Zobrazeno 1 - 10 of 34 pro vyhledávání: '"Aude Gleizes"'
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Akademický článek
Assessing the effect of genetic markers on drug immunogenicity from a mechanistic model-based approach
Autor: Julianne Duhazé, Miguel Caubet, Signe Hässler, Delphine Bachelet, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Aude Gleizes, Salima Hacein-Bey-Abina, Xavier Mariette, Marc Pallardy, Philippe Broët, on behalf of the ABIRISK Consortium
Publikováno v: BMC Medical Research Methodology, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background With the growth in use of biotherapic drugs in various medical fields, the occurrence of anti-drug antibodies represents nowadays a serious issue. This immune response against a drug can be due either to pre-existing antibodies or
Externí odkaz: https://doaj.org/article/e376e3073012448d8b8de8a68028e116
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3
Akademický článek
Validation Study of a New Random-Access Chemiluminescence Immunoassay Analyzer i-TRACK10® to Monitor Infliximab and Adalimumab Serum trough Levels and Anti-Drug Antibodies
Autor: Anne Emmanuelle Berger, Aude Gleizes, Louis Waeckel, Xavier Roblin, Roman Krzysiek, Salima Hacein-Bey-Abina, Alessandra Soriano, Stephane Paul
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 17, p 9561 (2022)
Background. Monitoring of biological TNF inhibitors is a very important tool to guide clinical decisions using specialized algorithms, especially in gastroenterology. A new chemiluminescent instrument (i-TRACK10® from Theradiag) could replace ELISA
Externí odkaz: https://doaj.org/article/88082a09d693401a8874c1210f106644
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4
Akademický článek
Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium.
Autor: Signe Hässler, Delphine Bachelet, Julianne Duhaze, Natacha Szely, Aude Gleizes, Salima Hacein-Bey Abina, Orhan Aktas, Michael Auer, Jerôme Avouac, Mary Birchler, Yoram Bouhnik, Olivier Brocq, Dorothea Buck-Martin, Guillaume Cadiot, Franck Carbonnel, Yehuda Chowers, Manuel Comabella, Tobias Derfuss, Niek De Vries, Naoimh Donnellan, Abiba Doukani, Michael Guger, Hans-Peter Hartung, Eva Kubala Havrdova, Bernhard Hemmer, Tom Huizinga, Kathleen Ingenhoven, Poul Erik Hyldgaard-Jensen, Elizabeth C Jury, Michael Khalil, Bernd Kieseier, Anna Laurén, Raija Lindberg, Amy Loercher, Enrico Maggi, Jessica Manson, Claudia Mauri, Badreddine Mohand Oumoussa, Xavier Montalban, Maria Nachury, Petra Nytrova, Christophe Richez, Malin Ryner, Finn Sellebjerg, Claudia Sievers, Dan Sikkema, Martin Soubrier, Sophie Tourdot, Caroline Trang, Alessandra Vultaggio, Clemens Warnke, Sebastian Spindeldreher, Pierre Dönnes, Timothy P Hickling, Agnès Hincelin Mery, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Xavier Mariette, Marc Pallardy, Philippe Broët, ABIRISK consortium
Publikováno v: PLoS Medicine, Vol 17, Iss 10, p e1003348 (2020)
BackgroundBiopharmaceutical products (BPs) are widely used to treat autoimmune diseases, but immunogenicity limits their efficacy for an important proportion of patients. Our knowledge of patient-related factors influencing the occurrence of antidrug
Externí odkaz: https://doaj.org/article/4a837373673e4bce970064eeadc29077
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5
Akademický článek
A Machine Learning Approach for High-Dimensional Time-to-Event Prediction With Application to Immunogenicity of Biotherapies in the ABIRISK Cohort
Autor: Julianne Duhazé, Signe Hässler, Delphine Bachelet, Aude Gleizes, Salima Hacein-Bey-Abina, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Xavier Mariette, Marc Pallardy, Philippe Broët
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Predicting immunogenicity for biotherapies using patient and drug-related factors represents nowadays a challenging issue. With the growing ability to collect massive amount of data, machine learning algorithms can provide efficient predictive tools.
