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A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells.

Autor: Kovtun Y; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Jones GE; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Adams S; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Harvey L; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Audette CA; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Wilhelm A; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Bai C; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Rui L; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Laleau R; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Liu F; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Ab O; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Setiady Y; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Yoder NC; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Goldmacher VS; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Chari RVJ; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Pinkas J; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA., Chittenden T; Science, Technology, and Translation, ImmunoGen, Inc, Waltham MA.

Publikováno v: Blood advances [Blood Adv] 2018 Apr 24; Vol. 2 (8), pp. 848-858.

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Akademický článek

A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity.

Autor: Miller ML; ImmunoGen, Inc., Waltham, Massachusetts., Fishkin NE; ImmunoGen, Inc., Waltham, Massachusetts., Li W; ImmunoGen, Inc., Waltham, Massachusetts., Whiteman KR; ImmunoGen, Inc., Waltham, Massachusetts., Kovtun Y; ImmunoGen, Inc., Waltham, Massachusetts., Reid EE; ImmunoGen, Inc., Waltham, Massachusetts., Archer KE; ImmunoGen, Inc., Waltham, Massachusetts., Maloney EK; ImmunoGen, Inc., Waltham, Massachusetts., Audette CA; ImmunoGen, Inc., Waltham, Massachusetts., Mayo MF; ImmunoGen, Inc., Waltham, Massachusetts., Wilhelm A; ImmunoGen, Inc., Waltham, Massachusetts., Modafferi HA; ImmunoGen, Inc., Waltham, Massachusetts., Singh R; ImmunoGen, Inc., Waltham, Massachusetts., Pinkas J; ImmunoGen, Inc., Waltham, Massachusetts., Goldmacher V; ImmunoGen, Inc., Waltham, Massachusetts., Lambert JM; ImmunoGen, Inc., Waltham, Massachusetts., Chari RV; ImmunoGen, Inc., Waltham, Massachusetts. ravi.chari@immunogen.com.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2016 Aug; Vol. 15 (8), pp. 1870-8. Date of Electronic Publication: 2016 May 23.

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Akademický článek

Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing.

Autor: Widdison WC; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Ponte JF; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Coccia JA; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Lanieri L; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Setiady Y; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Dong L; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Skaletskaya A; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Hong EE; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Wu R; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Qiu Q; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Singh R; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Salomon P; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Fishkin N; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Harris L; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Maloney EK; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Kovtun Y; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Veale K; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Wilhelm SD; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Audette CA; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Costoplus JA; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States., Chari RV; ImmunoGen Inc. , Waltham, Massachusetts 02451, United States.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2015 Nov 18; Vol. 26 (11), pp. 2261-78. Date of Electronic Publication: 2015 Sep 30.

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Akademický článek

High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.

Autor: Goldmacher VS; Department of Cell Biology, ImmunoGen, Inc., Waltham, Massachusetts, United States of America., Audette CA; Department of Cell Biology, ImmunoGen, Inc., Waltham, Massachusetts, United States of America., Guan Y; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America; Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, United States of America., Sidhom EH; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America; Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, United States of America., Shah JV; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America; Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, United States of America., Whiteman KR; Department of Cell Biology, ImmunoGen, Inc., Waltham, Massachusetts, United States of America., Kovtun YV; Department of Cell Biology, ImmunoGen, Inc., Waltham, Massachusetts, United States of America.

Publikováno v: PloS one [PLoS One] 2015 Feb 11; Vol. 10 (2), pp. e0117523. Date of Electronic Publication: 2015 Feb 11 (Print Publication: 2015).

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