matthew J. Muelbl, Christopher M. Olsen

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(19)

Increasing plasticity in neurons of the prefrontal cortex (PFC) has been proposed as a possible therapeutic tool to enhance extinction, a process that is impaired in post-traumatic stress disorder, schizophrenia, and addiction. To test this hypothesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8ca510642d36b3cf2344e0363d170e
https://pubmed.ncbi.nlm.nih.gov/25972176

Advances in Ca V 1.1 gating: New insights into permeation and voltage-sensing mechanisms.

Autor: Bibollet H; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA., Kramer A; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA., Bannister RA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA., Hernández-Ochoa EO; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.

Publikováno v: Channels (Austin, Tex.) [Channels (Austin)] 2023 Dec; Vol. 17 (1), pp. 2167569.