Externí odkaz: https://doaj.org/article/46f1c812769c448fa17c62ce8e70ea24
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6
Akademický článek
Low Percentage of Signal Regulatory Protein α/β+ Memory B Cells in Blood Predicts Development of Anti-drug Antibodies (ADA) in Adalimumab-Treated Rheumatoid Arthritis Patients
Autor: Laura Magill, Marsilio Adriani, Véronique Berthou, Keguan Chen, Aude Gleizes, Salima Hacein-Bey-Abina, Agnes Hincelin-Mery, Xavier Mariette, Marc Pallardy, Sebastian Spindeldreher, Natacha Szely, David A. Isenberg, Jessica J. Manson, Elizabeth C. Jury, Claudia Mauri
Publikováno v: Frontiers in Immunology, Vol 9 (2018)
An important goal for personalized treatment is predicting response to a particular therapeutic. A drawback of biological treatment is immunogenicity and the development of antibodies directed against the drug [anti-drug antibodies (ADA)], which are
Externí odkaz: https://doaj.org/article/9291a5574cec46f0b474333af96ce3b4
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8
Articular manifestations in patients with inflammatory bowel diseases treated with anti-TNF
Autor: Laurie Cachen, Gaetane Nocturne, Michael Collins, Antoine Meyer, Aude Gleizes, Salima Hacein-Bey-Abina, Franck Carbonnel, Xavier Mariette, Raphaele Seror
Publikováno v: RMD Open
RMD Open, Vol 8, Iss 1 (2022)
ObjectiveTo describe and identify factors associated with articular manifestations occurring in patients treated with anti-tumour necrosis factor (TNF) for inflammatory bowel diseases (IBDs).MethodsRetrospective monocentric study, including all patie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925205605a7c87bd3b31fd465d9c4aef
http://europepmc.org/articles/PMC8804691
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9
La diminution de l’expression de CD39 sur les cellules B prédit l’apparition d’anticorps anti-médicament chez les patients atteints de PR traités par rituximab
Autor: Bineta Ly, Philippe Broët, Marc Pallardy, Aude Gleizes, S. Bitoun, Signe Hässler, Audrey Paoletti, S Hacein Bey, Xavier Mariette
Publikováno v: Revue du Rhumatisme. 88:A134-A135
Introduction Les anticorps anti-medicament (ADAb) sont bien decrits et diminuent la reponse au traitement par anticorps monoclonaux anti-TNF (TNFi). Le rituximab (RTX) a un potentiel immunogene important car c’est anticorps chimerique. Les etudes r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8308435470bc82f8dfc4ede08839313b
https://doi.org/10.1016/j.rhum.2021.10.211
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10
Assessing the effect of genetic markers on drug immunogenicity from a mechanistic model-based approach
Autor: Marc Pallardy, Aude Gleizes, Xavier Mariette, Julianne Duhazé, Florian Deisenhammer, Salima Hacein-Bey-Abina, Anna Fogdell-Hahn, Delphine Bachelet, Philippe Broët, Signe Hässler, Matthieu Allez, Miguel Caubet
Publikováno v: BMC Medical Research Methodology
BMC Medical Research Methodology, BioMed Central, 2020, 20 (1), pp.69. ⟨10.1186/s12874-020-00941-z⟩
BMC Medical Research Methodology, 2020, 20 (1), pp.69. ⟨10.1186/s12874-020-00941-z⟩
BMC Medical Research Methodology, Vol 20, Iss 1, Pp 1-10 (2020)
Background With the growth in use of biotherapic drugs in various medical fields, the occurrence of anti-drug antibodies represents nowadays a serious issue. This immune response against a drug can be due either to pre-existing antibodies or to the n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fb6f0356d02fa84348173edc73730e
https://hal.sorbonne-universite.fr/hal-02538677
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