Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Aude Echalier"'
Autor:
Melissa Birol, Radoslav Ivanov Enchev, André Padilla, Florian Stengel, Ruedi Aebersold, Stéphane Betzi, Yinshan Yang, François Hoh, Matthias Peter, Christian Dumas, Aude Echalier
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105688 (2014)
The Cop9 signalosome complex (CSN) regulates the functional cycle of the major E3 ubiquitin ligase family, the cullin RING E3 ubiquitin ligases (CRLs). Activated CRLs are covalently modified by the ubiquitin-like protein Nedd8 (neural precursor cell
Externí odkaz:
https://doaj.org/article/dd21eb58c1874400958090539b7208ee
Autor:
Laurent Meijer, Benoît Joseph, Jane Endicott, Philippe Bernard, Aude Echalier, Moustapha Hassan, Guy Fournet, Florence Popowycz, Yoan Ferandin, Hatem Sallam, Karima Bettayeb
Supplementary Material from N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4ccac8540753c0caa17366e7bf88b9
https://doi.org/10.1158/1535-7163.22483583
https://doi.org/10.1158/1535-7163.22483583
Autor:
Laurent Meijer, Benoît Joseph, Jane Endicott, Philippe Bernard, Aude Echalier, Moustapha Hassan, Guy Fournet, Florence Popowycz, Yoan Ferandin, Hatem Sallam, Karima Bettayeb
Cyclin-dependent kinases (CDKs) and their regulators show frequent abnormalities in tumors. Ten low molecular weight pharmacologic inhibitors of CDKs are currently in clinical trials against various cancers, including the 2,6,9-trisubstituted purine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2214cb87994a773c141e1df4350fcdc4
https://doi.org/10.1158/1535-7163.c.6531170.v1
https://doi.org/10.1158/1535-7163.c.6531170.v1
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Protein kinases represent promising anticancer drug targets. We describe here the meriolins, a new family of inhibitors of cyclin-dependent kinases (CDK). Meriolins represent a chemical structural hybrid between meridianins and variolins, two familie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862a2f4d144630c783bf14488d81f62d
https://doi.org/10.1158/0008-5472.c.6495774.v1
https://doi.org/10.1158/0008-5472.c.6495774.v1
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Supplementary Figure 4 from Meriolins, a New Class of Cell Death–Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3970f1381a1112fc3eac3f8d94c493
https://doi.org/10.1158/0008-5472.22368006
https://doi.org/10.1158/0008-5472.22368006
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Methods and Materials, Figure 4 Legend from Meriolins, a New Class of Cell Death–Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518409c14552a25e83b2c37283b71aa5
https://doi.org/10.1158/0008-5472.22368009
https://doi.org/10.1158/0008-5472.22368009
Autor:
Bohdan Waszkowycz, Habiba Begum, Chitra Seewooruthun, Aude Echalier, Amanda J. Watson, Stuart Donald Jones, Richard Bayliss, Mark W. Richards, Rebecca Newton, Li-Ying Lin, Daniel Burschowsky, Allan M. Jordan, Donald J. Ogilvie, Niall M. Hamilton, Samantha Hitchin, Eleanor French, Ian D. Waddell
Publikováno v:
ACS Med Chem Lett
[Image: see text] A combination of focused library and virtual screening, hit expansion, and rational design has resulted in the development of a series of inhibitors of RET(V804M) kinase, the anticipated drug-resistant mutant of RET kinase. These ag
Autor:
Arno F. Alpi, Aude Echalier
Publikováno v:
Cell Death & Disease
Cell Death and Disease
Cell Death and Disease
Autor:
Michaela Hylsová, Jindřich Fanfrlík, Kamil Paruch, Martin Lepšík, Pathik S. Brahmkshatriya, Aude Echalier, Vladimír Kryštof, Lenka Musilová, Benoit Carbain, Pavel Hobza, Radek Jorda, Cemal Köprülüoğlu, Susanta Haldar, Haresh Ajani
We present comprehensive testing of solvent representation in quantum mechanics (QM)-based scoring of protein-ligand affinities. To this aim, we prepared 21 new inhibitors of cyclin-dependent kinase 2 (CDK2) with the pyrazolo[1,5-a]pyrimidine core, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff55b4896483e77ca94a2153e7ccba7
https://ora.ox.ac.uk/objects/uuid:43f44ab7-8d22-446e-b571-e7a93d3341d3
https://ora.ox.ac.uk/objects/uuid:43f44ab7-8d22-446e-b571-e7a93d3341d3
Publikováno v:
Proceedings of the National Academy of Sciences. 106:4171-4176
Cyclin-dependent kinase 4 (CDK4)/cyclin D complexes are expressed early in the G 1 phase of the cell cycle and stimulate the expression of genes required for G 1 progression by phosphorylation of the product of the retinoblastoma gene, pRb. To elabor