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Akademický článek

The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages

Autor: Karim Chebli, Laura Papon, Conception Paul, Aude Garcel, Noëlie Campos, Didier Scherrer, Hartmut J. Ehrlich, Michael Hahne, Jamal Tazi

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract The progression of human immunodeficiency virus (HIV) is associated with mucosal damage in the gastrointestinal (GI) tract. This damage enables bacterial translocation from the gut and leads to subsequent inflammation. Dextran sulfate sodium

Externí odkaz: https://doaj.org/article/908d748ddfcb49b68fb516df8640bcdd

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ABX464 (obefazimod) up-regulates miR-124 to reduce pro-inflammatory markers in inflammatory bowel diseases

Autor: Cécile Apolit, Noëlie Campos, Audrey Vautrin, Christina Begon-Pescia, Laure Lapasset, Didier Scherrer, Paul Gineste, Hartmut Ehrlich, Aude Garcel, Julien Santo, Jamal Tazi

Publikováno v: Clinical and translational gastroenterology.

Advanced therapies have transformed the treatment of inflammatory bowel disease; however, many patients fail to respond, highlighting the need for therapies tailored to the underlying cell and molecular disease drivers. The first-in-class oral molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17eab20fe2efb7d604f0096b9fdcf4e
https://pubmed.ncbi.nlm.nih.gov/36573890

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Targeting the Long Non-Coding RNA LINC00599-205 splicing by novel candidate drug ABX464 to produce the anti-inflammatory microRNA miR-124

Autor: Aude Garcel, Jamal Tazi, Audrey Vautrin, Laurent Manchon, Noëlie Campos

Publikováno v: American Journal of Biomedical Science & Research
American Journal of Biomedical Science & Research, BiomedGrid, LLC, 2020, 7 (2), pp.196-203. ⟨10.34297/AJBSR.2020.07.001140⟩

Many nascent long non-coding RNAs have received considerable attention in recent years because of their major regulatory roles in gene expression and signaling pathways at various levels. Indeed long non-coding RNAs undergo the same maturation steps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2a12f898a45a382b6fb827b027942c
https://hal.archives-ouvertes.fr/hal-02450788

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The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages

Autor: Didier Scherrer, Conception Paul, Karim Chebli, Aude Garcel, Hartmut J. Ehrlich, Jamal Tazi, Laura Papon, Noëlie Campos, Michael Hahne

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-04071-3⟩
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-04071-3⟩

The progression of human immunodeficiency virus (HIV) is associated with mucosal damage in the gastrointestinal (GI) tract. This damage enables bacterial translocation from the gut and leads to subsequent inflammation. Dextran sulfate sodium (DSS-exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a335a43f41135e907b4fc87116d731ef
https://doaj.org/article/908d748ddfcb49b68fb516df8640bcdd

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Targeting Long Non-Coding RNA splicing by novel candidate drug

Autor: Jamal Tazi, Laurent Manchon, Audrey Vautrin, Aude Garcel, Noëlie Campos

Publikováno v: BIBM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24ff438792a1ab1c152def3c656c8ab2
https://doi.org/10.1109/bibm47256.2019.8982977

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Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing

Autor: Aude Garcel, Didier Scherrer, Jamal Tazi, Noëlie Campos, J Hartmut Ehrlich, Roman Bruno, Laure Lapasset, Abdelhamid Mahdi Laaref, Emeric Dubois, Marie Gislard, Laurent Manchon, Audrey Vautrin

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-018-37813-y⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-018-37813-y⟩

ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad155f1b425ccccee051ba918e315884
http://europepmc.org/articles/PMC6349857

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Vaccinia virus-induced smallpox postvaccinal encephalitis in case of blood–brain barrier damage

Autor: Marie-Pierre Dehouck, William Fauquette, Anne-Laure Favier, Aude Garcel, Jean-Marc Crance

Publikováno v: Vaccine. 30:1397-1405

Smallpox vaccination is the only currently effective mean to combat the threat of variola virus used as a bioterrorism agent, although it is responsible for a rare but serious complication, the postvaccinal encephalitis (PVE). Development of safer va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59252f68ddddcdff5bdeeb9fc239ff1b
https://doi.org/10.1016/j.vaccine.2011.08.116

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Genomic sequence of a clonal isolate of the vaccinia virus Lister strain employed for smallpox vaccination in France and its comparison to other orthopoxviruses

Autor: Daniel Garin, Aude Garcel, Robert Drillien, Jean-Marc Crance, Anne-Laure Favier

Publikováno v: Journal of General Virology
Journal of General Virology, Microbiology Society, 2007, 88 (Pt 7), pp.1906-16. ⟨10.1099/vir.0.82708-0⟩

Since 1980 there has been global eradication of smallpox due to the success of the vaccination programme using vaccinia virus (VACV). During the eradication period, distinct VACV strains circulated, the Lister strain being the most commonly employed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccff295f0a5a080bc74569e3fe8d4fd
https://doi.org/10.1099/vir.0.82708-0

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Long lasting control of viral rebound with a new drug ABX464 targeting Rev – mediated viral RNA biogenesis

Autor: Mark A. Wainberg, Julian P. Venables, Romain Najman, Didier Scherrer, Bernard Pau, Florence Mahuteau-Betzer, Renier Myburgh, Jamal Tazi, Laure Lapasset, Aude Garcel, Roberto F. Speck, Edouard Bertrand, Katjana Tantale, Erika Schläpfer Nadal, Audrey Vautrin, Martial Séveno, Pauline Fornarelli, Eugenia Basyuk, Noëlie Campos

Publikováno v: Retrovirology
Retrovirology, BioMed Central, 2015, 12, pp.30. ⟨10.1186/s12977-015-0159-3⟩

International audience; Background: Current therapies have succeeded in controlling AIDS pandemic. However, there is a continuing need for new drugs, in particular those acting through new and as yet unexplored mechanisms of action to achieve HIV inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c572c25d5383dac185375e39feea564
https://doi.org/10.1186/s12977-015-0159-3

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Phenotypic and genetic diversity of the traditional Lister smallpox vaccine

Autor: Daniel Garin, Aude Garcel, Robert Drillien, Julien Perino, Jean-Marc Crance, Anne-Laure Favier

Publikováno v: Vaccine
Vaccine, Elsevier, 2009, 27 (5), pp.708-17. ⟨10.1016/j.vaccine.2008.11.063⟩
Vaccine, 2009, 27 (5), pp.708-17. ⟨10.1016/j.vaccine.2008.11.063⟩

International audience; As an initial step in the development of a second-generation smallpox vaccine derived from the Lister strain, to be prepared for a variola virus threat, diversity of the traditional vaccine was examined by characterizing a ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679fbcfb08cde057851aafe7bca6a180
https://www.hal.inserm.fr/inserm-00357413

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